<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29597

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAVDLYVETLKKMIEKFQEYKPGSVTLDNITKLCQTLGLESFIDDIGNGVSRLSTASKIIVIDIDFDKIEGKVKDVKLVLASNFDNFNYYNTNIEHKAMDSTTNNNSANDNDDDKSKNILFNSLSEYSTLHEFHHNLQYLYLLDSFSQIEVDPLNSSSVGTGSNTAGTSTNNTNGNSNGHNHNNHVNNHNSNNSSNNTNNDGISSVGNMSSGGTSMISSQGKLDLFKYYTELSQFIDEYFVANNAPFSIATNLNNMFGIYISISGESKPLARIYLEKSRDPQQYFYEYTFSQSSNYWINEHSDSYTMGISLVLEIIDDSSCIFPLDLIPRDLIIELGDNLSNSHNTSNTNSHSNNTNSNYIQTSSSTTNSSSSSSGFSRSSSNQIESNSLFTKMNSMTNLNQHAHKLSNSNSNSNSNCPTVTSSNSNTNQNQSSKNNSNNINSYNKNANTQALSVLDNGSIRSVINIPSYSRKSKFQIMNDFTTKMINIKKFDISNDNLSLILEFLRWVRWSKIILNPVIKLISQSDDTNNVTTSNGNQNSSVNEISSENNNNNSNNNNNPSHFPSRDNLEQAHELPINSNQIHSSLSSNAGELYPHSMSVSNGKRRRSSNKSKRPSLTEASILKDEGFQQFNLHEIMTESVIEEENMVFDHMDSFSSPKISSSFNDVSTFVDEALGNNTNAIANNSGKIEFPIKTNNNYAPEKLYKTASPKYLIISEDCVAIDKGISCNIYDDVEKWKIFIDTFISHF
Length749
PositionMiddle
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.08
Grand average of hydropathy-0.655
Instability index43.31
Isoelectric point5.27
Molecular weight83519.27
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     355.06|      48|      55|     351|     398|       1
---------------------------------------------------------------------------
  184-  236 (48.39/12.52)	NHVN.NHNSN..NS.SNNT......NNDGI..............S..SVGnMSSGGTSMISSQGkldlfkY..........YTELS...Q.................................FI
  251-  306 (44.98/11.10)	TNLN.NMFGIYISI.SGES......KPLARiyleksrdpqqyfyE..YT..FSQSSNYWINEHS.....................D...S.................................YT
  351-  398 (83.32/27.06)	SHSN.NTNSNYIQT.SSST......TNSSS..............S..SSG.FSRSSSNQIESNS......L..........FTKMN...S.................................MT
  408-  439 (41.59/ 9.69)	SNSNsNSNSN......CPT......VTSSN..............S..NTN.QNQSSKN...........................N...S..................................N
  443-  523 (33.83/ 6.46)	SYNK.NANTQALSVlDNGS......IRSVI..............N..IPS.YSRKSKFQI.MND......F..........TTKMI...NikkfdisndnlslileflrwvrwskiilnpvikLI
  524-  571 (57.69/16.39)	SQSD.DTNN..VTT.SNGN......QNSSV..............NeiSSE.NNNNNSNNNNNPS......H..........FPSRD...N.................................LE
  573-  639 (45.25/11.21)	AHEL.PINSNQIHS.SLSSnagelyPHSMS..............V..SNG.KRRRSSNKSKRPS......LteasilkdegFQQFNlheI.................................MT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.71|      10|      16|     155|     164|       2
---------------------------------------------------------------------------
  155-  164 (17.40/ 7.78)	NSSSVGTGSN
  174-  183 (20.31/10.57)	NGNSNGHNHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.16|      12|      16|      86|      97|       3
---------------------------------------------------------------------------
   86-   97 (23.41/12.68)	NFNYYNTNIEHK
  104-  115 (21.75/11.14)	NNNSANDNDDDK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29597 with Med1 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NLSNSHNTSNTNSHSNNTNSNYIQTSSSTTNSSSSSSGFSR
2) NSLFTKMNSMTNLNQHAHKLSNSNSNSNSNCPTVTSSNSNTNQNQSSKNNSNNINSYNKNAN
3) QSDDTNNVTTSNGNQNSSVNEISSENNNNNSNNNNNPSHFPSRDNLEQAHELPINSNQI
4) SSLSSNAGELYPHSMSVSNGKRRRSSNKSKRPSLTEAS
5) SSVGTGSNTAGTSTNNTNGNSNGHNHNNHVNNHNSNNSSNNTNNDGISSVG
339
388
525
585
157
379
449
583
622
207










Molecular Recognition Features






MoRF SequenceStartStop




NANANA