<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29697

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPASAPVPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNATDREDSPVVALLLQQFKENVQDLIYRTKPGKQTKTGTKRKVCDDPCPVESKKTKRSGETCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQIEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLMSQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQVIYCWD
Length1436
PositionTail
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.07
Grand average of hydropathy-0.192
Instability index51.97
Isoelectric point8.92
Molecular weight158945.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29697
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     246.27|      32|      32|    1036|    1067|       1
---------------------------------------------------------------------------
   14-   46 (43.16/13.38)	PGGGGGGSGGP.aSAP.VPPPPGAAVAAAAAAAAS
 1036- 1067 (56.97/19.73)	PSMMHTQSPGN..LHA.ASSPSGALRAPSPASFVP
 1070- 1101 (49.59/16.34)	PPSSHGISIGP..GAS.FASPHGTLDPSSPYTMVS
 1102- 1123 (28.44/ 6.62)	PSGRAGNWPGS...PQ.VSGPSPATR.........
 1125- 1155 (34.49/ 9.40)	PGM....SPANpsLHSpVPDASHSPRAGTSSQTMP
 1173- 1202 (33.62/ 9.00)	IPTILTHSALN..ILL.LPSPTPGLVPGLAGSY..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     246|     275|       2
---------------------------------------------------------------------------
  246-  275 (48.89/34.41)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/31.70)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      30|    1326|    1351|       3
---------------------------------------------------------------------------
 1326- 1351 (43.68/28.00)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1355- 1380 (39.36/19.27)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.19|      29|      30|      69|      97|       4
---------------------------------------------------------------------------
   69-   97 (46.39/37.45)	LTDLLPRKSDVERKIEIVQFASRTRQLFV
  102-  130 (48.79/39.83)	LVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.92|      85|     508|     365|     523|       7
---------------------------------------------------------------------------
  340-  448 (127.49/151.01)	WNQQV...LGRKTGTASV.HKVTIKID....EndvskplqiFHDPPlpasdsklveramkIDHLSIEKLLIDSVHARAH.QKLQElKAILRGFNANENSSIETALPALVVPI.LEPCGN
  492-  540 (30.60/45.49)	WIQQLkfwLGQQRCKQSIkHLPTISSEtlqlS........nYSTHP..............IGNLSKNKLFI................................................
 1208- 1258 (57.83/ 8.47)	..................................................................ERFL.GSVIMRRHlQRIIQ.QETLQLINSNEPGVIMFKTDALKCRVaLSPKTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.52|      12|     156|    1002|    1018|       8
---------------------------------------------------------------------------
 1002- 1018 (19.70/17.86)	PPPQqqpfpKQPGTSGA
 1159- 1170 (26.82/10.78)	PPPR.....KLPQRSWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      31|     135|     145|      11
---------------------------------------------------------------------------
  135-  145 (16.90/ 7.76)	RLASLARDALV
  168-  178 (20.20/10.55)	RLPTCIRDKII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29697 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLMSQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
970
1170










Molecular Recognition Features






MoRF SequenceStartStop




NANANA