<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29726

Description Uncharacterized protein
SequenceMQCHLQPKQWIWLSLIFTLLSAEVVGLPGGGNPQPPHLFGAAHVPGVGPDVFPPPPPAAPKDSKGTGSQHGKNSYVNPDLDHPIAPAPSAAPPANPPPAKPPAAHPANSPAAPPAGPPANSPPANPPAAHPANPPPAPPANPPAAHPANSPAAPPAGPPANSPPANPPAAHPANPPPAPPANPPAAHPANSPAAPPAGPPANFPPANPPAAHPANPPAAPPANPPAAHPSKPPAAHPAKPPAAPPAKPPAAPPANPPAAHPANSPPAKPPVAHPDNSPAVPGTKGVPSTPTNAPPLVVPGVPKTGKTSAVKNNPSVNPAHPFPETKQRSGIQTPLVPPVISGAPKPTDQASVISKSPPEKPVSPPPGTKQTIFVPPVVPAAPKPTDQASVISKSPSEKPVSLPSGMKQTPPVPPVIPGAPKSTDQASVISKSPPEKPVSPPPGTKETPSVPPVVPAAPKPTGQASVISNIPSAKPISPPPGTTQTPSTPPVPPGTAQTTAKLSTAKVSSSVRPNPVQSGTKQKPDVPTDAPRPSSPSPNITKDQPPVVPSTLSTKPGSQETVSRKQSGSIGPKLETTDVPQQTVNQVTNTIAPTVNGTPTVVPVVAPIPIPKPKPSVPPQPPAPPKQEDDHKKDDGKKDDDKDDDEKDDGNKKGDDGDDNKPPHINPPPVIVSPPKVNPPPKIGPPKIGPPKIGPPKIDPPKIGPPKIDPPKIGPPKIDPPKIGPPKIGPPKIDPPKVNPPPKVNPPPKDNPPPKVNPPPKDNPPPKDNPPPKVNPPPKVGPPVVDPPEDKKPTPSQEPSKTAKSTLTKTTTATSQASTTSQASTTSQASTTSQASTMSCPSAVPSGDPKNGNGKNKDCPARRKLCSQECAACRSEEVPRPPGLTKRDIERLEKSSISESDSGYPGHLAKRRMGTPADYNNDLKNFFFNELKVAALVPKGFWIDPGAAMPRNQPSVLVAELGKQKFNAGIINLRGCTSVLVISSAGMWWAHFWEAPGFRYQSLMAGYRFNEEIFKKNVLDVLDAGCSYRTVNNDRVVTTRTTASVRCFVGGTRENPKRFDPVYAPVAFIFTPEDYEKAGQPLYAPEVQRIRDKLHEILGPGTPITTITHKTVDRLGDSPSFQLPTGAYLPYGKALLQYDPREEERDCRWWAGAKVYAEENPTPYHRSLWPARPNQLMTPAAQKRAAPDLAGLPASCSLPVKSKTSKSPTKTTSKPKSTKVASTLIKSVKTTGKPESTKQPSTTTQKPKTTHPKTTKAPTSTSKSEPKPATTTSREPPPKEEESREQKEEKKKEEEEKKKEEEEKKKEEEKKKKEEEKKKEEEEKKKEEEEKKKEEEKKKEEEKKKEEEKKKEDKKEDKKEELNAVCNAFFFRGRGETLITVSSIKGWKGGDEFRSKLEDKCGEIKHWGFKDDTARFNIKDVGRVSCVSKAVEAAGGPRTTCRAPIGA
Length1447
PositionTail
OrganismCoccidioides immitis (strain RS) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.04
Grand average of hydropathy-0.891
Instability index65.25
Isoelectric point9.48
Molecular weight152583.26
Publications
PubMed=19717792
PubMed=20516208

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP29726
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     395.76|      38|      38|     110|     147|       1
---------------------------------------------------------------------------
  105-  129 (51.91/ 6.87)	HPAN....................sPAAPPAGPPANSPP.ANPPAA
  130-  170 (87.30/18.85)	HPANPPP...APP.ANPPAAHPansPAAPPAGPPANSPP.ANPPAA
  171-  211 (86.17/18.47)	HPANPPP...APP.ANPPAAHPansPAAPPAGPPANFPP.ANPPAA
  212-  235 (55.16/ 7.97)	HPANPPA...APP.ANPPAAHP..................SKPPAA
  236-  272 (65.86/11.59)	HPAKPPA...APP.AKPPAAPPanpPAAHPA....NSPP.AKPPVA
  664-  703 (49.37/ 6.01)	H.INPPPvivSPPkVNPP...P..kIGPPKIGPPKIGPPkIDPPKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     317.08|      35|      35|     337|     371|       5
---------------------------------------------------------------------------
  299-  340 (49.32/ 9.37)	PGVPK.TGKTSAVKNNPSVNPAHPFPETKQRsgiqtplvPPVI
  341-  378 (69.71/17.28)	SGAPKPTDQASVISKSPPEKPVSPPPGTKQT.....ifvPPVV
  379-  416 (62.52/14.49)	PAAPKPTDQASVISKSPSEKPVSLPSGMKQT.....ppvPPVI
  417-  454 (69.02/17.01)	PGAPKSTDQASVISKSPPEKPVSPPPGTKET.....psvPPVV
  455-  492 (66.51/16.03)	PAAPKPTGQASVISNIPSAKPISPPPGTTQT.....pstPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.49|      18|      18|    1311|    1328|       6
---------------------------------------------------------------------------
 1311- 1328 (33.53/20.18)	KKKEEEKKKEEEEKKKEE
 1331- 1348 (32.96/19.71)	KKKEEEKKKEEEKKKEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.88|      17|      18|     808|     824|       9
---------------------------------------------------------------------------
  808-  824 (26.38/ 9.90)	TKTTTATSQASTTSQAS
  826-  842 (28.49/11.47)	TSQASTTSQASTMSCPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.76|      16|      19|     626|     642|      10
---------------------------------------------------------------------------
  626-  642 (25.21/18.17)	KQEDDHKKDDGKkDDDK
  646-  661 (29.55/16.83)	EKDDGNKKGDDG.DDNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     211.53|      28|      44|      32|      59|      11
---------------------------------------------------------------------------
   32-   59 (54.17/15.67)	NP.......QPPHLFGAAHVPGVGPDVFPPP...PPAA
   77-  104 (47.02/12.09)	NP.......DLDHPIAPA..PSAAPPANPPP.akPPAA
  514-  548 (36.16/ 6.65)	NPvqsgtkqKPDVPTDAPRPSSPSPNITKDQ...PPVV
  555-  582 (35.44/ 6.29)	KP.......GSQETVSRKQSGSIGPKLETTD...VPQQ
  763-  785 (38.74/ 7.94)	NP.............PPKDNPP..PKVNPPPkvgPPVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.17|      18|      18|    1048|    1065|      13
---------------------------------------------------------------------------
 1048- 1065 (34.67/19.67)	FVGGTRENPKRFDPVYAP
 1068- 1085 (34.50/19.54)	FIFTPEDYEKAGQPLYAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.81|      28|      48|     941|     976|      16
---------------------------------------------------------------------------
  941-  976 (37.72/41.50)	FWIDPGAampRNQPsvLVAelGkQKFNAGIIN......L.RGC
  992- 1026 (47.10/24.96)	FWEAPGF...RYQS..LMA..G.YRFNEEIFKknvldvLdAGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.00|      15|      18|    1385|    1402|      17
---------------------------------------------------------------------------
 1385- 1399 (28.00/21.58)	KGWKGGDEF.RSKLED
 1405- 1420 (25.00/ 9.25)	KHWGFKDDTaRFNIKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.75|      13|      38|    1140|    1152|      20
---------------------------------------------------------------------------
 1140- 1152 (27.48/14.40)	PREEERDCRWWAG
 1161- 1171 (18.11/ 6.42)	PTPYHRSL.WPA.
 1179- 1191 (21.16/ 9.02)	PAAQKRAAPDLAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.92|      12|      68|    1279|    1290|      21
---------------------------------------------------------------------------
 1279- 1290 (19.72/11.79)	KEEESREQKEEK
 1350- 1361 (19.19/11.26)	KKEDKKEDKKEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29726 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAACRSEEVPRPPGLTKRDIERLEKSSISESDSGYPGHLAKRRMGT
2) PTPYHRSLWPARPNQLMTPAAQKRAAPDLAGLPASCSLPVKSKTSKSPTKTTSKPKSTKVASTLIKSVKTTGKPESTKQPSTTTQKPKTTHPKTTKAPTSTSKSEPKPATTTSREPPPKEEESREQKEEKKKEEEEKKKEEEEKKKEEEKKKKEEEKKKEEEEKKKEEEEKKKEEEKKKEEEKKKEEEKKKEDKKEDK
3) VVGLPGGGNPQPPHLFGAAHVPGVGPDVFPPPPPAAPKDSKGTGSQHGKNSYVNPDLDHPIAPAPSAAPPANPPPAKPPAAHPANSPAAPPAGPPANSPPANPPAAHPANPPPAPPANPPAAHPANSPAAPPAGPPANSPPANPPAAHPANPPPAPPANPPAAHPANSPAAPPAGPPANFPPANPPAAHPANPPAAPPANPPAAHPSKPPAAHPAKPPAAPPAKPPAAPPANPPAAHPANSPPAKPPVAHPDNSPAVPGTKGVPSTPTNAPPLVVPGVPKTGKTSAVKNNPSVNPAHPFPETKQRSGIQTPLVPPVISGAPKPTDQASVISKSPPEKPVSPPPGTKQTIFVPPVVPAAPKPTDQASVISKSPSEKPVSLPSGMKQTPPVPPVIPGAPKSTDQASVISKSPPEKPVSPPPGTKETPSVPPVVPAAPKPTGQASVISNIPSAKPISPPPGTTQTPSTPPVPPGTAQTTAKLSTAKVSSSVRPNPVQSGTKQKPDVPTDAPRPSSPSPNITKDQPPVVPSTLSTKPGSQETVSRKQSGSIGPKLETTDVPQQTVNQVTNTIAPTVNGTPTVVPVVAPIPIPKPKPSVPPQPPAPPKQEDDHKKDDGKKDDDKDDDEKDDGNKKGDDGDDNKPPHINPPPVIVSPPKVNPPPKIGPPKIGPPKIGPPKIDPPKIGPPKIDPPKIGPPKIDPPKIGPPKIGPPKIDPPKVNPPPKVNPPPKDNPPPKVNPPPKDNPPPKDNPPPKVNPPPKVGPPVVDPPEDKKPTPSQEPSKTAKSTLTKTTTATSQASTTSQASTTSQASTTSQASTMSCPSAVPSGDPKNGNGKNKDCPA
870
1161
24
915
1358
861










Molecular Recognition Features






MoRF SequenceStartStop




1) PKIGPPKIDPPKIGPPKIDPPKIGPPKIDPPKIGPPKIGP
691
730