<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29860

Description Transcription mediator subunit Med12
SequenceMSSRNSMGVPQRAQQRALTGSALHAHQRSISSSHIQPHSPVRKDAFADHNQPTDPSDVATASSQATTASRHGATPRRAAGSKLRIELSNDDNVTPGPATDSPQATPSITSHSAAPDSSTDVSGHGSPALSRASHADSAIPRMPMPQRRGPLQRFVASSKTPAPPTAPLKRDSKPKQYSIEVPLDAPRFLSTNKQDAVHRDPFNKGLFSGNADFFPWTGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVTGALVLGNELKWIRDWTIFIEQFVDAVVSSVGEPDWKQRVTYSIRLATVLYSEHLLDRDHYLDWIVSGLENSSQAKLPMWILIAQICWTDILRSRKSGRRLVFALLNHLNTIYNDLDRDILMPLSNQLASLLKTLVVNNPESFIQPLQWLKYRESLSAFLPPDASILQQAYRSINQRNSELLVSSTASPPIGGKEHLVKLLDATLHGKVDRDLSTKCWSISEDKTQVLKTVIEWVTSFHRPGLEKIYTATNLLRSWGSFRINTTGAILDALDSIEPDDTVRKQAVYRLVTELARTGHFSISQYIQWLIARGNCHSAADVEDTGPCASRLLVELPVHCIPEDRKLDRANLLRRAANYDVADEARDIEIAIKCVSQTLGLPGYNIKHDDPALPSKPLPLRKLVSRINSSSFALKSALGTHIRDAFQRLLPPRLDADVSLNVFTSTRTILETTRDFSMLGEVIRSCSKISNIEVLAACVDTINVNLQILLAVGIADDLFTLFVERLKAASREHGLVARPLLAALSSLAQRMPNQGEMAKNLQQELTQTDRSNPIDACSPVSDNMVSQSTSPEGEVSEQIDRLLATGNSVDHPTMNRLFRHIVPRLEAGWNKLDASRRVYASLLARLRIFDTPHFDKLMSDWVSHIRSLKERPALLELLPLLVSLGCLTMATVLHTANAAPVAANVNAIEFGPPRGSAIYLEELLQLILRKLPQKSPLTADESYRFVVYQQSAKIEHSKALLLLIRNAVQEYSILRCRSSTTAPPLDDRSSQDDVLEALRVLVVTEPTAAAEALSMKDLAPEASALIRAIAAKLLAPGDENTSSSFDKILGLANELTMPFCQLSLSMELSLPQDSRNGNEADSQFDVFARAMDSAIEARNIMWTSMLPCLSDDITQHLRSQAHGRFLDMIPSSKAPNLTELATSEDRIQLAKNLLGVIEAIISGQPPSKSAQLTSMLVDKLTDLWEIISSHETSAARDAVRKHWLPFLLRFITLHSIYSSSSADVSTPTAASASGASSTVVNKNVNNVGAPAAATTATNSITNTNNEARARIVFVLCGILFALEAQQTLPPDGKLAQQVFDIALLLVDALPDDLRLHCARGVLANPSAVPSGPMASTATSSRGGTSDSRIYYLFSAPRPTAADNLMLAHRDKSAIPLSAAARGLGAMYGIGPTLQERYSHFTFRRWEALSEPTPNVGENDTSLSLGLFEAIKIQ
Length1573
PositionKinase
OrganismBeauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.06
Grand average of hydropathy-0.220
Instability index45.43
Isoelectric point8.72
Molecular weight172797.76
Publications
PubMed=22761991

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29860
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.28|      46|      94|     461|     509|       1
---------------------------------------------------------------------------
  461-  509 (69.54/66.39)	GRRLVFALLNhlNTIYNDLDRDI...LMPLSNQLASLLKTlVVNNPESFIQP
  556-  604 (76.74/59.65)	GKEHLVKLLD..ATLHGKVDRDLstkCWSISEDKTQVLKT.VIEWVTSFHRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.35|      24|     152|     653|     698|       2
---------------------------------------------------------------------------
  663-  693 (34.06/68.77)	ISQYIQWLIARGNchsAADvedtGPCASRLL
  935-  958 (43.29/17.31)	VSEQIDRLLATGN...SVD....HPTMNRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.66|      32|     548|     396|     428|       7
---------------------------------------------------------------------------
  396-  428 (55.19/32.83)	EPDWkQRVTYSIRL.ATVLYSEHLLDRDHY....LDWI
  966- 1002 (47.47/24.04)	EAGW.NKLDASRRVyASLLARLRIFDTPHFdklmSDWV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.70|      21|    1088|     230|     250|       8
---------------------------------------------------------------------------
  230-  250 (38.79/27.32)	IQKGT..WDRGSQNETSSARLAV
 1317- 1339 (32.91/21.89)	VDKLTdlWEIISSHETSAARDAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.46|      37|     124|     127|     164|       9
---------------------------------------------------------------------------
  127-  164 (64.47/43.80)	PALSRAS..HADSAIPRMPMPQRRGPLQRFVASSKTPaPP
  252-  290 (61.99/37.61)	PSLKQKTglNALSTIFMGVLNQRRNRGQITAPSTFKP.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.84|      33|     502|     615|     654|      11
---------------------------------------------------------------------------
  615-  654 (43.05/49.20)	LLRSWGSfrinTTGAILDalDSIEPDDTVRKQAVYrLVTE
 1113- 1145 (56.79/37.92)	ILRCRSS....TTAPPLD..DRSSQDDVLEALRVL.VVTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.28|      47|    1291|      60|     109|      12
---------------------------------------------------------------------------
   60-  109 (76.28/43.82)	TASSQATTASRHGATPR..RAAGSKLRIELSNDDNV.TPGPATdspQATPSIT
 1352- 1401 (69.00/32.98)	TLHSIYSSSSADVSTPTaaSASGASSTVVNKNVNNVgAPAAAT...TATNSIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.39|      23|     419|    1033|    1057|      14
---------------------------------------------------------------------------
 1033- 1057 (36.46/27.62)	LHTANAapVAANVNAIEFGPPRGSA
 1455- 1477 (42.93/25.70)	LHCARG..VLANPSAVPSGPMASTA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29860 with Med12 domain of Kingdom Fungi
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