<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29838

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPSRLANGSGSSAHLLPRKSLRLPFHYFLTAVRDRLIDDIVSTSRKGSDARQVVRLRGGFLLGPSPASSEWSAGWEHHARTRPLIYSQLQIHLSQPPTTSSCARLLVHPVLRPTFYLPLHACLPLPSGAPITLLPHGVPAHYLHLYTGPTSALTSQFETSLMGLGAGDWKGAIEAGISIATSSASVCGDGQLPSYVIAWLSVQNKQGEDKGMPIIWPVRLCLSYHPSSPAPHARTSLPWNPELPTQLQASPPPPPPAVPLTLYNLEVQPPLYADGRTTPQQHATPRLPDTAHLRTPVSRRRRTLTSSPTAESLRAFRTMTLSTKPYARGMQNVATEVGGYVDSVAKDRDRERERMKREREGASARGRATSISGPPPNTMQLTPDVPKTEQPAVITPAATSSPAPPDDVPMDEDTGHTLDSSQDSSLNSLFSPPTDAATPFPDSVESILIPSDSHLSAEPIDLSVLQPAPEGFAADPIGTFDDAFGGFTAPWPQPTTSDFMDIGMKYDIGFNMNMDSLSHSRPGDRGGDTFDMDDGFGVFTDDDFNFFDAPAVQARPGAISTIPMQVDSVIKASEGLTPAAGPAPLGFSPQRSGDIMHISGPGPPLLSISQSSAWSHHGLAEGFTPRDFHAFDSIPPAPELLPPSPSQTPSSHSAPATPTVQLSDHDDHAGGQKLGYPSLGASIFDPIPFAPSHRINDSKYAFGKFALPSPPDDVERAQAMFFPSSGLSPAGGWRDRYSAATDPRIGIMRKLIGVKRKSFTQGVRPVRMSPSWVREHEEWESNTPSPSVEETKSDGESDDDEPWADEDEQVPDSRPSTPPPSYLPMGPTLLHTNFHHSRLLPLCSPLRPPGMVLEPPANITVPISVPTPVSPAALVGAASEKSKSLEAAAQLLVREVVENSAWADAWRINAAVSSVVPRPSAEVWQTDVKRAALLLEGVRGMQPTVDLCTLIGLEHPPPEVNGPLTSPPLIMLEPPVLAVGKADSIIQVLPTALRFWEKLGLRPRAGQKDVNAYVFYESANDEREVEIAHWLDRVSAAYSARNLGTHSAGNSAGCVRPGLVPTRFDSIKKTLVNFVATLAPMPEAYFVFYVVTPPSMVGLTSTPLRQILSAIKRTMKAHPGHGILFHFVPEAFTTGGLADPRALHGGLELFVHSVYDRILQPVERSMSRILGASGARIRSSFHAPAYALTGKIATNSGQGSNGGHMVTFRLDSHPSSLDVVDRHALLHVGYHVTPCGRWVLAACVDERGEEYELGVWLTPTESVESFVVSQVWSFSRAFAARANVEWRIVVAKLGTMGESELDAWIMHLDQAMSNLLETAPPVQVTLLTVECQNSWTLLTPTSVTGTKPTQLYTAAYSRSTPRVPSGAMFADSAYTSYAVFPLGELGCIPALSPVIKCGSGPGSADTSSISDFEDEEPLLHSQPYLRVTGSSTLISVPAGADYTAVSMVHIYRLHSVSSPKVMMPKRIDSVEVQDEEVQTLRDITHNYHALAVLAYSKWKLQEHPGLPIHLAALMTMKMALMGGGVETTL
Length1529
PositionKinase
OrganismFibroporia radiculosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporales incertae sedis> Fibroporia.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index52.36
Isoelectric point5.88
Molecular weight164953.87
Publications
PubMed=22247176

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29838
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     658.66|     115|     116|     361|     475|       1
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  250-  358 (91.34/36.55)	.................SPPPP.....PPAVP.L........................TLynlevQPPLyadgrTTPQQHATPRLP...........DTAHlrtpvsrrrrTLTSSPT...AeSLR.A.FRT..MTLSTKPYARG...MQNVATEVGGY.....VD.SVAKDR..DrerERMKRE
  361-  475 (196.94/89.13)	GA..SA....RGRATSISGPPPNTMQLTPDVP.K........................TE.....QPAV.....ITPAATSSPAPPD...DVP.MDEDTGH..........TLDSSQD...S.SLN.SLFSP..PTDAATPFPDS...VESILIPSDSHLSAEPIDLSVLQPA..P...EGFAAD
  478-  590 (144.46/63.00)	GTfdDA....FGGFTA.PWPQPTTSDFM.DIGmK........................YD.....IGFN.....MNMDSLSHSRPGDrggDT..FDMDDGF..........GV..FTD...D.DFN..FFDA..P..AVQARPGA...ISTIPMQVDSVIKASEGLTPAAGPA..P...LGFSPQ
  622-  724 (122.89/52.26)	GF..TP....RDFHAFDSIPP..APELLP..P.S........................PS.....Q.........TPSSHSAPATP....TVQ.LSDHDDH..........A..GGQKlgyP.SLGaSIFDP.......IPFAPShriNDSKYAFGKFALPSPPDDVERAQAMffP...S.....
  726-  849 (103.03/42.37)	GL..SPaggwRDRYSAATDPRIGIMRKLIGVK.RksftqgvrpvrmspswvreheeweSN.....TPSP.....SVEETKSDGESDD...DEPwADED..E..........QVPDSRP...S.TPP.PSYLPmgPTLLHTNFH......HSRLLPLCSP..........LRP...P.........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.98|      18|      87|      11|      28|       2
---------------------------------------------------------------------------
   11-   28 (34.44/18.98)	SSAHLLPRKSLRLPFHYF
  101-  117 (31.46/16.58)	SCARLLVHPVLRPTF.YL
  129-  142 (22.08/ 9.06)	APITLLPH.GV..PAHY.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      17|     127|     894|     913|       3
---------------------------------------------------------------------------
  894-  913 (22.22/22.89)	REvVENSAWADawRINAAVS
 1023- 1039 (32.36/18.33)	RE.VEIAHWLD..RVSAAYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     297.89|      95|     134|     918|    1021|       4
---------------------------------------------------------------------------
  918- 1021 (144.16/101.12)	RPSAEVWQTD.VKRAalLLEGVRGMQPTVDLCTLIGLEHPPPEVnGpLTSPPLIMLEPPVLAVGKADS....IIQVLPTAlrfWEKLGL.RPRAGQKDVNayVFYESAND
 1056- 1156 (153.73/82.57)	RPGLVPTRFDsIKKT..LVNFVATLAPMPEAYFVFYVVTPPSMV.G.LTSTPLRQILSAIKRTMKAHPghgiLFHFVPEA...FTTGGLaDPRALHGGLE..LFVHSVYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.77|      27|     116|      43|      72|       5
---------------------------------------------------------------------------
   43-   69 (43.39/28.46)	TSRKGSDARQVVRLRGGFLLGPSPASS
   74-  100 (48.38/23.21)	GWEHHARTRPLIYSQLQIHLSQPPTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.71|      47|     987|     173|     228|       8
---------------------------------------------------------------------------
  173-  200 (35.84/19.62)	................................IEAGISIATSS...ASVCGDGQLPSYVI.AWL
  206-  228 (14.20/12.00)	QGEDKGMPIIWpvRlcLSYHPSS.........................................
 1198- 1257 (71.68/34.11)	QGSNGGHMVTF..R..LDSHPSSldvvdrhalLHVGYHVTPCGrwvLAACVDERGEEYELgVWL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29838 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPPAPELLPPSPSQTPSSHSAPATPTVQLSDHDDHAGGQKLG
2) PHARTSLPWNPELPTQLQASPPPPPPAVPLTLYN
3) PPLYADGRTTPQQHATPRLPDTAHLRTPVSRRRRTLTSSPTAESLRAFRTMTLSTKPYARGMQNVATEVGGYVDSVAKDRDRERERMKREREGASARGRATSISGPPPNTMQLTPDVPKTEQPAVITPAATSSPAPPDDVPMDEDTGHTLDSSQDSSLNSLFSPPTDAATPFPDSVESILIPSDS
4) SPSWVREHEEWESNTPSPSVEETKSDGESDDDEPWADEDEQVPDSRPSTPPPSYLPMGPT
634
231
269
769
675
264
453
828










Molecular Recognition Features






MoRF SequenceStartStop




NANANA