<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29815

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMVQVTQYDNVGGQSSKEVVANELKSLSNTLKQIHTVSTASSTRLPHVPTELIQYVENGRNPDIYTREFVEVVRRGNQLMRGKLHAYESFRDILAGEMRTALPELRDDVDQVIAATTPAPAPAPAPARGVSNNTTPAAAAAQHPAAAARHSGRLDGDKTESDSYGGLPTPPSFGIDSTPPTPTTPTSQATPSRRGAGRGRGRGRGAKGAGRGTRGAGRSGRGGRRGGAANDENVARSGGNNSGAATRRSSRIESARNAAQQIQNSGLAGVAEELLVRHGAQRQLVGAGAYHKTRMATILGARFAHSAAGLLIDFGLTAAFAAASLFVLGIHGVFHAIAYAFVTPWLALMRVLGTIKLSFIVAGRIMRICGRLLIILLRWATTYRGHRLFFLDPLTMEAMMPSSPVPHVEDEDEAEVEFESDEDEGLFVDEADLETREDEFTEEAPLPVFC
Length449
PositionMiddle
OrganismGaeumannomyces graminis var. tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Gaeumannomyces.
Aromaticity0.06
Grand average of hydropathy-0.296
Instability index39.59
Isoelectric point7.23
Molecular weight47939.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29815
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.72|      15|      15|     111|     125|       1
---------------------------------------------------------------------------
  111-  125 (28.69/13.00)	VIAATTPAPAPAPAP
  129-  143 (28.04/12.58)	VSNNTTPAAAAAQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.33|      10|      15|     217|     228|       2
---------------------------------------------------------------------------
  217-  228 (16.01/12.29)	RSgrGGRRGGAA
  235-  244 (19.32/ 7.55)	RS..GGNNSGAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.48|      17|      18|     336|     352|       3
---------------------------------------------------------------------------
  318-  331 (17.19/ 9.11)	...AFAAASLFVLGIHG
  336-  352 (29.81/21.22)	IAYAFVTPWLALMRVLG
  354-  369 (27.49/19.00)	IKLSFIVAG.RIMRICG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      14|      15|      45|      58|       5
---------------------------------------------------------------------------
   45-   58 (26.30/19.74)	PHVPT.ELIQYVENG
   61-   75 (20.91/14.30)	PDIYTrEFVEVVRRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.76|      12|      18|     255|     268|       7
---------------------------------------------------------------------------
  255-  268 (13.74/16.36)	RNAAQQiQNSGlAG
  276-  287 (23.01/13.96)	RHGAQR.QLVG.AG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29815 with Med10 domain of Kingdom Fungi
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