<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29865

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTVDSETNVLLVSNIASVAYRFYEPSADSKQTFFSNALGIETSLREQGRIVSFDATRRGLWYFHIRRSVGAESQGPAELGATAVVNDHLLMSTKHGSMEPSQWHKSLAPEPPTHRPNQTSSGHAAQLQLTGSQQDQEATAITEETELRQSNGFTPRVLYESFIGALLLTICSSFCSKSDAVPLNFRTVLLPALKASESATDRWIGEQAQVLGTLKCYMISTGSLILSFSVTVCPWLASLEDILSSNSNPIGNNILAAPFGVMTNEEQSPSSHSTGAPLAHTPTIQTLAQRSPSNANSSLWKQACLAIFQLRGVPGAALRECSWVNLLVSKPKLQDTKPENGRAAHSTISIPWPGSLCFRKKAVELSATNRISDTIVVGHDETHDPLGDARGWLSSANEREERISKRHAERSAAGAKENPAVDTRLGKINAPSPVTMRRPSTTGGNAVYPTPPDAIQNLNGVTPSMDGNLSSPGHPLSVVADVDIDCEPPGEENSVHQNDDEMTEAADGKPLRSDNNLLSEAENMFEDMGGDMFGDNDITEADFSFFDEQPDEMGMDMSFDSIKGSRVPSALPINAEEPVASASINAPPSAESAVFAKPELKHARSSQPEDAPQRGRDHPAKSAKRGSSPFDPDSVFKRLRAAASQRTPRGAYGVGLNRGIKVFEKVDFDSKMPMLNKKYEHGGLFDFVPNATDTDKLEPGTLPKTDYLRRHGKTRAKQQADSRRPSIVKSTTDPDTQLLDHRLLNLDGDISDGDDSSSDSDVASNLSVKEPVSPVKSTVKQSILGDDDAASYVTTGRDQDLAEEPDEQLALELPRLSLLDGPDTPLFRYFTDPEPLSLDISLSDEDMIQVAQLVAEQAAAGSLSIFSGHSDNALSTATEEDARIEQLTSTRCALQALRDAASSFLGTISPVGLKTLLEVQDGSLTGQGNRVQPRQVPSKDPNSEPIKPSNLYQIPCPHLEVRRADVRMSLLPTAVTFWENLGLAPSSGSKDIRAVCVCPKWTGMIDNAQVLLGRLKSTYETLKLGTFENMPLSAGLEDGVLLYGVDRISTAPDATMMGHGSALLESMETLSGAMSDLEVVDTNVVVYFMYSTSNPGTIVEACMAFQRFFESYRRTLVAKRESVKNEIVLQLVSADAISSSTSMVITPSSDLVKLCMETYDRCTLFGGNMPAPAIRLEQPLPRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVTAAWTDDRGNEQATAAYCLGHKGEPETRTMNDVAHEIWQTTVELISTWKVHYRIIMTKCGPADEGEIDFWVDLARTEMHASVTMIVMTVETNPSLQLVPAPIKMSLQPLSIYTTPVSTPQANIVSPEASAAPATPARDTTGAVATPGGESNGDADVDSVLADVMDQTWGAIVNHRLNNSVGTTSIQPALISGYLIKRTGPKAEDVPSIMEVNLVYTEASARTYEPLLREMLSYFRGLGTLARARGVVDRVTDDTWLLTGYPRSEAPNPYTPKAITAHLQRMAKSDKANFAQRGPAPQEMPAEAIPASDSREPHAGVGMPTVDDPFNFPTDEALPAYSAHPTDAAVPPVFADGAGPSSATAAALPPPPPGTSQVRPSLKPIAIPQVVPDASSPFVAAYPPCLLARGITEQSWISFLHTVSAFLTAKVGDRAVSHAGDMAKHFAQDSTNFGKSIASHSKTLGKDIAKHAKRGNIFGLAATLIHGAVSLPVMTALGAVDTATRLPGAAVGAITKKPKTPAERVNAYNVVANKKWLHQRGLHIQLVDTPGLAHVLQLPTAQLLAVARSGKEGSASGMLQALDLHIERLKVPAETSLGLSDKSLWLVLVEFDPEELQEPEDQSDGKVTGKK
Length1843
PositionKinase
OrganismBeauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.06
Grand average of hydropathy-0.300
Instability index45.76
Isoelectric point5.23
Molecular weight198344.93
Publications
PubMed=22761991

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29865
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     450.55|     115|     155|    1460|    1578|       1
---------------------------------------------------------------------------
 1329- 1421 (96.77/56.64)	..........................YTTPVSTP..QANIV...SPEASAAPATPARDTTGAVATPGGESN......GDADVDSVLADVMDQTWGAI..VNHRLNnsvgtTSIQPALISGylikrTGPKAED..
 1460- 1578 (192.12/133.34)	ARGvvdrVTDDTWLLTGYPRSEAPNPYTPKAITAHLQRMAK...SDKANFAQRGPAPQEMPAEAIPASDSREPHAGVGMPTVDDPFNFPTDEALPAY..SAHPTD.....AAVPPVFADG.....AGPSSATAA
 1620- 1739 (161.66/103.23)	ARG....ITEQSWISFLHTVSAFLTAKVGDRAVSHAGDMAKhfaQDSTNFGKSIASHSKTLGKDIAKHAKRGNIFGLAATLIHGAVSLPVMTALGAVdtATRLPG.....AAVGAITKKP.....KTPAERVNA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.05|      57|     118|     235|     296|       2
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  235-  296 (93.35/55.74)	PWLASL....EDILSSNSNPIGNNILaapfgVMTNEEQSPSSHSTG....APLAHTPTIQTLAQRSPSNA
  352-  416 (86.71/42.66)	PWPGSLcfrkKAVELSATNRISDTIV.....VGHDETHDPLGDARGwlssANEREERISKRHAERSAAGA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.69|      43|     155|     418|     479|       3
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  425-  472 (68.18/44.21)	RLGKINAPSPVTMRRPSTTGGNavypTPPDAiQNLNGVTPSMDGNLSS
  711-  753 (73.50/27.82)	RHGKTRAKQQADSRRPSIVKST....TDPDT.QLLDHRLLNLDGDISD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     327.57|     114|     143|    1039|    1181|       4
---------------------------------------------------------------------------
 1046- 1181 (171.83/173.40)	VD.RISTAPDATMMGHGS....ALLESMET..LSGAMSDLEVVDTNVVVYFMYSTSNPGTIVEACMAfqrfFESYRRTL.VAKRESVKNEIVL.QLVSAD..AI............SSSTSMVIT....PSSDLVklcmetydrctlfggnmPAPaIRLE.QPL
 1185- 1326 (155.74/98.92)	IDfKLSPAPSSSLARENScihiAYARSIDGrwVTAAWTDDRGNEQATAAYCLGHKGEPETRTMNDVA....HEIWQTTVeLISTWKVHYRIIMtKCGPADegEIdfwvdlartemhASVTMIVMTvetnPSLQLV.................PAP.IKMSlQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.02|      86|     118|     834|     925|       5
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  834-  925 (125.41/92.99)	PEPLSLDISLSDEDMIQVAQLVAEQAAA...............GsLSIFSGHSD.NALSTATEEDARIEqltSTRCALQALRDAASSF.LGTISPVGLKTLLEvqDGSL
  940- 1042 (133.61/82.04)	KDPNSEPIKPSNLYQIPCPHLEVRRADVrmsllptavtfwenlG.LAPSSGSKDiRAVCVCPKWTGMID...NAQVLLGRLKSTYETLkLGTFENMPLSAGLE..DGVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.27|      60|     137|     490|     552|       7
---------------------------------------------------------------------------
  490-  552 (101.36/76.79)	PGEENSVHQnddEMTEAADGKPLRSDNNL.LSEAENMFE..DMGGDMFGDNDITEAD..FSFFDEQPD
  630-  694 (92.91/61.92)	PFDPDSVFK...RLRAAASQRTPRGAYGVgLNRGIKVFEkvDFDSKMPMLNKKYEHGglFDFVPNATD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.12|      16|      16|     761|     776|       8
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  761-  776 (27.40/14.39)	SDV.ASNLSVKEPVSPV
  778-  794 (20.72/ 9.11)	STVkQSILGDDDAASYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.42|      17|      17|    1580|    1596|      12
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 1580- 1596 (32.57/16.41)	LPP.PPPGTSQVRPSLKP
 1599- 1616 (26.85/12.02)	IPQvVPDASSPFVAAYPP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29865 with Med13 domain of Kingdom Fungi
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