<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29675

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIQNKKSQASVSDPMNALQSLTGGPGTGAAGISMPPRGPGQSLGGMSSLGAMGQSMALSGQPPPGTSGMAPHGMAVVSTAPPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLPQMHHAQHHQPPPQAQQPSVAQNQPSQLTPQSQNQPLVSQAQALPGQMLYPQQQLKFVRAPMVVQQPQVQPQVQPQVQPQVQQQAAVQTAQTTQMVAPGVQMIAEALAQGGMHVRARFPPASAMSAVQSSSIPLGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEEDDRQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAS
Length785
PositionTail
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.03
Grand average of hydropathy-0.673
Instability index86.87
Isoelectric point9.39
Molecular weight86248.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29675
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     356.86|      64|      82|     154|     235|       2
---------------------------------------------------------------------------
  152-  233 (104.48/19.38)	QLQLQQVA.LQ.QQQQQQQQQqfqqqqaalqqqqqqqqfQAQQ...........................SAM............QQQFQAVVQQ.......QQQLQQQQ...QQQQHLIKL.....HHQNQQQIQQQ
  234-  297 (109.89/20.81)	QQQLQRMAqLQlQQQQQQQQQ..................QALQ...........................A..............QPPIQQPPMQ.......QPQPPPSQ...ALPQQLPQM.....HHAQHHQPPPQ
  298-  359 (77.98/12.36)	AQQ.PSVA....QNQPSQLTP................................................................QSQNQPLVSQ.......AQALPGQMlypQQQLKFVRApmvvqQPQVQPQVQPQ
  361-  457 (64.51/ 8.79)	QPQVQQQA.AV.QTAQTTQ........................mvapgvqmiaealaqggmhvrarfppaSAMsavqsssiplggQPTAQ..VSQssltmlsSPSPGQQV...QTPQSMP..........PPPQPSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.63|      20|      22|      86|     107|       3
---------------------------------------------------------------------------
   87-  108 (35.85/24.75)	SLTGGPGTGAAGISMPPrgPGQ
  109-  128 (35.78/18.41)	SLGGMSSLGAMGQSMAL..SGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      16|      22|     471|     490|       4
---------------------------------------------------------------------------
  480-  499 (26.42/11.40)	SPSPQPSQSPVtartPQNF..S
  500-  518 (22.38/ 6.52)	VPSPGPLNTPV...nPSSVmsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     679|     696|       5
---------------------------------------------------------------------------
  679-  696 (32.84/20.96)	VARLDPKFLVNLDPSHCS
  704-  721 (32.24/20.44)	ICKLDDKDLPSVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.64|      27|      27|     560|     586|       6
---------------------------------------------------------------------------
  530-  554 (24.59/ 9.74)	LDKLKQL.......SKYIeP..LRRMinkiDK..NE
  560-  586 (49.12/27.41)	LSKMKSLLDILTDPSKRC.P..LKTL....QK..CE
  589-  616 (35.93/17.91)	LEKLKNDMAVPTPPP....PpvLPTK....QQdlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.17|      14|      22|     617|     630|       9
---------------------------------------------------------------------------
  617-  630 (23.95/14.09)	PLLDAVLA.NIRSPV
  641-  655 (22.21/12.53)	PAMTAIHGpPITAPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      26|     743|     753|      10
---------------------------------------------------------------------------
  743-  753 (23.12/14.39)	NPFLQSVHR.CM
  771-  782 (18.67/10.20)	NTWAQSIHQaCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29675 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQPQVQPQVQQQAAVQTAQTTQMVAPGVQMIAEALAQGGMHVRARFPPASAMSAVQSSSIPLGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) QNKKSQASVSDPMNALQSLTGGPGTGAAGISMPPRGPGQSLGGMSSLGAMGQSMALSGQPPPGTSGMAPHGMAVVSTAP
3) QQALQAQPPIQQPPMQQPQPPPSQALPQQLPQMHHAQHHQPPPQAQQPSVAQNQPSQLTPQSQNQPLVSQAQALP
343
70
254
535
148
328










Molecular Recognition Features






MoRF SequenceStartStop




NANANA