<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29851

Description MED2-like protein
SequenceMVVQSASVSSVHTVNSLEQEKNTETMTYKNKLTVCFDDILKVGAEMMMQQQSKNVQLDSYLVNGFSHSQQRLLKEKVKLFHGILDDLETSLNQSSSYVNTLTMLGKEKEKEREEAERRRAEEENLRKVKEQDELKKLQVLEETSQQQQSKEKNGLGLTFATKTPANTIGVNETRQNNQEPESLQPPIQTQVETTNAANNGAAFSPLATTQTQGQQGQPSDAMFNDLNSMDISMFSGLDSTAFDSTAFNPPVGGAKSLDDNNLADNYSEMNISPVENTNSNNSSNSIKNSNDNNNNNNNNNKTNDNSDNNNNHTNISVSKNNINVSKDNTSNSGNNNSNNITTNDLPTANVPNSGDNPPPAENGEEYLTLNDFNDLNIDWSTTGDNGELDLSGFNI
Length395
PositionTail
OrganismSaccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Saccharomyces.
Aromaticity0.04
Grand average of hydropathy-1.005
Instability index42.94
Isoelectric point4.49
Molecular weight43505.41
Publications
PubMed=12775844
PubMed=22384314

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
cytosol	GO:0005829	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29851
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.62|      43|      43|     197|     239|       3
---------------------------------------------------------------------------
  197-  239 (73.53/37.67)	ANNGAAFSPLATTQTQGQQGQPSDA.....MFNDLNSMDISMFSGLDS
  241-  279 (64.70/32.29)	AFDSTAFNP....PVGGAKSLDDNN.....LADNYSEMNISPVENTNS
  346-  377 (27.39/ 9.54)	........PTANVPNSGDNPPPAENgeeylTLNDFNDLNI........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.63|      17|      18|     108|     124|       5
---------------------------------------------------------------------------
  107-  123 (26.43/18.26)	E..KEKEREEAERRRAEEE
  124-  142 (21.20/13.40)	NlrKVKEQDELKKLQVLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.30|      21|      28|     143|     165|       9
---------------------------------------------------------------------------
  143-  165 (31.43/21.15)	TSQQQQskEKNGLGLTFATK...TPA
  173-  196 (32.87/16.53)	TRQNNQ..EPESLQPPIQTQvetTNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29851 with Med2 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SSYVNTLTMLGKEKEKEREEAERRRAEEENLRKVKEQDELKKLQVLEETSQQQQSKEKNGLGLTFATKTPANTIGVNETRQNNQEPESLQPPIQTQVETTNAANNGAAFSPLATTQTQGQQGQPSDAMFNDLNSMDISMFSGLDSTAFDSTAFNPPVGGAKSLDDNNLADNYSEMNISPVENTNSNNSSNSIKNSNDNNNNNNNNNKTNDNSDNNNNHTNISVSKNNINVSKDNTSNSGNNNSNNITTNDLPTANVPNSGDNPPPAENGEEYLTLNDFNDLNIDWSTTGDNGELDLSGFNI
95
395










Molecular Recognition Features






MoRF SequenceStartStop




1) NGEEYLTLNDFNDLNIDW
362
379