<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29644

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRFVWQGPTSAPILFPVTEEDPILCSFSRCLKADILSVWRRCQQQGRRELWLFWWGDDPNFADLIHNELAAEDDGLWENGLSYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCAFTFFLHGESNVCTSVEINQHQPVYHLTEEHLTLAQQASSPFQVILSPFGLNGTLTGQSFKMSDPPTQKLIEEWNQFYPISPSAKENVSEDKVEDMDWEDESLASVEVLVGGVRMVYPACLVLVPQSDIPVVTPVGSSHCTAVYSGGHQVPASQREPAMSLVTLTPPTSPEEAQTVDSHSAQKWVKMPSSSDAFSVDRTSHHGGKIPRRLASQMVERVWQECNINRAQNKRKFPAATNGTCEEEPSEKLGTWDFVESSQRSYCSCSRYKLVKQRTANNTGQAQSAGQPSQPPTKHKTGGEKPEKGDKQQKRPQTPFHHRCLASDEASIDTEATAGQRLALRSQDGARFPSIRSADVSAIQKAPQLHSGGVSTGPSEQANSPQPPPLSPHPCERSEESGEGMKNPSTPNSQHFYQPQPEACLVGVKGSSEEQGGPEALNQHFQSHQPNPHPGTSAYSEPPEPTVYVGAAINLEDDGSHAPWRLFNLPRRKEAELPTPLLPGDKLREEAAASQDNLVSVTEVMSTSKWPLKVSEERVQMYRARRNQHLAAAVTDGDHEPEVDPYAFEEGDVKFTFSNKKDKSGGEREPGKKHKVSGFSNSRRLLVEREKYLKLVFVCSDPQRAAPHNRVASTSLIHETDLVVSINDLDNLFNSDEDELAPGSRRPVNGTDGIFGNKEPKSSILDPVPCMCSDHLIQMFPTPPSLEQHIMGYSPMNMCSKEYCTMEPGTGMTTVEGPSTLGGHFKIEVEESFCSPKPSEIKDYSFVYKPELCQPFVGCSMFAPLKTLPSQCLPPIKVPEDCIYRPSWTMGRDMLNPVPVMTYLNKDSNIPSVGSTMDQEYTPQTQTPFMINSAPPSNSGGTGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSIKYENSDLCSPAASTPSTCRPLNSVEPATVPSIPEAHSLYVTLILSETVMNLFKDCNFDSCCICECNMNIKGADAGVYLSDPVSEAQKQCGCGFSAVVNRRYGNGSGLFLEDELDIIGRGTDISREAEKRFEELRLSSLERNGVGRSDHISDELILLMQDQCTNPFSPISVLEHDAVTRGPGGAPIPPCVRVEERDYRSDCYMAMEHGRQFMDNMSGGKVDEALVKSTCLHNWAKQNAVDVSALCSQDVLRVLMSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDIGYLVVCPDNEALLSGAKTFFRDLTAVYESCRLGQHRPISKGYADGIVLVGGSGAKTPVDQPVSDWFLKAASSNSDTFAKLKLYAQVCRHNLAPYLASQALDSSLLTQPSPTPSSNQSSSTQLSNSTSSTASQQGSVNAAGSTVPSNSGPGNSSASSNNLVTSSGQTGSTIPAKPGSFPPFGSIGSQGQGGGPQSGQLGQQAGTQNTGVSGDNSSSQAQGPTEPPESTLEREKVGVPTDGESHAVTYPPAIVVYIVDPFSYEEADRGAGPVPAQSSVWTLGLLRCYLEMLQSLPPHIRNSVSVQIIPCQYLLQPVRGEDRHIYSQHLKSLAFSVFAQCRRPLPTSTNVKSLTGFGPGLAIDTALKSPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLATCTDLYGELLETCIINIDVPHRARRKKGSVRRLGLQKLWDWCLGLVQMTSLPWRVVIGRLGRIGHGELKDWSILLNRRNLQSLSRRLKDMCRMCGISASDTPSILSVCLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAIVQVASSNYTNIDTNIDILNPTTDGSDAIGILALLDQENDLVDPDIINISPTTSPVHSPGSHYHHGGDGSKGQSTDRMESHEEVPNLLQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQMYNFIMNML
Length2179
PositionMiddle
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.07
Grand average of hydropathy-0.421
Instability index56.90
Isoelectric point5.69
Molecular weight239118.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29644
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     174.09|      32|      32|     529|     560|       1
---------------------------------------------------------------------------
  529-  560 (60.18/27.31)	SGGV....STGPSEQANSPQPPPLSPHPCERS..........EESG
  562-  594 (44.13/17.85)	..GM.knpSTPNSQHFYQPQPEACLVGVKGSS..........EEQG
  605-  637 (35.69/12.87)	SHQP....NPHPGTSAYSEPPEP.........tvyvgaainlEDDG
  638-  668 (34.09/11.92)	SHAPwrlfNLPRRKEAELPTP..LLPGDKLRE..........E...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.98|      24|      32|    1108|    1135|       2
---------------------------------------------------------------------------
 1108- 1135 (38.66/36.60)	KDCnfdSCCICECnMNIK.GADAGVYLSD
 1142- 1166 (40.32/23.81)	KQC...GCGFSAV.VNRRyGNGSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     162.02|      30|      32|    1013|    1042|       3
---------------------------------------------------------------------------
  946-  964 (25.21/ 6.74)	...........LPSQCLPPIKVPEDCIYR.P
  977- 1006 (40.44/15.31)	PvMTYLNKDSNIPSVGSTMDQEYTPQT.QTP
 1013- 1042 (56.09/24.12)	P.PSNSGGTGILPSPATPRFSAPTPRTPRTP
 1048- 1073 (40.28/15.23)	P.SSVQGSIKYENSD....LCSPAASTPSTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.46|      11|      32|     778|     788|       4
---------------------------------------------------------------------------
  778-  788 (21.67/14.16)	SDPQRAAPHNR
  813-  823 (19.80/12.11)	SDEDELAPGSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.09|      30|      34|     289|     322|       5
---------------------------------------------------------------------------
  291-  322 (49.72/33.69)	IPVVTPVGSSHCTAVYSGGHQ....VPASQrePAMS
  324-  357 (46.37/20.11)	VTLTPPTSPEEAQTVDSHSAQkwvkMPSSS..DAFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.78|      22|      24|    1517|    1538|       6
---------------------------------------------------------------------------
 1517- 1538 (37.93/21.25)	SNS..TSSTASQ.QGSVNAA...GSTVP
 1539- 1565 (25.86/11.48)	SNSgpGNSSASS.NNLVTSSgqtGSTIP
 1572- 1589 (21.00/ 7.55)	P.P..FGSIGSQgQGGGPQS...G....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.60|      29|      38|      21|      57|       7
---------------------------------------------------------------------------
   21-   52 (47.25/40.70)	CL.ADLTGIkWKRFVWQGPTSAPILFpvTEEDP
   60-   89 (56.35/25.95)	CLkADILSV.WRRCQQQGRRELWLFW..WGDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.76|      21|      38|     861|     881|       8
---------------------------------------------------------------------------
  838-  851 (21.63/ 8.94)	.................PKS...SILDPVP.CMCS
  852-  878 (34.90/19.95)	DHL........iqmfptPPSLEQHIMGYSPMNMCS
  879-  913 (25.23/11.93)	KEYctmepgtgmttvegPSTLGGHFKIEVEESFCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.89|      10|      27|    1171|    1180|       9
---------------------------------------------------------------------------
 1171- 1180 (18.29/11.07)	IGRGTDISRE
 1198- 1207 (18.60/11.39)	VGRSDHISDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.74|      29|     339|     404|     433|      11
---------------------------------------------------------------------------
  404-  433 (50.11/41.50)	EEEPSEKLGTWDFvESSQRSYCSCSRY.KLV
  745-  774 (45.63/32.05)	EREPGKKHKVSGF.SNSRRLLVEREKYlKLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     252.77|      77|     619|    1425|    1512|      13
---------------------------------------------------------------------------
 1425- 1512 (119.60/103.69)	RLGQHRPISKGYADGIVLvgGSGAKTPVDQPVSDWFLKA...ASSNSDTFAKLKLYAQVcrhnlapylASQALDSSLLTQPSPTPSSNQSS
 2053- 2132 (133.17/87.77)	RMESHEEVPNLLQQPLAL..GYFVSTAKAGPLPDWFWSAcpqAQNQCPLFLKASLHLHV.........SSVQSDELLHSKHSHPLDSNQTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.21|      31|     613|    1295|    1360|      14
---------------------------------------------------------------------------
  122-  160 (45.62/11.38)	AIHNllERCLmnRSFVRIG..KW..FVK.....PYEKDEKPinksEHL
 1317- 1356 (46.59/83.84)	AIQK..KRTV..RSWGVQGplTWqqFHKmagrgSYGTDESP....EPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.08|      11|      31|    1245|    1255|      15
---------------------------------------------------------------------------
 1245- 1255 (20.60/14.97)	RVEERDYRSDC
 1273- 1283 (18.48/12.50)	KVDEALVKSTC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29644 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIINISPTTSPVHSPGSHYHHGGDGSKGQSTDRMESHEEV
2) DSSLLTQPSPTPSSNQSSSTQLSNSTSSTASQQGSVNAAGSTVPSNSGPGNSSASSNNLVTSSGQTGSTIPAKPGSFPPFGSIGSQGQGGGPQSGQLGQQAGTQNTGVSGDNSSSQAQGPTEPPESTLEREKVGVPTDGES
3) GSHAPWRLFNLPRRKEAELPTPLLPGDKLREEAAASQDNLVS
4) NINRAQNKRKFPAATNGTCEEEPSEKLGTWD
5) PSVGSTMDQEYTPQTQTPFMINSAPPSNSGGTGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSI
6) QREPAMSLVTLTPPTSPEEAQTVDSHSAQKW
7) QRTANNTGQAQSAGQPSQPPTKHKTGGEKPEKGDKQQKRPQTPFHHRCLASDEASIDTEATAGQRLALRSQDGARFPSIRSADVSAIQKAPQLHSGGVSTGPSEQANSPQPPPLSPHPCERSEESGEGMKNPSTPNSQHFYQPQPEACLVGVKGSSEEQGGPEALNQHFQSHQPNPHPGTSAYSEPPEPTVYVGAAINL
2021
1495
637
385
989
316
435
2060
1635
678
415
1055
346
633










Molecular Recognition Features






MoRF SequenceStartStop




NANANA