<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29662

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFSNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASTASDGPVPVSPEVEQAMRQWEYNEKLAFHMFQEGLLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPSLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNESKNVSAGSPLDLLQVAPSSLPMPGGNTAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRSPAGENVDEHYPKDHEVKLEIFSPMPGESCENANPSLGRRMSLNGEKLAKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKVLSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQAAGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRSLRREGTAEDVWPASHSSKPCAKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGLKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSHSGMGLFHPSGNGGADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWKEERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTAEWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSAKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPASPISQEPERKSAELSDQGKTATEEEKKSRGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQMMHHPQSTLWGYNLMGQTQQPSFFLQNQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQPPQYPGLQQAQTMPQGYTMYGTQMPLPQPAQPQAGVVLSPSYGSRAYPAAHSSPALMERLRQMQQQPSGYIQQQAPPYLQPLTGAQRMNHQALQQSPLVGGGIDAMMTPAHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVWGREMQQPQQPPQPQPSSQPQSQQTLGLQAVQPQQPLFPRPGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2148
PositionKinase
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.07
Grand average of hydropathy-0.406
Instability index57.78
Isoelectric point7.99
Molecular weight239769.85
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29662
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     175.44|      26|      27|    2066|    2091|       1
---------------------------------------------------------------------------
 1862- 1896 (26.45/ 7.36)	QRRSGAMMQPpslhaitsqQQLI.........QMKLL.QQQ......QQQR
 1900- 1938 (25.90/ 7.04)	QAQARPFQQG...........PPgdqaalfaaQARPS.PQPpqypglQQAQ
 1942- 1963 (36.47/13.12)	Q..GYTMYGT.........QMP..........LPQP..AQP......QAGV
 2066- 2091 (55.45/24.04)	QVWGREMQQP.........QQPP.........QPQPS.SQP......QSQQ
 2093- 2117 (31.17/10.07)	..LGLQAVQP.........QQPL.........FPRPGlQQT......QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     176.12|      43|     152|     875|     921|       2
---------------------------------------------------------------------------
  875-  918 (74.34/48.83)	YTTGL..CVCIVAV..LrRYHS.............CLILNPEQTAQVFEGLCGVVKHVVNP
  936-  961 (28.37/18.46)	...................YVS.............CSHLRS.KFGDLFSSACSKVKQTI..
 1034- 1063 (46.51/23.14)	FSSEL..TAC.........................CTVLSSEWLG.VLKALCCSSNHV...
 1065- 1109 (26.89/11.37)	...GFndVLCTVDVsdL.SFHDslatfiailiarqC...........F.SLEDVVQHVALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.27|      20|     152|      79|     104|       3
---------------------------------------------------------------------------
   79-  104 (27.05/27.27)	EKLKLNTFQDtGkkkpqVNAKDNY..WL
  234-  255 (34.22/17.34)	EKLAFHMFQE.G.....LLEKHEYltWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.15|      30|     250|     554|     584|       5
---------------------------------------------------------------------------
  554-  584 (46.39/35.97)	ESISS.ASLAGSSLPVFQNVLLRFlDTQAPSL
  811-  841 (49.76/33.80)	EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.60|      28|     250|    1576|    1603|       6
---------------------------------------------------------------------------
 1576- 1603 (47.81/25.81)	LINGTLASDLSSASPGGS...EENKRAYMNL
 1830- 1860 (43.79/23.02)	LQNQALTPGGSRLDPAGSfvpTNTKQALSNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.02|      21|     250|    1719|    1749|      11
---------------------------------------------------------------------------
 1721- 1741 (38.43/38.22)	PKPRSYYLEPLPLPPEEEEEE
 1750- 1770 (33.60/ 9.37)	PERKSAELSDQGKTATEEEKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.61|      24|     155|    1307|    1338|      12
---------------------------------------------------------------------------
 1278- 1301 (40.94/21.88)	VLSNMQAQKLLQ.LICYPHGLKECT
 1314- 1338 (37.67/40.75)	ILQNLEQWTLRQsWLELQLMIKQCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.13|      18|      19|    2008|    2025|      14
---------------------------------------------------------------------------
 2008- 2025 (31.57/13.01)	PLTGAQRMNHQALQQSPL
 2029- 2046 (29.23/11.52)	GIDAMMTPAHPSLPSVPL
 2050- 2064 (26.34/ 9.69)	PMRPRQ...PQVRQQQRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29662 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQPPQYPGLQQAQTMPQGYTMYGTQMPLPQPAQPQAGVVLSPSYGSRAYPAAHSSPALMERLRQMQQQPSGYIQQQAPPYLQPLTGAQRMNHQALQQSPLVGGGIDAMMTPAHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVWGREMQQPQQPPQPQPSSQPQSQQTLGLQAVQPQQPLFPRPGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2) PSFFLQNQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
3) RSYYLEPLPLPPEEEEEEPASPISQEPERKSAELSDQGKTATEEEKKSRGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQMMHHPQSTLWGYNL
1888
1826
1724
2148
1877
1819










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFG
2) YLEPL
1
1727
5
1731