<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29633

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFLEDPLPTTDVFAGCQIPYPKREFLNEDEPEEKTEKNQTQQHQQTTGQAQAQNQQQTAAQQAPSQQSSAQTNGTAGATGATTAALQHGQDQGPPNKKPRIGPSGASSGTGVLQSDYQHSGSRLGYQSNVQGSTQPQSTMGYSSSTQQSSQYSHQTHRY
Length492
PositionKinase
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.09
Grand average of hydropathy-0.705
Instability index45.61
Isoelectric point8.66
Molecular weight55925.57
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29633
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.94|      20|      35|     422|     456|       1
---------------------------------------------------------------------------
  436-  456 (33.56/31.84)	PS...GASSGTGvLQSDYQHSGSR
  469-  491 (32.38/ 7.16)	PQstmGYSSSTQ.QSSQYSHQTHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.27|      25|      40|     102|     129|       2
---------------------------------------------------------------------------
  102-  129 (44.55/31.31)	HDLWhiiKFHRASK.ANKKPM.QLP.RGMVK
  143-  170 (34.73/17.54)	HANW...VLHRDLKpANILVMgEGPeRGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.75|      28|      30|     372|     400|       8
---------------------------------------------------------------------------
  366-  398 (38.13/24.21)	EKteknQTQQHQQTTGqAQAQNQQQTAAQQAPS
  399-  429 (43.62/23.70)	QQ.ssaQTNGTAGATG.ATTAALQHGQDQGPPN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29633 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKTEKNQTQQHQQTTGQAQAQNQQQTAAQQAPSQQSSAQTNGTAGATGATTAALQHGQDQGPPNKKPRIGPSGASSGTGVLQSDYQHSGSRLGYQSNVQGSTQPQSTMGYSSSTQQSSQYSHQTHRY
351
492










Molecular Recognition Features






MoRF SequenceStartStop




1) GPPNKKPRIGPS
2) LGYQS
426
457
437
461