<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29683

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTGRSQNAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTSAYYAAITETKVKKRHVDPFIEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHDFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGMSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPVDDPERKEAEGSSSSKLEDPALSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTANNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYNQVNQIVNNWREDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGEHQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKLSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSISHLSYRQGPIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPAYPGVLPTTVTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTTMLGTMTPLNTQGVQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRKYLVSSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQAAPPQPQPHTNIFGRY
Length2146
PositionKinase
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.07
Grand average of hydropathy-0.510
Instability index56.19
Isoelectric point6.63
Molecular weight239852.17
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP29683
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     154.04|      15|      15|    2042|    2056|       1
---------------------------------------------------------------------------
 2042- 2056 (36.31/13.59)	QQ.......QQQQQQQQQQQQQ
 2067- 2081 (31.09/10.71)	QQ.......QQQQQYHIRQQQQ
 2082- 2103 (26.74/ 8.31)	QQilrkylvSSQQQQQQQQQQQ
 2104- 2118 (36.31/13.59)	QQ.......QQQQQQQQQQQQQ
 2119- 2130 (23.58/ 6.57)	QQ.......QQQHQQQQQQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.97|      29|      29|    1745|    1773|       2
---------------------------------------------------------------------------
 1745- 1771 (42.40/18.20)	...........P..PEDEEPPAPTLLE..PEKKAPEPPKTDK
 1772- 1801 (34.96/13.64)	PG.......aaP..PSTEERKKKS.TK..GKKRSQPATKTED
 1806- 1845 (35.51/13.98)	PGrsgpygvtvP..PDLLHHPNPGSIShlSYRQGPIGLYTQN
 1849- 1874 (35.11/13.73)	PA..........ggPR.VDPYRPVRL...PMQKLPTRPA..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     566.34|     153|     162|    1388|    1549|       3
---------------------------------------------------------------------------
 1233- 1346 (125.64/65.55)	....................................................AELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKY......VLRSICQQEWVGERCLKSLCEDSNDL.....QDPVLSSaqaqrlmqliCYPH...RLLD.......NEDGenPQRQRIKR
 1388- 1549 (240.77/153.89)	EvfqqsaeTGSSSG.......STANNMPSSSKTkpVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEEL..EKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSL......VLTCLKGQDEQREGLLTSLYNQVNQIVNNWREDQYLDD..........CKPK...QLMHEALKLRLNLVG..GMFDTVQR
 1553- 1709 (199.93/112.42)	Q.......TTEWAMllleiiiSGTVDMQSNNEL..FTTVLDMLSVLINGTLAADMSSISQGSM.....EE...NKRAYMNLVKKLQKELGEHQSDSLEKVRQLLPLpkqtrdVITC.....EPQGSLIDTKGNKIAGFDSIFKKEGLQVS..........TKQKispWDLFEGLKLSAPLSW..GWFGTVR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     663|     122|     135|       4
---------------------------------------------------------------------------
  122-  135 (24.94/15.91)	GTKPLTQLAKKVPI
  786-  799 (25.11/16.08)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.39|      96|     148|     922|    1029|       7
---------------------------------------------------------------------------
  922- 1029 (149.51/137.20)	LclCivAVLRHYhaCLILNQDQMAqVFEGLCGVVKHG.......MNRSDGSSaerciLAYLYDLYTSCSHLKSKFGELFSDF..CSKVKNTI..YCNVEPSESNMRWAPEFMIDTLENP
 1077- 1183 (150.89/102.61)	L..C..AELTGY..CKSLSAEWLG.VLKALCCSSNNGtcgfndlLCNVDVSD.....LSFHDSLATFVAILIARQCLLLEDLirCAAIPSLLnaACSEQDSEPGARLTCRILLHLFKTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      13|      20|    1958|    1975|       9
---------------------------------------------------------------------------
 1958- 1971 (23.75/ 7.60)	QHTGPAGTMvPPSY
 1997- 2009 (20.17/ 9.61)	RPSGYVHQQ.APTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.11|      30|      73|     599|     634|      12
---------------------------------------------------------------------------
  599-  634 (45.68/43.98)	LFCELIRHDvFShnMYTCTLISRGDlafGAPGPRPP
  675-  704 (59.43/35.22)	LFEDMEKPD.FS..LFSPTMPCEGK...GSPSPEKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29683 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSISHLSYRQGPIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPAYPGVLPTTVTGVM
2) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
3) GAPGPRPPSPFDDPVDDPERKEAEGSSSSKLEDPALSE
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
5) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTTMLGTMTPLNTQGVQQQQQQ
1736
687
627
15
1888
1886
726
664
64
2047










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGI
2) QILRKYLVSSQQQQQ
3) QPHTNIFGRY
4) QQQQQQQQQQQQQQQQQ
1
2083
2137
2102
6
2097
2146
2118