<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29615

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRYSTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPSQGCSSPLPANPPDVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGPGTGGHPAHGILTQQSNALPSTPTSQPAGGNQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSSLPMPGGNTAFTQQVRAKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDAGSSVKMEDTGLSESMEIDHNSSANFDEMFSPPMHCETKGSPSPEKPVTDQDSKPNCKDKGMDPAFPQLYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETASAYTGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPMFMMEAIANPSANNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSDKASVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHTAGLDDISEGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSNNPSGNGAAVQGGSASNNNSTTSKMKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPVSQEPEKMIEAVKTEKNVATVPPESNKKSKSKKKKTPSNKTEDYNRTPGPAYTSMAPELMQNPTYARTMPYNPQNVYTQSQPLPPGGPGLDAPYRQPTRNQIPKMMPARTNYPTMMPGMPGSMPGIMGPDKPYQMTFKPHATMPQAPNLRQQLQHQNPNALGQIRQMPPNQQYTSMQTSQAIPQGYTTYGSHMGMQQHPSQSGSIVPHSYGNQNFPGAHPGANPAVVDPLRQQRPSGYLLQQAPGYPQSMQNTQRFPHQQLQQNPIMPSHLGQMGQGVHPGLSRPNQIMRVCHLYEHIRGKKHNLDMLTCLNLHLLRLNPVLFPQPKQAQQHQQQQQQQQQQQQQVQPQQVPPQQQVPQQQQPQVTAVPPPGQAPNQGLSMQPLPPQQPMFPRAGMQQTQQQQQTAALVRQLQQQLSSTQPSQGTNSYY
Length2166
PositionKinase
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.07
Grand average of hydropathy-0.495
Instability index55.05
Isoelectric point6.94
Molecular weight242564.15
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29615
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.55|      15|      15|    2079|    2093|       1
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 2079- 2093 (31.24/12.09)	QQQQVQPQQVPPQQQ
 2096- 2110 (22.32/ 6.31)	QQQQPQVTAVPPPGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.05|      12|      15|     860|     871|       2
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  860-  871 (23.40/15.36)	IQFIFDLM.EYSL
  877-  889 (14.65/ 6.57)	IDFAIQLLnELSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.36|      38|      47|     912|     950|       3
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  912-  950 (62.45/45.27)	CIVAVLRR.YHSCLILNpEQTAQVFDGLRIVVKS....GVNPAD
  957-  999 (60.91/38.73)	CILAYLYDlYTSCSHLK.NKFGEIFSEFCSKVKNsiycNIDPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1647|    1661|       4
---------------------------------------------------------------------------
 1647- 1661 (20.41/14.54)	TKgNKIAGFEK.EGLQ
 1664- 1678 (22.26/10.77)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     359.00|      56|      56|    1785|    1840|       5
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 1709- 1747 (47.90/21.48)	........................YHTHLKPKPRSYYLEP..........LPLPPE.....EEEPLTPVSQEPEKMIE
 1785- 1840 (110.07/61.54)	PG.PAYTSM..APELMQN....PTYARTMPYNPQNVYTQS..........QPLPPG.....GPGLDAPYRQPTRNQIP
 1854- 1895 (72.29/37.20)	PGmPG..SM...PGIM.G....PDKPYQMTFKPHATMPQA......................PNL....RQQLQHQNP
 1906- 1972 (77.13/40.32)	PN.QQYTSMqtSQAIPQG...yTTYGSHMGM..QQHPSQSgsivphsygnQNFPGA.....HPGANPAVVDPLRQQRP
 1979- 2025 (51.61/23.87)	QA.PGY......PQSMQNtqrfP.........HQQL..QQ..........NPIMPShlgqmGQGVHPGLSRP..NQI.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.36|      24|      26|    1273|    1298|       6
---------------------------------------------------------------------------
 1273- 1298 (34.30/27.08)	CLKSLSEDSSALQDPVLVNIqaQRLL
 1302- 1325 (43.07/28.11)	CYPHRQLDSDDGDNPQRQRI..KRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.47|      15|      54|     582|     597|       7
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  582-  597 (23.60/16.46)	QAPTlTEPGNESERVE
  639-  653 (27.88/15.10)	RSPS.DEPSDESERKE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.15|      39|     198|    1345|    1423|       8
---------------------------------------------------------------------------
   31-   75 (55.18/14.65)	QKEDELTAlNVKQGfnNQPAVSGdehGSAKNVNFNPSKISSNFSS
 1368- 1406 (69.97/48.25)	QKSAEMNS.NNPSG..NGAAVQG...GSASNNNSTTSKMKPILSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.92|       9|     198|      13|      24|       9
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   13-   24 (11.38/13.24)	PLkrPrLGPPDV
  217-  225 (20.53/ 8.75)	PL..P.ANPPDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.81|      13|      15|    1009|    1021|      10
---------------------------------------------------------------------------
 1009- 1021 (24.48/14.92)	MMEAIANPS.ANNF
 1025- 1038 (19.32/10.21)	MVGKILNDSpANRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.58|      11|      49|     654|     667|      12
---------------------------------------------------------------------------
  654-  664 (18.35/17.23)	QDAGSSVKMED
  673-  683 (19.23/ 6.48)	IDHNSSANFDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.10|      19|      58|    2056|    2078|      14
---------------------------------------------------------------------------
 2059- 2078 (35.31/24.51)	LFPQPKQaQQHQQQQQ......QQQQ
 2127- 2151 (30.78/ 9.60)	MFPRAGM.QQTQQQQQtaalvrQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.57|      18|      22|    1539|    1556|      15
---------------------------------------------------------------------------
 1539- 1556 (29.81/20.62)	QQTTEWAVLLLDIIS...SGT
 1560- 1580 (24.76/15.75)	QSNNELFTTVLDMLSvliNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.65|      51|      57|    1040|    1096|      16
---------------------------------------------------------------------------
 1040- 1096 (76.60/82.64)	F...VCNVlmDVC.VDHRDpERVNDIGIL....CAELTAYCRSLSAEwlGILKAlCCSSNNGNCG
 1097- 1155 (74.05/53.71)	FndlLCNV..DVSdLSFHD.SLATFVAILiarqCLLLEDLVRCVAIP..SLLNA.ACSEQDSEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.51|      40|      50|    1442|    1483|      18
---------------------------------------------------------------------------
 1442- 1483 (60.66/44.51)	QHLGSSSRKERDRQKQKSMSLLSQQpfLSLVLTCLKGQ.DE.QR
 1495- 1536 (59.85/36.68)	QQIVTNWREDQYQDDCKAKQMMHEA..LKLRLNLVGGMfDTvQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.05|      32|      87|     713|     744|      19
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  713-  744 (56.58/33.82)	KD......KGMDP.AFPQLYEQPRHIQYATHFPIPQEES
  763-  800 (36.67/19.23)	RDearhtiKKITK.DILKVLNRKSTAETASAYTGGEEGQ
  801-  833 (47.80/27.39)	KR......KRSKPeAFPTAEDIFSKFQHLSHFDQHQVTS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29615 with Med12 domain of Kingdom Metazoa
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