Description | Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MSSCFVPNGASLEDCHSNLFCLADLTGIKWRRFVWQGPTSSPILFPVTEEDPILCSFSRCLAADVLSVWRRHHTPGRRELWLFWWGDDPSFAELIHNELLSEEDGEWESGLSYECRTLLFKAIHNLLERCLMNRGFVRIGKWFVKPYQKEEKTINKSEHLSCAFNFFVHGDSNVCTSVEIAQHQPLQRLSEEHLSLAQQSSSPLQVILSPYGLNGTLTGQAFKMSDHPTQKLIEEWRQFYPISPNPKEVQEEKLEDADWEDDSLAAVEVLVAGVRMVYPSCLVLLPLSDLPTVVPQGSANASGSLCGAQQGQAANRDPAMSSVTLTPPTSPEEAQTEYQPAQKWLKLSSASDGYSSNNTLHGGKIPRRMASQMVESVWQEYNLNHTGNKNKFTSLTNGTCEEETEKTGLWDFVEPAHRLHCNCSRHKNSKQRSSSTSGHPPSSGQPVLPAPKHKLGEKLEKGEKQQKRPQTPFHHRNSVSEEQSLEPQTQRLCLRSQEEGSYPSLHHVDTVQSKAPTLHAHGPPADLVGSPPPPPLSPHPCDHVEVDMTPGGMKSSSTPIHQPFYPPSVEPCQMPPKGSSEESQMENMPMPLPFPSTYNETLEPTIFVGSAISPSDDSTHNPWKYFLLPQKKPSNFLTPQLPLDKMREDSAGGGGSESGVVSVTELMSGSSHPLKVSQELVKTYTQRRNSHLASTSGDEEPSEEPDPYAFVEGDEEFSFTEKKDKSGAEKDGNKKHKVDEGTGTSADALIQKMSLNLFCGVDGQCPTGSKPSASTSLIHENDLAVSYSDLDKIFNSDEDELAPGSKRAGVGTDDKFGSKDTKPTALDPLSCISSVDLHTMFPTPPSLEQQGYSPMNSGSKDSLEAGAGLTLLDGSQLNNHFKMEVEEGFCSPKPSEIKDFSFVYKPEMCQSFIGCSMYAPLKTLPSQCLLPVKLPEDCVYTASWTLGKMDLIPPVSNTSLLTKDSNVPSVEPDYSQTYTPQTHPPFMSSSAPPSNSGAGILPSPATPRFSVPTPRTPRTPRTPRGPSSVQGSLKYDSSDLYSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCVCVCNMNIRGADVGVYLKDNGEAQYICTCGFSAVTNRRFGQSAGLFLEDELDVVGRGSDAARDTERCFEELRASTSHKASSLKEKPPDELILLLQDQCTNPFAAMAGVEYPKPTSAPSSFLRVEERDCYNDCYMALEHGRQFMDNMSGGKVDETLVKSTCLHQWPKRKSDMSKLYSVDVLRVLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDVGYVVICPDNESLLRGAKTFFKDLSAMYEACQLGQHRPICKSHPEGILKVGTKEGRNMTEQPLSDWFVKMAAREGNNEAFNKLKLFAQVCCYDLAPYLSEQSLDSSLLTQRNPTTAATPSFQTSSSSSTSSGLQSTNTTGSNTSSAQPAQPAQVNSTPPSSSSGSQTIGGMTSAKPSSFSPFGTAGLQGGVSQNGPQPNSQGTGGLAENGSSAYPSQGPTESPERSPTCTHVIICLIFNSTMERDKVGKPTDGESHAVSYPPAIVVYIVDPFSYEDADREVHSSTYTMGLLRCYMEMLHILPACIRNSVSVQIVPCQYLLQPVHSAGRHVYSQHLKSLAFSVFTQCRRPLPNSTNFKALTGFGPGLAIDMALKNPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDQHGELLETCIISIDVPNRARRKKGSARRLGLQKLWEWCLGLVQLTSLPWRVVIGRLGRMGHGEVSDWSILLSRRNLQSLSKRLKETCRMCGISAADTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAMVQVNTNTSEPIDIDTFNQINPDGSEGMNIFELFEQDMDPDFINILPNSPTTSPVHSPGPQGGDGSKGQSTDRMESHEEALNILQQPMALGYFVSTAKAGPLPDWFWSACPQAKNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLTQMYNFIMNML |
Length | 2152 |
Position | Middle |
Organism | Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.436 |
Instability index | 57.78 |
Isoelectric point | 5.58 |
Molecular weight | 236513.81 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29632 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 128.66| 31| 36| 504| 539| 1 --------------------------------------------------------------------------- 473- 503 (35.62/10.87) FHHRNSVseeQSLEPQTQRLCLRSQEEGSYP... 505- 535 (59.41/37.77) LHHVDTV...QSKAPTLHAHGPPADLVGSPPPPP 545- 567 (33.63/ 9.53) .....EV...DMTPGGMKSSSTP...IHQPFYPP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 99.13| 28| 36| 36| 69| 2 --------------------------------------------------------------------------- 21- 54 (43.67/18.35) CLA.DLTGIkWrrfvwQGPTSSPI.LFPVTEEDPIL 60- 89 (29.96/24.68) CLAaDVLSV.W..rrhHTPGRRELwLF.WWGDDP.. 1579- 1596 (25.50/ 7.96) ................QGPTESPE.RSP.TCTHVII --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.23| 31| 36| 1506| 1539| 3 --------------------------------------------------------------------------- 1509- 1539 (58.43/36.58) QPAQPA..QVNSTPPSSSSGSQTIGGM....TSAKPS 1542- 1578 (42.80/17.78) SPFGTAglQGGVSQNGPQPNSQGTGGLaengSSAYPS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.28| 13| 14| 574| 586| 5 --------------------------------------------------------------------------- 574- 586 (24.10/12.38) MP.PKGSSEESQME 590- 603 (20.18/ 8.84) MPlPFPSTYNETLE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 116.57| 34| 40| 1017| 1050| 6 --------------------------------------------------------------------------- 1017- 1050 (62.49/34.04) PRT.PRTPRGPS.SVQGSLKYDSSDLYSPASTPSTC 1058- 1093 (54.08/28.39) PATvPSIPEAHSlYVTLILSESVMNLFKDCNFDSCC --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.68| 13| 35| 849| 861| 7 --------------------------------------------------------------------------- 849- 861 (25.59/13.36) QQGY.SPMNSGSKD 886- 899 (20.09/ 8.69) EEGFcSPKPSEIKD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 370.09| 111| 263| 1678| 1793| 8 --------------------------------------------------------------------------- 1678- 1793 (188.56/117.37) CQYLLQPVHSAGRHVYSQHLKSLAFSVFTQCrRPlPNSTNFKALTGFGPGLAIDMALKNPERPECLRLYTP.PFILAPVKDKQTELGETFGEAsqkYNVL....FVGYCLSHDQ.....RWLLASC 1943- 2063 (181.53/99.61) CTHILVFPTSAMVQVNTNTSEPIDIDTFNQI.NP.DGSEGMNIFELFEQDMDPDFINILPNSPTTSPVHSPgPQGGDGSKGQSTDRMESHEEA...LNILqqpmALGYFVSTAKagplpDWFWSAC --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.17| 18| 35| 415| 432| 9 --------------------------------------------------------------------------- 415- 432 (34.25/24.27) PAHRLHCNCSRHKNSKQR 451- 468 (29.91/20.06) PKHKLGEKLEKGEKQQKR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 100.83| 31| 33| 295| 325| 12 --------------------------------------------------------------------------- 295- 325 (53.06/26.41) PQGSANASGSLCGAQQ..GQAANRDPAMSSVTL 328- 360 (47.77/23.07) PTSPEEAQTEYQPAQKwlKLSSASDGYSSNNTL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.27| 23| 38| 684| 706| 14 --------------------------------------------------------------------------- 684- 706 (40.36/20.10) YTQRRNSHLASTSG......DEEPSEEPD 719- 747 (31.92/14.44) FTEKKDKSGAEKDGnkkhkvDEGTGTSAD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.10| 19| 38| 1163| 1181| 17 --------------------------------------------------------------------------- 1163- 1181 (31.68/16.50) ELRASTSHKASSLKEKPPD 1202- 1220 (33.42/17.85) EYPKPTSAPSSFLRVEERD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 251.86| 82| 429| 1417| 1506| 20 --------------------------------------------------------------------------- 1417- 1506 (126.41/101.42) GR..NMTEQPLSDWFVKMAARegNNEAFNK.LKLFAQVCCYDLApylSEQSLDSSLLTQRNP..TTAATPSfqtSSSSSTSSGLQST.NTTGSNTS 1849- 1936 (125.45/78.65) GRlgRMGHGEVSDWSILLSRR..NLQSLSKrLKETCRMCGISAA...DTPSILSACLVAMEPqgSFVIMPD...SVSTGSVFGRSTTlNMQTSQLS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DPYAFVEGDE 2) KLGEKL 3) PWKYFLL | 706 454 622 | 715 459 628 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab