<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29622

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVHVGGMIVSGPQAPPLGAPGTPGVRLSMLIEFLLQRTYQEITTLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLAREALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIRIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKTSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSILDDIEKTINDDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTDVLHLSNSASHPIGNLSKHRLFIKLTRLPQYYIIVEMLDVPSSPTALRYKYSFLSVSQLEGDDGPMCAQLLQHFKPNLEHLVQDSTTGRGAQPGTKRKIVGDQGEPEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAEMSNMEIPNQGVQVEGDGSSHAIRLIKIPPCKGVGEETRRALARSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHTSTRHVYLTYENPLSEPVGGRKVVEMFLNDWNAISQLYQCVLTFSRALPEMPSHLSTFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPQVMQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQPQPQPQTMRGGPGGVYPPLTSPPPNYYANVTPSPSMMPTPSPGVLDPSSPYPIVSPSNRSQWPGSPQVSGPSPGARIHGMSPGNPSLNSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCHVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLTIVNSNEPGVIMFKTEVLKCRVALNPNNYQTLQLKVTPENTGPWSQEELQVLERFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRIPVPQEPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHDLMASLTLPPGTRQ
Length1390
PositionTail
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.06
Grand average of hydropathy-0.187
Instability index50.05
Isoelectric point8.71
Molecular weight154607.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP29622
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     613.85|     195|     231|     667|     897|       1
---------------------------------------------------------------------------
  670-  896 (295.30/222.44)	RL.......IKIpPCKGVGEETRRALARSLLDCTFRLQGRNNRTWVAELVlaNCPLNSTHTSTRHVYLTYENPLSePVgGRKVVEMFLNDWNAISQ.....................LYQCVLTFSRALP.EMPSHLSTFSEvrlynyrklvlcYGTTKGSSVTiQWNSSTQrfhlalgTVGPNSGcSNCH.....NIILHqlQEMFNKN.PQVMQLLQVLSDTQAPlnaINKLPTVPMLGL..TQRTNTAYQCFsILPQ.SPTH
  898- 1130 (318.55/167.15)	RLafrnmycIDI.YCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFL..NMFVDSNQDARRRSVNEDDNPPS.PV.GVDVMDSLMNQLQPQPQpqtmrggpggvyppltspppnYYANVTPSPSMMPtPSPGVLDPSSP............YPIVSPSNRS.QWPGSPQ.......VSGPSPG.ARIHgmspgNPSLN..SPIPDPNsPRAGSSSQVMPTSMPP...PRKLPQRPWAASipTILTHNALHVL.LLPSpTPCH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     250.03|      97|     961|     185|     312|       2
---------------------------------------------------------------------------
  131-  248 (150.82/110.76)	LVHARL..............PSFAIPFAIDVLTTGSYprlptcirdkiippdpITKAEKQTTLNQ............................................................................................................................................................................................................lnqilRHRLV..TTDLPPQ...LANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLK.....LDILVEDKETGD
  264-  312 (23.25/64.86)	LVQARLcadekplqdmynclHSFCLSLQLEVLHSQTL................MLIRERWGDLVQ.........................................................................................................................................................................................................................................................................................
  522-  593 (75.96/43.15)	.................................................................eeryvpakyltlsvwnqqvlgrktgtasvhkvtiridesdgskplqishepplpacdsklmeramkidhlsvekllidsvharshqklqelkailktsnpsdnsfietalptlvipilepcgrseclhifvdlhsgmfqpmlygldqsilddiektinddmkriiswlqqlkfwlgeqrcrqsvkhlptvctdvlhlsnsashpignlsKHRLFikLTRLPQYyiiVEMLDVPSSPTALRYKYSFLSVSQLEGDDGPMCAQLLQhfkpnLEHLVQDSTTGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.67|      56|    1256|      23|      81|       4
---------------------------------------------------------------------------
   23-   81 (90.41/64.22)	PQAPPLGAPGTPGVRLSMLIEFLLQRTyQEITTLAE....LLPRKTDMERKieIVQFASRTRQ
 1281- 1340 (96.26/57.93)	PSAPPIAPPGTIAVVLKSKMLFFLQLT.QRIPVPQEpvsiIVPIVYDMATG..LTQQADIPRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29622 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVQDSTTGRGAQPGTKRKIVGDQGEPEPKKPKRSGE
2) NQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQPQPQPQTMRGGPGGVYPPLTSPPPNYYANVTPSPSMMPTPSPGVLDPSSPYPIVSPSNRSQWPGSPQVSGPSPGARIHGMSPGNPSLNSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWA
585
953
620
1106










Molecular Recognition Features






MoRF SequenceStartStop




NANANA