<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29609

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTSANWVANGASLEDCHSNIFSLAELTGIKWRCYRFSSGGEYGPVISAPAQDDPVLRSFMRCVQSNLLCVWRRKIKPDAKELWIFWWGEEPNLTGVIHQELEVGEEGLWECGLSYECRTLLFKAIHNLLERCLTDKGFVRIGKWFFKPHELEEKSLGNTEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEHHIRLAQTSVTPVQVILSPYGLSGTLTGQAYKMSDPAVRKLMEEWSYFYPMVLQQKEGGGEKEKEETSQAYDRNSHVAVEVVVGGVRMTYPAAFVLIAQGDLPVEQPPPVPTAQGLNKELNHCSVPLTPPTSPEQPCSADSGFVTSASSVPTPDSSMSITSISPKHSGKKLTCQVVHQAWRECYLNQPQHVPNQSTEVTPRKEVPNGVTTWDFNDLGARAPCSCSRLKQQKLNLTTASTANSQTSANPTQSSGPSLYTPSLPKHKTSDKTEKGDKQSKRPAVIPFHHRLSVTQESPLEQDSPGGPQLGGLVALDPPIESLATLPTCKYSKPHSNGRKAPESLLHSPVSPLPPTLSPHPRVQDPEAMDGPVDMPVCQDGASGLGVITSETAVYAALLRQRESGAGWWRGFRTPRTDKTDFRPSELPIDKLEEVTTDTTIEGASLKRLYAQAHKKFKISEERVREHIQTLGLFQQPGVEALRDNGDDPYDFKEGDIEYTFSTSKRLKGQGREPSKKAKGEEITSNGALTDGKDAMSIFNSAPKSDESGQDDGAAKTNPSLTREIDLVVNISDLDNILDEDDEEPGTVYPNQHSTKVPVSTEDRPIGKEGRVAVPYPSTVADLQRMFPTPPSLEQHPAFSPIMTYRDTPSQEPPAPTGPADHLPTAASTQLIEHRMEVEDDIGSPRQEDIKPLIGSSMFAPLPCLPSQNLPPLKIPEQCYYRPSWSLLPKMEHFPTVMHPQNSAFTKDGYINIPSVPLADQDYVQMSGATASTSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYTILLLSDSVLSVFKDRNFDSCCICACNQNVKGADVGVYIPDSTGEDQYRCMCGFSAIVNRRLALGTGLFLEDELDIFGRTSEVGRAAERRLALSRRDPTMGDSKAKRPQDAAPASPAVMVLLQEQCSHPISSLASLHLPLSCSCHGRKGALLQSWMSEKQWADGSDACTACYNALEQGLQYVDNPTGGKVDLSVVRSTALHSWPHTNVVDMSMLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYMVVCPNSPSLLSAARSFFLELSAVYETCRLGKHRPLAKVSRDGIVRVGEDVEKEKLEELDVDQWLTGPWVGQQHTDNLNKLKLYAYACKQQLGPQLSALPLDSSLLLPPKAQPPVNNTSSAQPSSSTQEGEQTTGGASSVNASAPTGATSGQTEETQGGASDSKGPPSSTPPANTPAENPELSSEQSRIGIPTVADSVDSHANPPAIVIYIVDAFLSSSGARNDGGEEEEGDEVESSSIWLLGLLRCYTEMLQTLPETTRPALVLQVVPCQYLLQPASGESHLYLQHLRSLAFSCYSQCRRLLPQQTHIKSLTGFGPVSTVSSVLKSPEHPSPLQLYTPPFVLGPSRPKQPEPGEIWAELPPKYNVLFVGYCLSHDQRWLLVSCTDQQGELLETCIINIDVPNRARRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWSSLLGEHSLHSIGRQLREACRMCGISAADSPTILSACLVALEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQLASSSYPTEDNNGNASQDSSYARVIRLFSSRP
Length1940
PositionMiddle
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.06
Grand average of hydropathy-0.414
Instability index58.21
Isoelectric point5.67
Molecular weight212006.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29609
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      18|      21|    1644|    1664|       1
---------------------------------------------------------------------------
 1647- 1664 (34.01/27.27)	Q.HLRSL.AFSCYSQCRRLL
 1667- 1686 (22.54/ 7.12)	QtHIKSLtGFGPVSTVSSVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.60|      16|      21|    1484|    1500|       2
---------------------------------------------------------------------------
 1484- 1499 (29.52/16.62)	PSSSTQ.EGEQTTGGAS
 1506- 1522 (25.09/ 8.39)	PTGATSgQTEETQGGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     974.17|     232|     274|     354|     623|       3
---------------------------------------------------------------------------
  201-  347 (140.11/54.53)	..............................................................................................QTSVTPVQ.......VI.LS...PYGLSGTLTGQAYKMSD..PAVRKLMEEWS.....YFYPMVL.....QQKEGGGEKekeetsqaydrnshvavevvVGGVRMTYPAAFVLiaqGD..LP.V.EQPPP.VPTAQ...GL.NKELNHCSV.......PLTPPTSPeQPCSADS.......................GFVTSASSV....................P...............TP
  354-  623 (376.43/209.98)	TSISPKhSGKKLTCQvVHQAWRECYLNQPQHVPN.QSTE.VTPRKEV..PNGVTT...WDFNDL.GAR..APCSCS.RLKQQKLNLTTASTANSQTSANPTQSSGP...SL.YTPSLPKHKTSDKTEKGDKQSK.RPAVIPFHHRLS.....VTQESPL.....EQDSPGGPQ....................LGGLVALDPPIESL...AT..LP.TCKYSKP.HSNGR...KA.PESLLHSPVS......PLPPTLSP.HPRVQDPEAMDGPV....DMPvCQDGASGLGVITSETAVyaallrqresgagwwrgfrtPrtdktdfrpselpidKL
  630-  849 (248.06/96.90)	TTIEGA.SLKRLYAQ.AHKKFKISEERVREHIQT.LGLF.QQPGVEAlrDNGDDP...YDFKEG.DIE..YTFSTSkRLKGQGREPSKKAKGEEITS.NGALTDGKdamSI.FN.SAPK...SDESGQDDGAAKtNPS.......LTreidlVVNISDLdnildEDDEE..P.......................GTVY...PNQHS...TK..VP.VSTEDRPiGKEGR...VAvP...YPSTVAdlqrmfPTPPSLEQ.HP......AF.SPImtyrDTP.SQEPPAPTG..............................................
  850- 1037 (209.57/79.15)	...........................PADHLPTaASTQlIEHRMEV..EDDIGSprqEDIKPLiGSSmfAPLPC...LPSQ..NLPPLKIPE.QCYYRPSWSLLP...KMeHFPTVMHPQNSAFTKDG..YIN.IPSV.PLADQDY.....VQMSGAT.....ASTS...TT....................TGILPSPATPRFSV...PTprTPrTPRGINT.ASSGQgsvKQ.DGTELSSPVS.......TPSTSLP.LSSV.EPLARPGP.....SLP........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      13|      21|    1689|    1701|       4
---------------------------------------------------------------------------
 1689- 1701 (27.37/15.17)	PEHPSPLQLYT..PP
 1709- 1723 (23.43/11.60)	PKQPEPGEIWAelPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.37|      21|      22|     127|     147|       5
---------------------------------------------------------------------------
   99-  123 (28.74/15.34)	HQELE..VGEEGLWECGLSYecrtllF
  127-  147 (38.28/23.05)	HNLLERCLTDKGFVRIGKWF......F
  150-  170 (36.35/21.48)	HELEEKSLGNTEHLSCSFSF......F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.93|      22|      26|    1315|    1339|       6
---------------------------------------------------------------------------
 1318- 1339 (39.63/28.16)	PLPIPTVLL....GYDRERDFLALSP
 1341- 1366 (36.30/16.61)	ALPFWEKLLlepyGGQRDVAYMVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.30|      36|     634|    1205|    1243|       7
---------------------------------------------------------------------------
 1205- 1243 (57.87/48.82)	ADGSDACTACYNALE.QGlQYVDNPTGgkVDLSVV..RSTAL
 1842- 1880 (55.42/35.43)	ADSPTILSACLVALEpQG.SFVVMPDA..VTMGSVfgRSTAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.33|      21|      26|    1408|    1429|       8
---------------------------------------------------------------------------
 1408- 1429 (33.37/26.86)	VG....EDVEKEKLEELDVDQWLtGP
 1431- 1455 (32.95/21.14)	VGqqhtDNLNKLKLYAYACKQQL.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.24|      16|      22|    1526|    1541|      10
---------------------------------------------------------------------------
 1469- 1483 (21.38/ 7.02)	.PPKAQPPVNNTSSAQ
 1526- 1541 (30.48/13.40)	GPPSSTPPANTPAENP
 1551- 1566 (26.38/10.53)	GIPTVADSVDSHANPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.67|      22|     159|    1104|    1125|      11
---------------------------------------------------------------------------
 1104- 1125 (38.79/20.52)	RLALGTGLFLEDELD..IFGRTSE
 1264- 1287 (35.88/18.48)	RMLLSLQPFLQDAIQkkRTGRTWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      16|      21|    1608|    1626|      12
---------------------------------------------------------------------------
 1608- 1626 (19.99/20.43)	CyTEMLQtlPETTRPALVL
 1631- 1646 (30.06/16.42)	C.QYLLQ..PASGESHLYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29609 with Med13 domain of Kingdom Metazoa
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