Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK |
Length | 57 |
Position | Middle |
Organism | Homo sapiens (Human) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo. |
Aromaticity | 0.09 |
Grand average of hydropathy | -1.061 |
Instability index | 53.18 |
Isoelectric point | 8.98 |
Molecular weight | 6985.86 |
Publications | PubMed=16625196 PubMed=18691976 PubMed=21269460 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29651 No repeats found No repeats found |
Disease | osteosarcoma PMID:24969180 |
MoRF Sequence | Start | Stop |
1) AQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK 2) MLELLQYEHFRKE | 17 1 | 57 13 |
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