<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29853

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSQPSAARGTLQEAVKYWSDFVARCIVQRLDSNRFQDFVQLVHARHPLPPVLIADLFLRPQPSNRVSLDPRIPPYVRILAQLRYVDAPSILRVLYKYSALHAHDRPPLPLPSSLPENGGDGETMKKEEEEEKGAGGGGVMRQDKMVRWQESAWAEEVLFYHVIKTMFEGTAFTDAKTGLELVDITCKWMDLFVHASSELAADMLANKHDRQARDEMETVRAALVPLLLRLVDNHELLRIISKPFAKGIRKHLSESLGNFIQTVQPPPLYIERLEIFRTQTLAQLDPIDEKKKAANAAMEELLDSTVGSDNFVVPDILISNSRAALYVYLNAALVARPVLDDSMLYAFLSNKYQENQQASAVDLIVASFDVLANAVFRNEGPRDAHLLRSFVVNKLPLLLCQLCHPEFSAASAEFCITEALSRVDTGIFPTASLMFDESRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLERANRDRLVSDCLSDSGRIQNIISQLDRVDGNVGAVAHAIVELIRQLCNNKDTTSLKLLCLQLSQKPQSLDIILLFDKVTSVLEPVCTLLDNWNYEEDQGEYQPVYEEYGAILLLVFAFTYRYNLSPLDIGIQSADSHVAKIIAKSHMLRPLEDLNEQEAEHVAGWITGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIITAYTYGYINDESLKGGVEYLVDTFLLPSLVPAIRFLSDYIWIDEKEQKSIVKALQLLLTPSSISGEASTVLSAVKNLIAQPLEHALRTYQRQDPRNQDIEPLLRSLKENLPLSRRTGGPEHHEMVSWANNSNSGLSGAIRHTIQGLVQWSLQPGVNVMPTSYTHRQLITGLRIIGPSRLLRLIMEEVRQQSELGNASIVYDVAAALIAATDPTNEAPPGPNLLDTAGTMQATPPPQRPQGLREALKTAAEGCKRLQKHDQFLAEATVRLHRRVEMLLVVPQPQAMLQTTDMPLDLGGDAMAAAAAAAAAVGADPMSVDGLDTTGLDTTGLDLGLGADMGLSGGGSDGDLFGGLDTSLDMFDGWDSMDMGVN
Length1057
PositionTail
OrganismBeauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.07
Grand average of hydropathy-0.131
Instability index43.92
Isoelectric point4.93
Molecular weight116807.74
Publications
PubMed=22761991

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29853
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.29|      29|      36|     977|    1012|       1
---------------------------------------------------------------------------
  977- 1012 (39.14/36.83)	MPLDLGGDaMAAAAAaaaavGADPMSVDGLDTTgLD
 1016- 1044 (53.14/28.95)	LDLGLGAD.MGLSGG.....GSDGDLFGGLDTS.LD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.92|      27|      36|     415|     450|       2
---------------------------------------------------------------------------
  415-  442 (45.49/50.75)	FCITEAL......SRVDTgIFPTASLMFDES..RNN
  453-  487 (40.43/20.49)	FCAACALhglierDHVDR.ILGETSMSYDPSleRAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.18|      16|      37|     691|     706|       3
---------------------------------------------------------------------------
  689-  704 (25.83/17.49)	YT..YGYINDESLKGGVE
  705-  720 (22.69/14.42)	YL..VDTFLLPSLVPAIR
  721-  738 (19.66/11.45)	FLsdYIWIDEKEQKSIVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.47|      73|     230|     278|     357|       4
---------------------------------------------------------------------------
  282-  357 (109.24/110.95)	LAQLDPIDEKKKAANAAMEELLDSTVGSDNFVVPDIL...ISNSRAALYVYLNAALVArPVLDDsmLYAFLSN.KYQENQ
  506-  582 (110.23/86.50)	ISQLDRVDGNVGAVAHAIVELIRQLCNNKDTTSLKLLclqLSQKPQSLDIILLFDKVT.SVLEP..VCTLLDNwNYEEDQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29853 with Med5 domain of Kingdom Fungi
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