<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29623

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVHVGGMIVSGPQAPPLGAPGTPGVRLSMLIEFLLQRTYQEITTLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLAREALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIRIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKTSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSILDDIEKTINDDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTDVLHLSNSASHPIGNLSKHRLFIKLTRLPQYYIIVEMLDVPSSPTALRYKYSFLSVSQLEGDDGPMCAQLLQHFKPNLEHLVQDSTTGRGAQPGTKRKIVGDQGEPEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAEMSNMEIPNQGVQVEGDGSSHAIRLIKIPPCKGVGEETRRALARSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNAISQLYQCVLTFSRALPEMPSHLSTFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPQVMQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQPQPQPQTMRGGPGGVYPPLTSPPPNYYANVTPSPSMMPTPSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGVLDPSSPYPIVSPSNRSQWPGSPQVSGPSPGARIHGMSPGNPSLNSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCHVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLTIVNSNEPGVIMFKTEVLKCRVALNPNNYQTLQLKVTPENTGPWSQEELQVLERFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRIPVPQEPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHDLMASLTLPPGTRQ
Length1435
PositionTail
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.06
Grand average of hydropathy-0.192
Instability index51.42
Isoelectric point8.75
Molecular weight158963.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29623
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     161.58|      27|      27|     996|    1022|       1
---------------------------------------------------------------------------
  973- 1011 (40.52/19.22)	SPVGVDVMDSLmnqlqpqpqpqtM..........RGGPGGVYPPLTSPP
 1012- 1047 (32.38/13.62)	PNYYANVTPSP..........smMptpspgnihaSGSPSG...ALRAPS
 1048- 1079 (29.81/11.86)	P..FGP.TPSP..sslgiamgqtS..........FASPHGVLDP.SSP.
 1080- 1101 (33.93/14.69)	...YPIVSPSN............R..........SQWPGS..PQVSGPS
 1123- 1141 (24.95/ 8.52)	PN..............................spRAGSSSQVMPTSMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.24|      50|     280|     863|     949|       2
---------------------------------------------------------------------------
  770-  827 (76.82/63.44)	FSrALPEMPSHLS.TFSE...VRLY.NYRKLVL....CYGTTKGSSVTiqwnsstQRFHLALGTVGP
  891-  949 (68.42/51.25)	FS.ILPQSPTHIRlAFRNmycIDIYcRSRGVVAirdgAYSLFDNTKIV.......EGFYPAPGLKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.06|      20|     154|     282|     302|       8
---------------------------------------------------------------------------
  282-  302 (33.51/23.16)	CLHSFCLSLQLEvLHSQTL..ML
  433-  454 (35.55/20.22)	CGRSECLHIFVD.LHSGMFqpML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.65|      36|     154|    1173|    1214|      16
---------------------------------------------------------------------------
 1173- 1214 (60.09/42.92)	PCHVPGLAGSYLCSPLERFLgsvimrRHLQRI.IQQEANLTIV
 1330- 1366 (58.56/30.72)	PIAPPGTIAVVLKSKMLFFL......QLTQRIpVPQEPVSIIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29623 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVQDSTTGRGAQPGTKRKIVGDQGEPEPKKPKRSGE
2) NQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQPQPQPQTMRGGPGGVYPPLTSPPPNYYANVTPSPSMMPTPSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGVLDPSSPYPIVSPSNRSQWPGSPQVSGPSPGARIHGMSPGNPSLNSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWA
585
957
620
1151










Molecular Recognition Features






MoRF SequenceStartStop




NANANA