<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29820

Description Uncharacterized protein
SequenceMTSRPPLGVPPRQPQRSLSGPQQRLPAPPPTQRTLSQSYLPHDIADTTGTPQPRNGTLRRGGSRLKQELSNDLPISHVALSDSPNAIDHSKPFTPSRIMAMADGGPDMAAAGLSPHPSSARGLSAGMSMLDIPPYDMPHAAYPMPRRRPRFSVPDRRQKSAPAPTPPVKKDTRPKPWTFEVPAVAPRYYARGPSDASGSTTPAKAAGAPARAVSTGSAGASALAAGASADFFPWLGDHPEDQFSATVIKEGYFDKAPSTPETSSAKALVFQTLKQTTRLQGLSVVYTEVLRHRRTLGLVSSLSSFKPPPRVTLTDTKREVWVKDLANPAITLRRLSRTIPHGIRGRVLLDQCLNKKVPIERAVWLAKCVGANEIRAVRRKGTGQSAPALAMGGEAKWTRDWTVCVEQFVEGTITAIKSEDWKWRVDYAMRLARHLSFAELLDKDHYSEWLVSGLENTHLGKLPLWMILTQIHWRDILHLRKHGRRLVGAILNHLSNTQGHTDSDILQPIIGQLRWSVCRLLALAPESFVCPRTWLKHRSLIQESLPTADTSLQAAFTAVDSRNEQLASNCVRSQPAARAVLVRILDATLHSPIPKDLSNQCLAVTKDRAAVARILLEWCTSLQRPGLAKMYIAVGLLKSWAGLGLDITDTILQFLSTTSISEAERKDLVFRLVTELARADLFSTHRYVQWLIARGGLSKPSDVEMDGPCITRLLVELPDSIMNESLRSLRASMLRRASYPVKDQSLELENAIEVMKHILGMQPGPGYYARRSSGPPPMSLNNYTKRLAKTVCSVKLQVAFWLRTTFLEVLKQQQLQQQQQHLKGAVGLPSDAFFCSCRRILEACQDFTMLGDLLRALSVAPSADILASCSDTLMLHYPVFNATGVLKPLFETLLARLGPIVAEEHGSGVRRLLASLAALAGRMPGRNDLAARLSRDLNRYDRTSEIDACSPVSDNNPEAELQEEGAIEKLLASGTSIDKPTLERLFEHLVGLLHQFGDKDEERLRYPIGLLVRLRVLDPKQFDYLMAMWIRAQSRRPNRLNPLLVYPPMVSLGCLPFSLVLSALYGEMLSVSAATKTPAQPAPPINPPAGSTVNQEILQLVLRPLTDRSHVQMSTDERYRFHTLQRTVIRTNPNELLTLIRLAATEYATSSAMGKAGLPLASDKLRVALRFALMELVLNDFNTVARVLAAKHTDAGVSRIIERDMEIILMPGIEEDQRLSFDQVLELCNELTLPFCQLKLMASLASEGAITSAAGAGDPIQRLHSQLDLFARAMDKAIDARNITWTGMLSCLNPEITQHLRQKAQARFLELLPSPGRLPHLSDVEIADRVQMAESLVSVIDIIIRGGSTGKSPPLASSMVDKLTDLWEILATTAARSRAAELEFDSAEDEDETAAAIATCDAIRRHWLPQLLTFMTLHTATLDPLKASVDLRARAIIVLSGIAIELGNGEGPGYDDAHPKAPPQSSAGAADHQATPAAEATVPLSQRVLDLALVLVDNLPEEVRASVARALREHTSDARLRYLTSWTADPADRHFLVPVSLVTGAGAGQQHQPQVTAPSGATPTTPTPLSAGPDGRQPQQPPPPQQPPTQFKGRPFAPRRWELLNEPTPNIGENDSSLSLSLFRASKLQ
Length1629
PositionKinase
OrganismGaeumannomyces graminis var. tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Gaeumannomyces.
Aromaticity0.05
Grand average of hydropathy-0.208
Instability index51.30
Isoelectric point9.09
Molecular weight178708.25
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29820
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.12|      13|      31|     829|     841|       1
---------------------------------------------------------------------------
  829-  841 (26.04/14.00)	PSDAFFCSCRRIL
  861-  873 (23.09/11.66)	PSADILASCSDTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     414.32|     131|     173|      80|     252|       2
---------------------------------------------------------------------------
    1-   48 (54.37/13.05)	........................................................................................................MTSRPPLGVP....P...RQPQRSLSGPQQR.LPAP.PPTQ.R.......TL.......SQSYLPHD.IADTT
   49-  197 (204.64/137.92)	GTPQP.........RNGTLRRGGSRLKQELS.......NDLP........ISHVALSDSPnaidhSKPFTPSrimAMAdggpdMAAAGLSpHPSSARGLSAGMSMLDIPPYDMPhaayPMPRRRPRFSVPDRRQKSAPAPTPPVK.KDTRPKPWTFEV..PAVAPRYYARG.PSDAS
  198-  344 (155.30/112.30)	GSTTPakaagaparAVSTGSAGASALAAGASadffpwlGDHPedqfsatvIKEGYFDKAP.....STPETSS...AKA.....LVFQTLK.QTTRLQGLSVVYT..............EVLRHRRTLGLVS..SLSSFKPPPRVTlTDTKREVWVKDLanPAITLRRLSRTiPHGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     474.47|     131|     276|     909|    1044|       3
---------------------------------------------------------------------------
  909- 1044 (208.01/132.84)	VRRLLASLAALAG..R..........MPGRNDlAARLSrDLNRYDRTSEIDACS....PVSDNNPEAELQEEGAIEKllASGTSIDKPTLERLFEHLVGLLHQFGDK..DEERLRYPIGLLVRLRV.LDPKQFDYL..MAMWIRAQSR......RPNRLnPLL
 1067- 1151 (97.69/50.12)	.......................................EMLSVSAATKTPA.Q....PAPPINPPA..............GSTVNQEILQLVLRPLTDRSHVQMST..DE.RYRFH..TLQRTVIrTNPNELLTLirLAATEYATSS...............
 1184- 1321 (168.78/93.48)	VARVLAAKHTDAGvsRiierdmeiilMPGIEE.DQRLS.....FDQVLEL..CNeltlPFCQLKLMASLASEGAITS..AAGAG.D.P.IQRLHSQL.DLFARAMDKaiDARNITW.TGM...LSC.LNPEITQHL..RQ...KAQARflellpSPGRL.PHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.50|      59|     180|     515|     599|       4
---------------------------------------------------------------------------
  515-  543 (27.07/42.11)	....................................................WSVCRL.LALApesFVCPRTW...LKHRSLIQE
  567-  599 (43.67/13.69)	ASNCVRSQP....AARAVLVRILD........ATLHS.PIPKDLSN.......................................
  737-  818 (72.76/30.77)	ASYPVKDQSleleNAIEVMKHILGmqpgpgyyARRSSgPPPMSLNNytkrlaKTVCSVkLQVA...FWLRTTFlevLKQQQLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.19|      42|     166|     448|     497|       6
---------------------------------------------------------------------------
  448-  497 (62.13/60.26)	EWLVSgLENTHLGKLPLWMILTQiHWRDIlhlrkhGRRLVGAILNHLSNT
  617-  658 (75.07/47.33)	EWCTS.LQRPGLAKMYIAVGLLK.SWAGL......GLDITDTILQFLSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.73|      27|     118|    1451|    1478|       9
---------------------------------------------------------------------------
 1451- 1478 (46.33/27.43)	GPGyDDAHPKAPPQSSAGAADHQATPAA
 1546- 1564 (30.92/12.40)	GAG..QQH...QPQVTAPSG...ATPT.
 1572- 1597 (51.48/26.19)	GP..DGRQPQQPPPPQQPPTQFKGRPFA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29820 with Med12 domain of Kingdom Fungi
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