<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29805

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGDYDTNSLLINDVASISFRVYEPVLSSSIYTFAASDVERALRREGHLVYADSVRRVLWCFFLVGKDASQVAPSDLAQTLEICGYKLNKVTDGTFDPISLLKTRPSTTNAMNTPSSSSSTGSALDQPARSTQPAQSGSSPVWPSGPTDYETKHDPRGSSSVPAKEVYEYFVSAVLSSLSAAFCAKIGAIALNSRSLLLPRAASPLDDGTVGPNQPRAILATFRVYLTTTGSLVIGLALSVMNGIMSCAERMATNPIPARIPVLVAPLGAYGTLQSSFDPTSGFDQHSVQSPDTQITRPRPDTDERMARWRRDCIKILEMRGVSPSVLSGTSWVSIQSLRKRASEHKVDGKRTPGGATAGTSTVFWPSVLCFHRTSRSDRPSSLSSEALGVAEVAAMDPLTNARAWLMGAEERDGLLLRRQKEREALASRVTADGDARAQPSNGYSPLKLRRQSNSNAVPLPGTMYPTPPDGVQNPAAATSYLDGTVSSPANAPGVALIASAADVDVVMTQADAGPAGGFGDGWEGGDVKRADPEFLGDMGADIFGDNDITDADFSFFDEQPGGGDMDFSGLSSMGVAMEAPSNTSLSFGTYPQKPVEPVALPQVIPLPPVFAKPELKHARSSLVDESRFGNDDTRLRRQPSGGVKRQPSPFDPDTVFKRVRASLESTSALSNRNLHPSRRGSVFEKVDFDPYLALNNKKYQENGRFGCRWDVKKENRANDAASPPTTDYLRRHGNRRNKLKELPSSNVGALLAKITGDLETSSLQPSPDKMDDPPSDADDVSLVSDQDDTSYTSEEPTSPTRSVATRRRPEDDAISLATSLRELDTAGASSPQVSVDLSRFANNEPPELPLARWFAEPEPTGLSGSYGDDDYIMIAQILTEQAALGMLKLAAAPHADSEFSNPRETRRKISTCARYSLRVLRSVLPPSLSGALECRFKPLLDVQDIPLVGPPSRLPPRPTGAPEQTRPNLFQIPPPQFELRRHETRLSLLPSCTDFWESLGLGPSQGPKDVLAVCVFPEWEGLLDHVDNFLNRTRTVYDSLKLGSFERLPTVGGLSDGLVPYEVGGSSPIESPSSVVARPGSVVADRMSKLSQALAATAASEKNFVVYYVYTPSNPTSIVDCCAAFQRLFELYKKLLSDKRAQSNNELVMQLLPLDMVASASSLAIPAPSEYVRLCLETYDRCTLFDGTMPAPAIILEQPLPRHIEFKLTSASSTNVLYENSCIHIAYAQSVDERWMTVAWTDNRGIKQMTASYCLGRRDRPLSTPFAKVAQEIWDTTEELISAWRVHWQLIVTKCGPMDQQEVDTWVALQQGETKVPSISLTLLTVDTDPSLLLVPPPARIALTTTNTLYTTPASTPQASVMSPEQVNGPATPLGTGPTSGPANPTTPGTEPSAVDPDIDTTLVDMTDATWGAILSHRLNNAASLTDLTPALVSGYLVKRGGTRLEDPPVAMELNVIYTEGNPRMYEALLREMLSYFRGLGSLARARGVVDRDVDIRPWHIAAAEKGIHALHQLL
Length1518
PositionKinase
OrganismGaeumannomyces graminis var. tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Gaeumannomyces.
Aromaticity0.07
Grand average of hydropathy-0.312
Instability index50.27
Isoelectric point5.31
Molecular weight164400.27
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29805
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1122.33|     333|     361|     106|     466|       1
---------------------------------------------------------------------------
    3-  347 (432.61/222.26)	........................................PGD....YDTNSLLINDVASIsfrvyEPVLSSSIYTFAASDveralrREGHLVYADSVRRVLWCFFLVGKD....AsQVAPSDLAQTLeicgyKLNKVTDGTFDPISlLKT...................................RPSTTNAMNTPSSSSSTGSALDQPARSTQPAQS.G..SSPVWPSGPTD.YETKHD..PRG..SSSVPAKEVYEYFVSAVLSSLSAAFCAKIGA.......IALNSRSLL..L...PRAA....SPLDDGTVGPNQPRAILATFRVYlttTGSLVIGLALSvmngimscaermatnPIPariPVLVAPLGAYGtlQSSFDPTSGF...DQHSVQSPDTQITR.PRP.DTDERMARWRR..DCIKILEMRGVSP....SVLSGTSWVSIQSL.RKRASEH
  348-  705 (450.42/209.19)	KVDGKRTPGGATAGTstvfwPSVLCFHRT..SRSDR....PSS....LSSEALGVAEVAAM.....DPLTNARAWLMGAEE......RDGLLLRRQKEREALASRVTADGD....A.RAQPSNGYSPL.....KLRRQSNSNAVPLP.GTM...................................YPTPPDGVQNPAAAT...SYLDGTVSS..PANApG..VALIASAADVDvVMTQADagPAGgfGDGWEGGDV.........KRADPEFLGDMGAdifgdndITDADFSFFdeQ...PGGGdmdfSGLSSMGVAMEAPSNTSLSFGTY...PQKPVEPVALP............qviPLP...PVFAKPELKHA..RSSLVDESRFgndDTRLRRQPSGGVKRqPSPfDPDTVFKRVRAslESTSALSNRNLHPsrrgSVFEKVDFDPYLALnNKKYQEN
  711-  975 (239.29/99.09)	RWDVKKENRANDAAS.....PPTTDYLRRhgNRRNKlkelPSSnvgaLLAKITGDLETSSL.....QPSPDK....MDDPP......SDA.......DDVSLVS....DQDdtsyT.SEEPTSPTRSV.....ATRRRPEDDAISLA.TSLreldtagasspqvsvdlsrfanneppelplarwfaEPEPTGL....SGSYGDDDYIMIAQILTEQAAL.GmlKLAAAPHADSE.FSNPRE..TRR..KISTCARYSLRVLRSVLPPSLSGALECRFKP.......L.LDVQDIP..LvgpPSRL....PPRPTG..APEQTRPNL..FQI.....................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.66|      86|     360|     976|    1075|       2
---------------------------------------------------------------------------
  976- 1075 (126.96/104.04)	PPP.QFELRRHETrLSLLPSCTDfwES..............LGLGPSQGPKDvlavcvfPEWEG.....LLDHVDNFL.NRTRTVYDSLkLGsfERLPTVGGLSDgLVPYEVGG......SSPIESP
 1339- 1451 (123.70/67.48)	PPPaRIALTTTNT.LYTTPASTP..QAsvmspeqvngpatpLGTGPTSGPAN.......PTTPGtepsaVDPDIDTTLvDMTDATWGAI.LS..HRLNNAASLTD.LTPALVSGylvkrgGTRLEDP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29805 with Med13 domain of Kingdom Fungi
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