<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29608

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTSANWVANGASLEDCHSNIFSLAELTGIKWRCYRFSSGGEYGPVISAPAQDDPVLRSFMRCVQSNLLCVWRRKIKPDAKELWIFWWGEEPNLTGVIHQELEVGEEGLWECGLSYECRTLLFKAIHNLLERCLTDKGFVRIGKWFFKPHELEEKSLGNTEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEHHIRLAQTSVTPVQVILSPYGLSGTLTGQAYKMSDPAVRKLMEEWSYFYPMVLQQKEGGGEKEKEETSQAYDRNSHVAVEVVVGGVRMTYPAAFVLIAQGDLPVEQPPPVPTAQGLNKELNHCSVPLTPPTSPEQPCSADSGFVTSASSVPTPDSSMSITSISPKHSGKKLTCQVVHQAWRECYLNQPQHVPNQSTEVTPRKEVPNGVTTWDFNDLGARAPCSCSRLKQQKLNLTTASTANSQTSANPTQSSGPSLYTPSLPKHKTSDKTEKGDKQSKRPAVIPFHHRLSVTQESPLEQDSPGGPQLGGLVALDPPIESLATLPTCKYSKPHSNGRKAPESLLHSPVSPLPPTLSPHPRVQDPEAMDGPVDMPVCQDGASGLGVITSETAVYAALLRQRESGAGWWRGFRTPRTDKTDFRPSELPIDKLEEVTTDTTIEGASLKRLYAQAHKKFKISEERVREHIQTLGLFQQPGVEALRDNGDDPYDFKEGDIEYTFSTSKRLKGQGREPSKKAKGEEITSNGALTDGKDAMSIFNSAPKSDESGQDDGAAKTNPSLTREIDLVVNISDLDNILDEDDEEPGTVYPNQHSTKVPVSTEDRPIGKEGRVAVPYPSTVADLQRMFPTPPSLEQHPAFSPIMTYRDTPSQEPPAPTGPADHLPTAASTQLIEHRMEVEDDIGSPRQEDIKEIIYVFQPLIGSSMFAPLPCLPSQNLPPLKIPEQCYYRPSWSLLPKMEHFPTVMHPQNSAFTKDGYINIPSVPLADQDYVQMSGATASTSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYTILLLSDSVLSVFKDRNFDSCCICACNQNVKGADVGVYIPDSTGEDQYRCMCGFSAIVNRRLALGTGLFLEDELDIFGRTSEVGRAAERRLALSRRDPTMGDSKAKRPQDAAPASPAVMVLLQEQCSHPISSLASLHLPLSCSCHGRKGALLQSWMSEKQWADGSDACTACYNALEQGLQYVDNPTGGKVDLSVVRSTALHSWPHTNAKVVDMSMLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYMVVCPNSPSLLSAARSFFLELSAVYETCRLGKHRPLAKVSRDGIVRVGEDVEKEKLEELDVDQWLTGPWVGQQHTDNLNKLKLYAYACKQQLGPQLSALPLDSSLLLPPKAQPPVNNTSSAQPSSSTQEGEQTTGGASSVNASAPTGATSGQTEETQGGASDSKGPPSSTPPANTPAENPELYTEACVLCSFFSSSEQSRIGIPTVADSVDSHANPPAIVIYIVDAFLSSSGARNDGGEDIWLLGLLRCYTEMLQTLPETTRPALVLQVVPCQYLLQPASGESHLYLQHLRSLAFSCYSQCRRLLPQQTHIKSLTGFGPVSTVSSVLKSPEHPSPLQLYTPPFVLGPSRPKQPEPGEIWAELPPKYNVLFVGYCLSHDQRWLLVSCTDQQGELLETCIINIDVPNRARRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWSSLLGEHSLHSIGRQLREACRMCGISAADSPTILSACLVALEPQGSFVVMPVYADPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQLASSSYPTEDNNDDMFDLPFPDELENDIGIGIMLNLHSSPNTSPVPSPGSPSGMGMGSHFQHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQANGLPHWFWASCPQAEKQCPLFLKASLHHHISITQSDEIVSEKTKRAPHPLDSKTTSDVLRFVLEQYNALSWLTCTPATQDRQSCLPVHLAILVQMYNAILNML
Length2123
PositionMiddle
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Oreochromini> Oreochromis.
Aromaticity0.07
Grand average of hydropathy-0.387
Instability index58.43
Isoelectric point5.68
Molecular weight232551.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.61|      17|      21|    1657|    1675|       1
---------------------------------------------------------------------------
 1659- 1675 (31.84/22.61)	HLRSL.AFSCYSQCRRLL
 1680- 1697 (24.77/ 9.22)	HIKSLtGFGPVSTVSSVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1025.69|     260|     274|     336|     609|       2
---------------------------------------------------------------------------
  201-  327 (84.54/31.63)	........................................................................................................................................................................QTSVTPVQ.......VILS...PYGLSGTLTGQAY.KMS....D.PAVRKLMEEWSYFYPMVLQ....QKEGGGEKekeetsqaydrnshvavevvVGGVRMTYPAAFVLiaqGDLPV.EQPPP.VPTAQGL...NKELNHCSV.......PLTPPTSP..........
  328-  560 (365.24/185.14)	..................................EQ..........PCSA...dsGFVTSASSVPTPDSSM.SITSISPKHS..GKKLTCQVVHQ.AWRECYLNQPQHVPNQSTEVTPRKEV..PNGVTTWD.FNDLGARAPCSCS.RLKQQKLNLTTASTANS....QTSANPTQSSGP...SLYTPSLPKHKTSDKTEKGD.KQS....KRPAVIPFHHRLSVTQESPLE....QDSPGGPQ....................LGGLVALDPPIESL...ATLPTCKYSKP.HSNGRKA...PESLLHSPVS......PLPPTLSPHPrvqdpeAM
  561-  830 (328.21/173.13)	DGPVDMPVCQDG.ASGLgvitsETAVYAALLRQRESGAGwwrGFRTPRTD...ktDFRPSELPIDKLEEVT.TDTTIEGA.S..LKRLYAQ.AHK.KFKISEERVREHIQTLGLFQQPGVEAlrDNGDDPYD.FKEGDIEYTFSTSkRLKGQGREPSKKAKGEE....ITS.NGALTDGKdamSIFN.SAPK...SDESGQDD.GAA....KTNPSLTREIDL.VVNISDLDnildEDDE.EP.......................GTVY...PNQHS...TKVPVSTEDRPiGKEGRVAvpyP.....STVAdlqrmfPTPPSLEQHP......AF
  838- 1049 (247.69/116.13)	DTPSQEPPAPTGpADHL.....PTAASTQLIEHRMEVED...DIGSPRQEdikeiIYVFQ....PLIGSSMfAPLPCLPSQNlpPLKIPEQCYYRpSW..SLLPKMEHFP...TVMHPQ......NSAFTKDgYINIPS.VPLADQ.DYVQ..MSGATASTSTTtgilPSPATP.RFSVP...TPRTPRTPRGINTASSGQGSvKQDgtelSSPVSTP.STSLPLSSVEPLA....RPGPSLPE....................AHSL.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.60|      16|      21|    1493|    1508|       3
---------------------------------------------------------------------------
 1493- 1508 (29.52/16.08)	PSSSTQ.EGEQTTGGAS
 1515- 1531 (25.09/12.47)	PTGATSgQTEETQGGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.93|      22|      25|    1324|    1348|       4
---------------------------------------------------------------------------
 1327- 1348 (39.63/28.82)	PLPIPTVLL....GYDRERDFLALSP
 1350- 1375 (36.30/16.94)	ALPFWEKLLlepyGGQRDVAYMVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.16|      20|      25|    1889|    1908|       5
---------------------------------------------------------------------------
 1889- 1908 (33.19/17.53)	VFGRSTALNLQTSQLNTPQD
 1916- 1935 (31.89/16.53)	VFPTSSTTQLASSSYPTEDN
 1951- 1968 (25.08/11.27)	DIGIGIMLNLHSSPNTSP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      13|      21|    1700|    1712|       6
---------------------------------------------------------------------------
 1700- 1712 (27.37/12.21)	PEHPSPLQLYT..PP
 1720- 1734 (23.43/ 9.31)	PKQPEPGEIWAelPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.37|      21|      21|     127|     147|       7
---------------------------------------------------------------------------
   99-  123 (28.74/15.25)	HQELE..VGEEGLWECGLSYecrtllF
  127-  147 (38.28/22.86)	HNLLERCLTDKGFVRIGKWF......F
  150-  170 (36.35/21.31)	HELEEKSLGNTEHLSCSFSF......F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.33|      14|      20|    1623|    1638|       8
---------------------------------------------------------------------------
 1623- 1638 (20.27/16.89)	MLQtlPETTRPALVLQ
 1645- 1658 (25.06/13.97)	LLQ..PASGESHLYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.28|      20|      28|    1072|    1098|       9
---------------------------------------------------------------------------
 1072- 1091 (38.20/33.47)	CICACNQNVK...GADVGVYIPD
 1100- 1122 (31.08/11.63)	CMCGFSAIVNrrlALGTGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.42|      10|      55|    1478|    1488|      11
---------------------------------------------------------------------------
 1478- 1488 (17.06/12.22)	PPKAQPPVnNT
 1536- 1545 (21.35/10.31)	PPSSTPPA.NT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.33|      21|      24|    1417|    1438|      12
---------------------------------------------------------------------------
 1417- 1438 (33.37/26.58)	VG....EDVEKEKLEELDVDQWLtGP
 1440- 1464 (32.95/20.87)	VGqqhtDNLNKLKLYAYACKQQL.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.12|      11|      28|    2001|    2011|      13
---------------------------------------------------------------------------
 2001- 2011 (20.03/12.82)	PEELKQQPLAL
 2032- 2042 (22.08/15.16)	PQAEKQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.01|      15|     274|    1742|    1756|      14
---------------------------------------------------------------------------
 1742- 1756 (32.22/18.08)	GYCLSHDQ.....RWLLVSC
 2012- 2031 (27.80/14.60)	GYYVSTAQanglpHWFWASC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29608 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATLPTCKYSKPHSNGRKAPESLLHSPVSPLPPTLSPHPRVQDPEAMDGPVDMPVCQDGA
2) DYVQMSGATASTSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARP
3) LPLDSSLLLPPKAQPPVNNTSSAQPSSSTQEGEQTTGGASSVNASAPTGATSGQTEETQGGASDSKGPPSSTPPANTPAENP
4) NLTTASTANSQTSANPTQSSGPSLYTPSLPKHKTSDKTEKGDKQSKRPAVIPFHHRLSVTQESPLEQDSPGGPQLGGLVALDP
5) PSTVADLQRMFPTPPSLEQHPAFSPIMTYRDTPSQEPPAPTGPADHLPTAASTQLIEHRMEVEDDIGSP
6) SPNTSPVPSPGSPSGMGMGSHFQHTRSQGERLLSRDNPPE
7) STSKRLKGQGREPSKKAKGEEITSNGALTDGKDAMSIFNSAPKSDESGQDDGAAKTNPSLTREIDLVVNISDLDNILDEDDEEPGTVYPNQHSTKVPVSTEDRPIGKEGRVAVP
8) VEQPPPVPTAQGLNKELNHCSVPLTPPTSPEQPCSADSGFVTSASSVPTPDSSMSITSISP
515
960
1469
427
808
1963
693
298
573
1039
1550
509
876
2002
806
358










Molecular Recognition Features






MoRF SequenceStartStop




NANANA