<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29599

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTTETNPPDYYYYIDPQTYYQPQQPNPLDDLISIYNLKDLSKQVARSNLDGTKAVKLRKSYKNQISDLSGKFNIIPTRENGKGGEISNILFQNNADMLSDGSNYMDLKKQNYQEYLQKMKNRDLSLFNLPNIDWNLCNNVISNFEKSYPAEFQNNSIINNFQIDDLAFDFDGTGNLNLSSANSNNTNNVSNPGSTGGTTASSMKNGSQQKKRKNKSNGSSMATPNSEFNDDVKRRRLE
Length238
PositionHead
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.09
Grand average of hydropathy-1.003
Instability index41.70
Isoelectric point7.67
Molecular weight26953.37
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi
transcription open complex formation at RNA polymerase II promoter	GO:0001113	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29599
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.09|      19|      19|     194|     212|       2
---------------------------------------------------------------------------
  173-  190 (21.32/ 8.97)	.TGNLNLSSANSNNTNNVS
  194-  212 (30.03/15.57)	STGGTTASSMKNGSQQKKR
  216-  234 (29.74/15.35)	SNGSSMATPNSEFNDDVKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.10|      31|      90|       9|      40|       3
---------------------------------------------------------------------------
    9-   40 (55.75/33.19)	DYYYYID..PQTYYQPQQPNPLDDLiSIYNLKDL
  100-  132 (52.35/27.19)	DGSNYMDlkKQNYQEYLQKMKNRDL.SLFNLPNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.35|      18|      18|      49|      66|       4
---------------------------------------------------------------------------
   49-   66 (29.50/17.45)	LDGT.KAVKLRKSYK.NQIS
   68-   87 (21.85/11.38)	LSGKfNIIPTRENGKgGEIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29599 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NLSSANSNNTNNVSNPGSTGGTTASSMKNGSQQKKRKNKSNGSSMATPNSEFNDDVKRRRLE
177
238










Molecular Recognition Features






MoRF SequenceStartStop




1) PDYYYYIDPQTYYQP
8
22