Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKLIDERFERLEKALSGLIDSVTKYHPSMNLAEELMAADAELTKGLEQVQTHQNNHLRILELRQASTSLDTQIRDTLTSLSNTRRDIVNTHTTKFPSSPNYPIVYEELLSYARRISKTTMPPAATINASFPPSGLQSPTVGESQSQAVTPAATTPAAGATPATAATPATSTPLPTQSPAAINGVGGTHGVSLQHSSQHPHQGSSSGPSLLTSLPEPMAQYLNPLSGQVFFPWPQEDKIRSGSLASNQILVEKGIDPRGFDPVAEEERKRKEEADRKEREEREAREQEERDRIMREERERLRQERERQREKEQNEWRRASVIAGAADAPGGAAPKGPEKKQFQFTNLDDLDDDDDDD |
Length | 357 |
Position | Middle |
Organism | Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.881 |
Instability index | 52.20 |
Isoelectric point | 5.19 |
Molecular weight | 39507.15 |
Publications | PubMed=22761991 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29867 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 76.79| 23| 27| 266| 292| 1 --------------------------------------------------------------------------- 266- 292 (34.37/25.50) EERKRKeeadRKEREEREAREQEERDR 296- 318 (42.42/22.56) EERERL....RQERERQREKEQNEWRR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 106.83| 23| 26| 117| 139| 2 --------------------------------------------------------------------------- 82- 103 (38.56/18.13) SNTRRD....IVN...THTTKFP....SSP.NYP 117- 139 (43.15/21.02) SKTTMP....PAA...TINASFP....PSGLQSP 146- 179 (25.13/ 9.64) SQAVTPaattPAAgatPATAATPatstPLPTQSP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GAAPKGPEKKQFQFTNLDDLDDDDDDD 2) NEWRRASVIAGAADAP 3) PIVYEELL | 331 314 103 | 357 329 110 |
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