Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MQPPYIQERLKSLNDVESQLCSMLQEASQVTFIFGELKRGNESVKPQFENHVKQFYELLDKSTTQLRKEIQLLDENVGTRLLPINVNKKALGQDTEKMEEQLDLLSVILDPSKSK |
Length | 115 |
Position | Head |
Organism | Saccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889) (Yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Saccharomyces. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.609 |
Instability index | 44.79 |
Isoelectric point | 5.22 |
Molecular weight | 13264.03 |
Publications | PubMed=12775844 PubMed=22384314 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29872 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) MQPPYIQERLK 2) SVKPQFENHVKQFYELLDKSTTQLRKEIQLLDENVGTRLLPINVNKKALGQDTEKMEEQLDLLSVILDPSK 3) VTFIFGELKRG | 1 43 30 | 11 113 40 |
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