<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29816

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDATMDPGMAVDLEEVDLFGDPVAVSLMSATRPPPSKQLLSRLDEMRGRGCCQKIAWSRQGTIASVSADGRSVDLRYLRSHPDDAAWGLSDSTTYSSFGSVAPQTGGGQIAHLAWASSGNPELAVVDDVGRVSFIQCPVSLNRAFTTRTWDADPVDELGAVVGCYWLPLATPGKQQYTALQGPAVREGNGWRYETSYKPAIGPSHPNPSKSAFVCITAGGTLKMFYSQPNNKIQETSLELENIGGSDDLITHASICPDRSSSGLCITLALTSRLLKLVKVAINWGLPPQVDKQNPPNTHPLNPTFKEKRMAVVSWMPLGGPPPGPEPPLDISMAHISLLELLPTTLGPNNQQGFVPPLILAVRSHVSPFSHIVQSVLDVWEIVDDQAQSAQPQALHSAFQQLSSRTGAPAPQPATRLHRLDPIWLDKVAVSIQLLHPGRVICLVFSDGTVQHRDRHTLEVMYASPDLERVSALDGLGFRFADETPCLQAAFSPTSCSFVQVCEDSKVRWNSLRYPAADIGSTTQDAQYYAVVAGLAMSVAAASSHTNYDDILAIGRQFIDKPRFAYDWVMEVARVLKIHIDYSEEAHHDQLVRNHHLQLCLSILHHMGLYGEFRPRSFGGKFGAVALGIRSIVILITIASHTYKADKLVPLDEPDVVDALATGSKWTLDVLSWLAESLFDLADDAKFEALLNPTDWKNVMEYLHSRNNDIALHLLLCSSTRGFIQAACRRLIHLDSLSHRATDYYEKNYTQAPGQDSSAVPSNRLHLSYQRMQRYTSSSLIKVAEFGELLSVLGSEIRSAYEVMLRPLAERQRLQQRQQQQQQQQQGPNGNKTQQQQQQQGGPDQAVKRAQAQCELSLLLGNAPPNGFIPVLKKFFFEVNLPAFRAQTDRAQLFFADFTLLDVLDDRRSLQERRARGKHVDAFKRSEIELAPRNDGAVASATGRQQQPGANGSTGVLLRRRCVRCAAVMEDVTAQKPAVTLVVAQQRKCPCGGSWGLLAKGATAG
Length1005
PositionTail
OrganismGaeumannomyces graminis var. tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Gaeumannomyces.
Aromaticity0.07
Grand average of hydropathy-0.242
Instability index45.14
Isoelectric point6.74
Molecular weight110340.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29816
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.15|      45|     108|     784|     854|       4
---------------------------------------------------------------------------
  784-  830 (71.20/69.84)	AEFgELLSVLGSEiRSAYEVMLRP............LAERQRLQQRQQQQQQQQQGPNG
  896-  952 (69.95/26.66)	ADF.TLLDVLDDR.RSLQERRARGkhvdafkrseieLAPRNDGAVASATGRQQQPGANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      13|      18|     548|     560|       5
---------------------------------------------------------------------------
  548-  560 (23.72/19.01)	YDDILAIGRQF...ID
  566-  581 (19.23/13.81)	YDWVMEVARVLkihID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.54|      20|      26|     303|     328|       6
---------------------------------------------------------------------------
  309-  328 (44.41/28.32)	RMAVVSWMPLG....GP..PPGPEPP
  332-  357 (27.13/ 6.40)	SMAHISLLELLpttlGPnnQQGFVPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29816 with Med16 domain of Kingdom Fungi
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