<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29856

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMMGDTRDGPYKPRKSGPNAARATKLPPSIRGALLSPSKLIFNHPTTSPPLIALKLPCIRAASHNFSHRPEQPARDDAPASTAMATGDGPPLSMRPFPVADKSPKSLADFISRVNALPGGFRSVTETSLGEELDARRRRDGTTTGGGEEDAAQDDDVDMSDDANAEDEEDGDEDTAAKDPMTARMEVLKNIDIASNTAMLTLDSLSLLLSKHNPTQASLTLSQQLRELVGIGTMGADRLDDANTTPAKTRDCEAVAMGWTLMEISRTRDAAEDAAAFLGAEMAAEGRYWEGVMGVRQAGWSVCRVPGGGGGGGSGSGSDAHAPGLGVRFGFSEAAPEFQRNGLAPIRRGDDGVPWLDMGRLGGTPERLVVTYERGGKVVGRAASQELHDDDDDDEAGSLQARVLGARNTIFAQELWHELTREARLLAAYDVHPDDEKRLVCAVDADARIIVELLPASTTAAQSRPDTHDDDDENLPENTTAEAISLALHILLTYAHRCNELLRIRPLPPHVPRTRGQHVHTLLRPIIARLLYARSARSATQLVGNLVQTLRRAGITDSSFTLCTPQPTVADFAAANTGPNQPSAAVSLVRHMLQPTDFALDVTLLPSGGGGGGGDDGDDDQGVSFTVRGRTYLVPVTATYYHVLAPAGAAVHALCAPYPDGYPDLAALADYLCVVAARALAAHYLRKRRAATATAAAAAATAAATATAGDLEEEEDKDKGQQTWVLGALGTRIRHARDIDRPQLEFVVERDTAATEGGDGGAAALLRLTVSTDGQSWTWTSSSDNSAKETLEAVVDKL
Length797
PositionHead
OrganismBeauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.05
Grand average of hydropathy-0.353
Instability index41.29
Isoelectric point5.02
Molecular weight84556.27
Publications
PubMed=22761991

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29856
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.73|      41|      76|     157|     197|       1
---------------------------------------------------------------------------
  157-  197 (65.15/34.58)	DMSDDANAEDEEDGDEDTAAKDPMTARMEVLKNIDIASNTA
  236-  274 (63.69/33.65)	DRLDDANTTPAKTRDCEAVAMG..WTLMEISRTRDAAEDAA
  705-  739 (46.89/22.91)	ATAGDLEEEEDKDKGQQTWVLGALGTRIRHARDID......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     261.02|      59|     299|     301|     360|       2
---------------------------------------------------------------------------
  301-  360 (104.67/49.58)	VCRVPG...GGGGGGSGSGSDAHAPGLGVR...FGFSEAAP..EFQRNGLAP.......IRRGD.DGVPwLDMGRL
  378-  438 (80.78/33.62)	VGRAASqelHDDDDDDEAGS.LQARVLGARntiFA.QELWH..ELTRE..AR.......LLAAY.DVHP.DDEKRL
  605-  667 (75.57/31.03)	....PS...GGGGGGGDDGDDDQGVSFTVR....GRTYLVPvtATYYHVLAPagaavhaLCAPYpDGYP..DLAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.67|      22|      78|       5|      29|       3
---------------------------------------------------------------------------
    5-   29 (32.76/27.62)	TRDGPykPRKSGPNAArATKLPPSI
   85-  106 (42.91/23.90)	TGDGP..PLSMRPFPV.ADKSPKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.62|      15|     313|     141|     155|       5
---------------------------------------------------------------------------
  141-  155 (26.83/14.30)	TTTGGGEEDAAQDDD
  457-  471 (27.79/15.09)	TTAAQSRPDTHDDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.21|      28|     616|      57|      84|       8
---------------------------------------------------------------------------
   57-   84 (53.12/29.76)	CI...RA.ASHNFSHRPEQPARDDAPASTAMA
  672-  703 (37.09/18.45)	CVvaaRAlAAHYLRKRRAATATAAAAAATAAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29856 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASHNFSHRPEQPARDDAPASTAMATGDGPPLSMRPFPVADKSPK
2) FRSVTETSLGEELDARRRRDGTTTGGGEEDAAQDDDVDMSDDANAEDEEDGDEDTAAKDPMTARMEVL
61
120
104
187










Molecular Recognition Features






MoRF SequenceStartStop




1) PYKPRKSG
9
16