<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29821

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAVMKMEPVQNGVRSTNHDRNLKLNGVDGGGMVKPDPDGKYFADGAANMDAVQQIQTPAQSLPADNPSRMNDLPDEIQHITENFLSISQLLSRLAQKSHNELQEKIIELAKKPLPIAPTLNGHTDHSNIDDASVENLDKKVLLLRFAQEQHAKWVKALVITEWSKKAGLVSKLIDLKGHLQQQMMTYDLALDSMMTCKRNLAYARLPSPDLKTALQVLTTGNAPWLPDFGYIEPPPLTAKDQLKWLDDINTLLSLRLTIGDHEKIPYHFRSYKISSGRVTFTVEGEFEVDLTIADEDVEKQFWFIDFRYLFAPSPAELSETFRLHLEVKVNDILASEGLAGCYKYLHELVLTHKVSELRRQALQLGRSRWVDTLKIEPLNRSLAIQYWTSRYPPNAPKNWIIIGVHSGAPPPGAQPHPKFKSYVSLRWFRNNLEIKGANVPLNLVSISTETVLKAVIARHVEQILTAIHAKLLEKPRFAKREASLGLHISKMEPTESRLTMQFTHLDTVTVRIDPITGLYALEPRLRLIPAGENSLNMFGKDPVVELERLRNIHALEELMRRGKSLGWQPIVRSPVKMEDLRSILTNREATDALGWFKRQGWNPQFFLLVSLSLSGDRWWLVELGANHPTGARIRSHVPLPFTPGQPNLGDPFFSDLTVFVTAIITQLTDVRELRSRRIRHMTRHIPSPNMPPRLKLPTILIRLSEILPSARAQLVDAGVEGGRTERRGRPWAAESVRLLVTGVQPASSDELASRGMFRAGASTRNDPYICVTASASVVVLDKSKFRLLSSKVDHDVSFSHRTGEFSLRIRAGFGESMISSLASRLQAIERLVEFLDSIGRNRQGVECESITLRKVVFTYADPSPPTPPVHSEAGASLVKPEAPVRRWKVWLDLRKPKSVKVALEPDNPHMRVLDMLQTLVNGEKGLESLPFWLPMTLSAVRGMEAVDESWQQLQISRRGMLEIFNKTLDWTTLRYTLSSSPARRLNLDVRLRQRRGEAWWHICRSDRRAAPEGDEFDKALKKVWEGKGVNWKGLSRAAAGRPAAGIEELLQVVDKAVRTVLEQPLPAAPAQHLQHQQSMAHHPPPAGSLGQTPQQIKAQQMQAQQAKAQQIQAQLQAQAKAKAQGMVGQGLANHANGSRPPHVQRPGGQVRQTRPAPQAPKGNNDVVDLT
Length1172
PositionTail
OrganismGaeumannomyces graminis var. tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Gaeumannomyces.
Aromaticity0.06
Grand average of hydropathy-0.369
Instability index51.47
Isoelectric point9.60
Molecular weight131401.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29821
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.57|      26|      33|     546|     571|       1
---------------------------------------------------------------------------
  526-  544 (24.84/11.13)	....RLRLIPAGENSL......NMFGKDP
  546-  571 (47.01/27.26)	VELERLRNIHALEELMRR.G..KSLGWQP
  577-  605 (31.71/16.13)	VKMEDLRSILTNREATDAlGwfKRQGWNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.24|      24|      27|      88|     113|       2
---------------------------------------------------------------------------
   88-  113 (31.48/26.69)	ISQLLSrlAQKSHNELQEKIIE.LAKK
  117-  141 (33.76/21.56)	IAPTLN..GHTDHSNIDDASVEnLDKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.10|      57|     174|     215|     280|       3
---------------------------------------------------------------------------
  215-  272 (98.34/55.75)	ALQVLTT...GNAP......WL....PDFGY..IEPPPlTAKDQLKWLDDINTLLSLRLTIGDHE....KIPYHFRS
  385-  447 (77.73/38.43)	AIQYWTSrypPNAP....knWI....I.IGVhsGAPPP.GAQPHPKF....KSYVSLRWFRNNLEikgaNVPLNLVS
  879-  935 (59.03/28.83)	....LVK...PEAPvrrwkvWLdlrkPKSVK..VALEP..DNPHMRVLDMLQTLVN...GEKGLE....SLPFWL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.46|      31|      34|     703|     733|       6
---------------------------------------------------------------------------
  703-  733 (52.77/40.62)	IRL..SEILPSARAQLVDAGVEGGRTERRGRPW
  738-  770 (47.69/35.82)	VRLlvTGVQPASSDELASRGMFRAGASTRNDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.74|      14|      19|      44|      57|       9
---------------------------------------------------------------------------
   44-   57 (23.93/13.96)	ADGAANMDAV.QQIQ
   65-   79 (20.81/11.25)	ADNPSRMNDLpDEIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.03|      22|      25|    1063|    1084|      10
---------------------------------------------------------------------------
 1063- 1084 (41.00/26.26)	LEQPLPAAPAQHLQHQQSMAHH
 1091- 1112 (38.03/23.79)	LGQTPQQIKAQQMQAQQAKAQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29821 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VLEQPLPAAPAQHLQHQQSMAHHPPPAGSLGQTPQQIKAQQMQAQQAKAQQIQAQLQAQAKAKAQGMVGQGLANHANGSRPPHVQRPGGQVRQTRPAPQAPKGNNDVVDLT
2) VMKMEPVQNGVRSTNHDRNLKLNGVDGGGMVKPDPDGKYFADGAANMD
1062
4
1172
51










Molecular Recognition Features






MoRF SequenceStartStop




NANANA