<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29719

Description Uncharacterized protein
SequenceMAFKGKSDDEMNTDRLTQCLDDIMRAATEMMVQQQLKTIQLNSDVAAGFRKNFSKSLGDKVRLFHSILDGVDTTLTTASQYLETVDDVAHRMKQWKLRQEEELRRKQQEELEKTKKLQEEKAAAQVALLAPQHLTQQAHHQSPVDLTGATPNGLMADLEATNLEGQDSNRGGSKKPFSADFGDLNDMDLSMFGGIDGQGDFSLDDFNMGSGSVPSNSNNGDTGENINELDSNSGIGSAATSSRIITNNNGNNGNNGNNNNNNNNNVSNSNNNSNNNSNNNSNNSNNNSNNNSNNNSNNNNNITNTSEKNNGRGCITHNDNNNIGLNTSNTNNINEQNVNSGLRADIVDQDTRQPGAQTGSGINPDDYLTLNDFNDLGIDWNTTGDNNELDLNDFNI
Length396
PositionTail
OrganismEremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.04
Grand average of hydropathy-1.063
Instability index24.44
Isoelectric point4.46
Molecular weight43140.49
Publications
PubMed=22384365

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
cytosol	GO:0005829	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29719
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.93|      20|      20|     261|     280|       1
---------------------------------------------------------------------------
  261-  280 (42.60/12.96)	NNNNNVSNSNN.......NSNNNSNNN
  282-  299 (38.97/11.21)	NNSNN..NSNN.......NSNNNSNNN
  300-  326 (28.36/ 6.09)	NNITNTSEKNNgrgcithNDNNNIGLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.93|      18|      19|     357|     374|       2
---------------------------------------------------------------------------
  357-  374 (31.41/11.56)	QTGSGIN...PDDYLTLNDFN
  375-  395 (24.52/ 7.37)	DLGIDWNttgDNNELDLNDFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.11|      26|      28|     203|     228|       3
---------------------------------------------------------------------------
  166-  203 (35.34/14.53)	QDSNRGGSKKPFSA.....DFGDlndmdlsmfggiDGQGDFSL
  204-  229 (48.01/22.78)	DDFNMGSGSVPSNS.....NNGD............TGENINEL
  230-  258 (31.76/12.20)	DS.NSGIGSAATSSriitnNNGN............NGNNGNN.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29719 with Med2 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKAAAQVALLAPQHLTQQAHHQSPVDLTGATPNGLMADLEATNLEGQDSNRGGSKKPFSADFGDLNDMDLSMFGGIDGQGDFSLDDFNMGSGSVPSNSNNGDTGENINELDSNSGIGSAATSSRIITNNNGNNGNNGNNNNNNNNNVSNSNNNSNNNSNNNSNNSNNNSNNNSNNNSNNNNNITNTSEKNNGRGCITHNDNNNIGLNTSNTNNINEQNVNSGLRADIVDQDTRQPGAQTGSGINPDDYLTLNDFNDLGIDWNTTGDNNELDLNDFNI
120
396










Molecular Recognition Features






MoRF SequenceStartStop




1) DFSLDDFNM
2) INPDDYLTLNDFNDLGIDWNTTGD
3) LDLNDFNI
4) SKKPFSADFGDLNDMDLSMFGGIDG
200
362
389
173
208
385
396
197