<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29695

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPASAPVPPPPGAAVAAAAAAAASPGYRLMPRNPRLLPIQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNATDREDSPVVALLLQQFKENVQDLIYRTKPGKQTKTGTKRKVCDDPCPVESKKTKRSGETCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQIEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLMSQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1429
PositionTail
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.07
Grand average of hydropathy-0.200
Instability index52.68
Isoelectric point9.05
Molecular weight157725.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29695
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     106.14|      18|      18|    1076|    1093|       1
---------------------------------------------------------------------------
  979-  995 (27.16/ 8.88)	PQQQPFP.KQ.....PGTSGAYP
 1040- 1062 (25.69/ 7.95)	FVPTPPPSSHgisigPGASFASP
 1072- 1088 (26.26/ 8.31)	.YTMVSPSGR.....AGNWPGSP
 1089- 1107 (27.03/ 8.79)	QVSGPSPATR....lPGMSPANP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.91|      14|      18|    1004|    1019|       2
---------------------------------------------------------------------------
 1004- 1019 (23.61/16.09)	HSTvnQSPS.MMHTQSP
 1023- 1037 (21.30/ 8.44)	HAA..SSPSgALRAPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.96|      16|      18|      13|      28|       3
---------------------------------------------------------------------------
   13-   28 (32.13/18.32)	PPGGGGGGSGGPASAP
   32-   47 (26.83/14.01)	PPGAAVAAAAAAAASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.62|      18|      20|     641|     660|       4
---------------------------------------------------------------------------
  641-  658 (32.74/14.32)	IPHQGVQIEGDGFSHAIR
  704-  721 (31.87/10.17)	CPLNGTSTREQGPSRHVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.13|      14|      19|    1250|    1268|       5
---------------------------------------------------------------------------
 1250- 1268 (16.88/26.70)	PDELQvleKFfeTRVAGPP
 1271- 1284 (22.24/13.86)	ANTLI...AF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.70|      13|      19|     188|     200|       6
---------------------------------------------------------------------------
  188-  200 (22.56/12.77)	ANLTVA..NGRVKFR
  207-  221 (21.14/11.50)	ATLTVMgdDPDVPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.43|      18|      19|     518|     536|       7
---------------------------------------------------------------------------
  519-  536 (32.19/19.85)	RL..PQYYIVVEMLEVPNKP
  538-  557 (24.24/ 8.53)	QLsyKYYFMSVNATDREDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.22|      74|     508|     260|     354|       8
---------------------------------------------------------------------------
  260-  334 (128.00/127.09)	DEKPLQDMYN.....................CLHSFCLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTI
  390-  490 (106.22/65.15)	ELKAILRGFNanenssietalpalvvpilepCGNSECLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1338|    1361|       9
---------------------------------------------------------------------------
 1337- 1360 (39.65/17.93)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1361- 1386 (34.41/14.63)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.24|      11|      19|     659|     672|      12
---------------------------------------------------------------------------
  659-  672 (15.13/17.69)	LLKippC....KGVNEET
  680-  694 (16.11/ 6.93)	LLD...CtfrlQGRNNRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|      19|     337|     349|      13
---------------------------------------------------------------------------
  337-  349 (23.09/15.52)	DENDVSKPLQIFH
  357-  369 (21.79/14.21)	DSKLVERAMKIDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.62|      16|      20|     878|     895|      14
---------------------------------------------------------------------------
  878-  895 (24.92/23.87)	CFSILPQSSTHIrlAFRN
  898-  913 (29.71/20.55)	CIDIYCRSRGVV..AIRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.13|      22|     155|     957|     978|      15
---------------------------------------------------------------------------
  957-  978 (42.61/19.57)	DNPPSPIGGDMMDSLMSQLQPP
 1115- 1136 (41.52/18.88)	DASHSPRAGTSSQTMPTNMPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29695 with Med14 domain of Kingdom Metazoa
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