<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29779

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEDSYLALRELVEKSRVEAEGKNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEILHSGSYRRMPKCVEEIGTQNTLFQDEQKPTLKKLNTLVRTKLLETSLPKEVSEVSVTDGIANVQVDGEFKVLITLGYRGHFSLWRILHMELLVGEKTGPIKLEETRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNALRQGRWKDAIKSELISDIHSGGGQGGNSALMQLGQEGELDSSGSRIPGLKINYWLEEKTNASAELDSSPFIKIEAGQDMQIKCQHSSFVLDPFTDKEADLSIDLSCIDVEAVILKAIACNRHTRLLEIQRELIKNVQMSQSRTEVILKREVHGVGFQKKAHRRDSDDCSTNEMLQARAYGQSYIHLGINIRNGRFLLQSPGNILPPSAVLESEEALNKGITTATDVFVSLRTRSILHLFAATGSSLGLKVYSQSQVTLKIPKSILYGSDFMVMGFPQCANAYYLLMQLNNSFQPVFHLLEIQSNEGDKNNADASTDAKEVIRFIRIDINKLKIDEDVQIGSLFDKDKLLALPNVEDRPQRLSGTFALLPARPSFSSVVDEVFGFDTGSPKTENQRLPSYNLPSSHSSYQVGLRGANGGAGSPVQDYGSLQSNINSAKVTSSISLNNYLLNNSKHAQSTTALFGSVPAGSGNISSSRSEGASRKRSLSEFLQNIPLLKQSDRPSKRRNMSEFMLDGPLKAHSPNMQPGTTLTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSLNIPHVEEAGLRTPSSNLWLRLPFAHDASWKHICLRLGKAGSMSWDVRINDPHYGALWKLHGGSTSTEWGSGIRVANTSEVDSHISFDDDGVLLTYNTVEADSVQRLVSDLQRLSNARAFSCGMRRLIGVKLDDELVENQAAAETKLYPRRKASSDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWEAGKSGCTMRVSPDQLWPHTKFFEDFVNGDEVASFLDCIRLTAGPLLALGGAIRPAKMPVTVPAVYSVVPKQNNVLSSVGSTNSSLSSSVHNMSVPQGAAVAQANSHLQTSSMLSAAGRTAPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNLLSARHTGPQLNASASTVSGSQQLAPTTNRFGGAPGVARPTSSVGNQVATSLSRAGNAMMASGFSSGIAGAPAHLSPANNIPAHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQASQSNNGQEELTASEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFIKLIAWKKNLSQAHGDNATAQRARIELCLEKHPRLVSDDYTLSSSSKSNIHHDRANNSVEFALTFVLDQALVPQMSISGGAAWLPYCVSVRVRYTFGDNSHIAFLAMDGSHSGRACWLQHEDWERCKQRVSRAVETMNGSAAVGDMSQGRLRMVAEMVQKQLQLSLVQLRDGPGSAVS
Length1681
PositionTail
OrganismOryza brachyantha
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index49.28
Isoelectric point8.31
Molecular weight184829.44
Publications
PubMed=23481403

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29779
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1407.54|     470|     575|     256|     765|       1
---------------------------------------------------------------------------
  256-  765 (689.96/555.90)	ILYTILH.ELCISLVMDTVirQTNALRQGRWKDA....IKSELISDIHSGGGQGGNSALMQLGQEGELdSSGSRI..PGLKiNYWLEEKTNASAELDSSpfIKIEAGQDMQikcQHSSF....VLDPFTDKEADlSIDLSCIDVEAV.ILKAIACNrHTRLL..EIQRELIKNvqMSQSRTEVILKREVHGVGFQKKaHRRDSDDCSTNEMLQARAYGQ.SYIHLGINIRNGR...FLLQSPGNILPPSAVLesEEALNKG.ITTATDVfVSLRTRSILHLFAA.TGSSLGL...KVYS....QSQVTLKIPKS.ILYGSDFMVMGFPQCANayylLMQLNNSFQPVFHLLEI.QSNEGDKNNADASTDAKEVIR...FIRIdINKLKIDEDVQigsLFDKDKLLALPNVEDR..PQrLSGTfalLPArPSFSSVVDE..VFGFDTGSPKTENQRLPSYNLPSSHSSyqvgLRGANGGAgsPVQD.YGSLQsniNSAKVTSSISlNNYLLNNSKHAQSTTAL.FGSVPAGS.GNISSSRSEGASRKRSL
  831- 1339 (717.58/459.09)	LLHVIKHcSICIKYAQLTA..QMDSLNIPHVEEAglrtPSSNLWLRLPFAHDASWKHICLRLGKAGSM.SWDVRIndPHYG.ALWKLHGGSTSTEWGSG..IRVANTSEVD...SHISFdddgVLLTYNTVEAD.SVQRLVSDLQRLsNARAFSCG.MRRLIgvKLDDELVEN..QAAAETKLYPRRKASSDRLSEQ.MRKTFRIEAVGLMSLWFSYGAvPMVYFVVEWEAGKsgcTMRVSPDQLWPHTKFF..EDFVNGDeVASFLDC.IRLTAGPLLALGGAiRPAKMPVtvpAVYSvvpkQNNVLSSVGSTnSSLSSSVHNMSVPQGAA....VAQANSHLQTSSMLSAAgRTAPGLVPSSLLPFDVSVVLRgpyWIRI.IYRKKFSVDMR...CFAGDQVWLQPATPPKggPS.VGGS...LPC.PQFRPFIMEhvAQGLNALEPNLLSARHTGPQLNASAST....VSGSQQLA..PTTNrFGGAP...GVARPTSSVG.NQVATSLSRAGNAMMASgFSSGIAGApAHLSPANNIPAHMKGEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.44|      14|      19|     766|     781|       7
---------------------------------------------------------------------------
  766-  781 (21.14/17.54)	SEFLQNIPLLKQSdrP
  788-  801 (27.30/15.43)	SEFMLDGPLKAHS..P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29779 with Med14 domain of Kingdom Viridiplantae
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