Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGTAPPSSAATAPSGADKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHDYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLSGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR |
Length | 244 |
Position | Head |
Organism | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.042 |
Instability index | 63.30 |
Isoelectric point | 9.78 |
Molecular weight | 26287.66 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29672 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 168.21| 41| 115| 90| 130| 1 --------------------------------------------------------------------------- 90- 130 (76.18/36.58) EHDYNKFCGKKVKEKLSN.F.L..PDLPGMIDL.....PG...SHDNSSLRSL 138- 184 (34.67/13.11) GGSFNPITG....TMLSG.FrLhtGPLPEQCRLmhiqpPKkknKHKHKQSRT. 206- 243 (57.36/25.94) EEDPDRKRKKKEKKKKKNrH.S..PDHPGM.........G...SSQASSSSSL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSP 2) FGPGKPPP 3) MENFTALF | 195 23 1 | 227 30 8 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab