<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29681

Description Mediator of RNA polymerase II transcription subunit 16
SequenceRKPVGAGSWGPAEPGGRGRGLRGQRPDLPSAGAVSGTMDLAYVCEWEKWPKSTHCPSVPLACAWSCRNLIAFTTDLRSDDQDLTRTIHILDTEHPWDVHSISSQHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESCLGSMVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLSRKDKFPAITHLKFLARDMSEQVLLCASSPTSSLVECWSLRKEGLPVNNIFQQISPAVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMVVFYSSATPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHALEVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHEEYTRQSAALQQVLSTRILAMKASLCRLSPCTVTRVCDYHTKLFLMAVSSTLKSLLCPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPSSEPDEALVDECCLLPSQLLVPSLDWLPVSDGLVSRLQPKQPLRLYFGRAPTLPGSATTLQLDSLARAPGQPKMDHLRRLHLGAYPTEECKACTRCGCVTMLRSPNKTTAVKQWEQRWIKNCLCGGLWRRTPPSCP
Length866
PositionTail
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.07
Grand average of hydropathy-0.007
Instability index51.53
Isoelectric point8.31
Molecular weight95444.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364149

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29681
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.99|      37|     188|     108|     156|       1
---------------------------------------------------------------------------
  118-  154 (67.08/46.61)	GSRLLSADADGQ....I............KCWSMADHLANSWESCLGSMVEGD
  248-  300 (45.92/17.12)	GGNIVVATADGSsaspVqfykvcvsvvseKCRIDTEILPSLFMRCTTDLSRKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.01|      27|     132|      47|      73|       2
---------------------------------------------------------------------------
   47-   73 (53.52/31.43)	EKWPKSTHCPSVPLACAWSCRNLIAFT
  182-  208 (48.49/27.75)	EKFSRVKFSPSLTLFGGKPMEGWIAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.25|      48|     189|     304|     377|       3
---------------------------------------------------------------------------
  322-  377 (72.05/77.50)	CASSPTSSLVEcwSLrkEGLPVNN.IFQQISPavgdKQPMILKW.R..IL..SATN.DLDRVS
  742-  796 (65.20/26.50)	CCLLPSQLLVP..SL..DWLPVSDgLVSRLQP....KQPLRLYFgRapTLpgSATTlQLDSLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.64|      17|      25|     819|     835|       8
---------------------------------------------------------------------------
  819-  835 (34.23/18.82)	ECKACTRCGCVTMLR.SP
  845-  862 (31.40/16.66)	EQRWIKNCLCGGLWRrTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29681 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RKPVGAGSWGPAEPGGRGRGLRGQRPDLPS
1
30










Molecular Recognition Features






MoRF SequenceStartStop




NANANA