<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29824

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGAVRSLYSS
Length97
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.03
Grand average of hydropathy-0.516
Instability index57.98
Isoelectric point9.73
Molecular weight10956.54
Publications
PubMed=16625196
PubMed=21269460

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29824
No repeats found
No repeats found











Associated diseases
Disease
Med1    osteosarcoma    PMID:24969180
Med1    breast cancer   PMID:22345290
Med1    lung cancer PMID:22342682
Med1    cancer  PMID:16574658
Med1    cancer cell lines       PMID:19521987
Med1    cancer treatment        PMID:27340176
Med1    breast cancer   PMID:17344214
metabolic diseases	PMID:24801167 PMID:20479251
neurodegenerative diseases	PMID:25564654
muscle diseases	PMID:20479251
fatty liver disease	PMID:33734012



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29824 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) ETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSS
2) HLVSCLETLQKALKVTSLPAMTDRLESIARQNGAVRSLYSS
6
57
52
97