<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29626

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEMSGADSDWRSPQFRQKVVAQIEEAIRKAGTSNTTHKSGTDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKALGGSDPMNALNTLTGVGGGPGAIGMGPRPAGAPVGGMGAMGPMQIGQHAMAGVAGNPQAIGGPGPMPMQHQVRPGHTPCRQSECCVXHISIDPVVQQQQQQVQAQTQPVQMPPHSQQQQQQQQQSGMVPQSLTGQIPSQHVSLNQQQQQQRLQAFQVRQSCRFGSVTATESQPDSRCISAFLHHSFTQCCHLKDWTDTLTSEKAANQIFKIKQEVCNENPTRGCDQSAVPAPVVSVLPPSACMAALQQQQQQAAQQAQQAAAQAQLNAAAAAATVPGQVRTPPQTQVHQLQSDKRQEIVEQVSEYTSLQQKQLVRPGMQIPARLPRAPLNPIPPQNATTAAAGVVGVQAMTPQMSSPSPVQVPTPQSMPPPPQPSPQPPTSQPNSASSGPTPSPGGFQPSPSPQPSPSPANSRTPQNYGVPSPGPLSTPVNPNSVMSPAGPTSLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPSTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVATNKQYLCQPLLDAVMANIRSPVFNHSLYRSFAPAMSAIHGPPIMGPNISGRKRKHEEDERQTIPNILQGEVARLDVKFLVNLDPSYCSNNGTVHLICKLDDKNLPSVPPLQLSVPADYPDQSPHWADDGEQYGANSFLQTVHRNMTSKLLQLPDKHSVTELLNTWARSVQQACLSA
Length778
PositionTail
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.03
Grand average of hydropathy-0.586
Instability index72.80
Isoelectric point8.94
Molecular weight84182.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29626
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     246.78|      28|      28|     426|     453|       1
---------------------------------------------------------------------------
  172-  190 (32.14/ 8.38)	QQQQQV..........QAQ...........T..QPVQM.P.PHS
  330-  358 (33.96/ 9.33)	QQAQQA..........AAQ.aqLNAAAAAAT..VPGQV.R.TPP
  384-  409 (35.79/10.29)	QQKQLV..........RPG...MQIPA..RLP.RAPLN.P.IPP
  410-  447 (42.71/13.91)	QNATTAaagvvgvqamTPQ...MSSPSPVQVP.TPQSM.P.PPP
  448-  478 (35.80/10.30)	QPSPQP.........pTSQ...PNSASSGPTP.SPGGFqPsPSP
  479-  514 (30.07/ 7.30)	QPSPSP......ansrTPQnygVPSPGPLSTPvNPNSV.M.SPA
  578-  600 (36.32/10.57)	QKCEIA..........LEK...L..KNDMAVP.TP....P.PPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.37|      19|      22|      90|     108|       2
---------------------------------------------------------------------------
   90-  108 (39.92/19.10)	GVGG.GPGAIGMGP..RP..AGAP
  111-  132 (25.22/ 9.20)	GMGAmGPMQIGQHA..MAgvAGNP
  133-  153 (32.23/13.92)	QAIG.GPGPMPMQHqvRP..GHTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.82|      21|      28|     191|     216|       3
---------------------------------------------------------------------------
  191-  206 (26.53/17.41)	........QQQQQQQQQSGMVPQS
  212-  235 (35.10/12.78)	PSQHVslnQQQQQQRLQAFQVRQS
  314-  328 (22.19/ 6.25)	PSACM...AALQQQQQQA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.27|      25|     102|     551|     577|       4
---------------------------------------------------------------------------
  551-  575 (42.25/18.30)	RKKDLSKMKSLLNILTDPSTRCPLK
  655-  679 (35.02/13.37)	RKHEEDERQTIPNILQGEVARLDVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29626 with Med15 domain of Kingdom Metazoa
Unable to open file!