<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29590

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKRALSLPMNKQSSYRLEELYSSFFQIAHIDKINYHQYVFGKHDEKLIIDLEFKLRKSHPTVLVAIFSRELWCFSLNDSKLESPQLDSETFNNHLEFDKNGHFDANYSKPNLPIYYAIFLKALRKTIYINITINSNNTLIPFANTMISIRETRHHDSSNLFQISPHLFENGQLTLLLSIIQLDLIPLKLDHINNEFFCKNNALYFAPSGIRMSLFSPNANAMTKPPQDYQTLLNILEVSHGIIFPDVNSIHWIKIIPQISHLNGITPSIARYLANQSDNRFLIWPLELCFAQRPFDSPLETSSGVSSWKFNQTQELHSTFQILDDFINLKQSSSLRTPGSTSGGGFGIGTNLPMSSGGGYTDQLQHFYKNINSTGAIPNSNTQSEKHKFSPNDLTKFSPLDQPFPNSNEPFHPVLLNTPTNDLFMENNNNRKLSSPNYTELSDKNIRLSTDQFSTGSNPTPIKNEVILNDTLVDRELFGDDDDDDDDEDLFGELNDSSNDDNNVTALKLSTKSNSDEVTEEMFDMSDDEDIRTSSSKKEQYCLTTNDNAKLTNTKKHGLKRKYLDIPIDEMTLPTTPLYMDPGAPLPVETPKDRKKSVFAPLNFNPIIESNVDNKYKNGGKFSFSPQQIEEALNFDISTANISSSDDDDDDDDDDDDDDDDDEVNDVNDNLNNSIDEDIPIDHFPAETQLLSYAPLQVVPNEQLTSELIRNIPQQQINFPTNEIPKDKDNMNSIWKLPQYDIQRTISPIRGVENSIPLNENINTNKTSANEDHLFAKNTIDQDHHTTLTEPGRRSVRSDLSNEISMTKDNNNNITTATTKQDQVVLDDKDKLQEFTTNFPFLLRHLPLSSMPLTFSCFNPQVKINLKHQNILNLMAEQIVYDYDMLNQLGVPNYNFKCIENVNEGLISNTLTNIFNEFERIDGNNLISNIYSMKQPSVIVKKHHSTVKIRADSYEFGKYLNLKPANGLKNFRFLLLTTDFKDDCASFVSTFCQTYIGFEYGFCELPKLTNDHIQGLIVLKDLEEQKLLLLAAQIVSYCSNNKGTGNDVPLLIMLPLFNNTLIELVRMISKFEIIQNEVRLRIPNVEILLKVIPIDFIKSPLTSVDDYTSLSIGIYNLLPSKSTKFATIAPSFENKISFSNSVGNPHSTIHYDSFIHLAYARSVDKRWVFAAFSDSTGSLHTIRTWYVGTSNTKFDRACDEIWQIAMQIAVTKYGRICMILTRLNNVLPDDELMNWRHLSSRNVHLAVVCVDNSSRISFIDNDKFCPSFKPLIHNPNLEKKLNPKKLNDYELRDIDQDVYCAIFENSLPLANSQHRCAIKSGALIKFDTHNNKNDSESRTWDTFEVNLLNCPHSNSTQLFEAILEEFRNLSSLNTWFSVSKGNRTNVPWHVLAVEKMMNTMVYTDVLIPE
Length1409
PositionKinase
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.09
Grand average of hydropathy-0.463
Instability index39.36
Isoelectric point5.11
Molecular weight160701.72
Publications
PubMed=22123960

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29590
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.88|      55|      57|     828|     883|       1
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  828-  880 (83.27/59.98)	..........................DKDK..LQEF.TT.......NFPF.LLRHL..PLSSMPLTfSCFN...................PQVK..INLK...HQNILNLMAEQIV
  881-  953 (44.66/25.33)	YDY...........................dmLNQLgVP.......NYNFkCIENVneGLISNTLT.NIFNeferidgnnlisniysmkqPSVI..VK.K...HHSTVKIRADS..
  954- 1035 (49.94/29.36)	YEFgkylnlkpanglknfrflllttdFKDD..CASF.VStfcqtyiGFEY.GFCEL..P....KLT....N...................DHIQglIVLKdleEQKLL.LLAAQIV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     203.10|      43|      43|     390|     432|       2
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  390-  423 (56.54/28.57)	...................SPNDLT............K..FSPLD.QPFPNSNEPFHPVLLNTPTND..L
  424-  477 (42.46/19.37)	FMENNNNRK........lsSPN.YTelsdknirlstdQ..FSTGS.NPTPIKNE....VILNDTLVDreL
  478-  531 (47.04/22.36)	FGDDDDDDDdedlfgelndSSNDDN............N..VTALKlSTKSNSDEVTEEMFDMSDDED..I
  542-  578 (34.35/14.07)	CLTTNDNAK.ltntkkhglKR................K..Y..LD.IPIDE.........MTLPTTP..L
  579-  611 (22.71/ 6.47)	YMDPGAPLP........veTPKDRK............KsvFAPLNfNPIIESN.................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     341.39|     128|     920|     136|     291|       3
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   74-  208 (198.57/142.71)	FSLNDSKLESPQLDSETFNNHLEFDKNGHF.DANySKPNLPIYYAI.FLKALRKTIYINITINSN....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ntLIP.FANTMISIreTRHHDSSNLFQISPHLfENGQLTLLLSIIQLDLIPLKLDHInNEFFCKNNALY.FAPS
  215-  278 (70.74/58.85)	FSPNANAMTKPPQDYQTLLNILEVSHGIIFpDVN.SIHWIKIIPQIsHLNGITPSIARYLANQSD..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1053- 1120 (72.08/28.90)	.................................................................nrfliwplelcfaqrpfdspletssgvsswkfnqtqelhstfqilddfinlkqssslrtpgstsgggfgigtnlpmssgggytdqlqhfykninstgaipnsntqsekhkfspndltkfspldqpfpnsnepfhpvllntptndlfmennnnrklsspnytelsdknirlstdqfstgsnptpiknevilndtlvdrelfgddddddddedlfgelndssnddnnvtalklstksnsdevteemfdmsddedirtssskkeqyclttndnakltntkkhglkrkyldipidemtlpttplymdpgaplpvetpkdrkksvfaplnfnpiiesnvdnkyknggkfsfspqqieealnfdistanisssdddddddddddddddddevndvndnlnnsidedipidhfpaetqllsyaplqvvpneqltselirnipqqqinfptneipkdkdnmnsiwklpqydiqrtispirgvensiplnenintnktsanedhlfakntidqdhhttltepgrrsvrsdlsneismtkdnnnnittattkqdqvvlddkdklqefttnfpfllrhlplssmpltfscfnpqvkinlkhqnilnlmaeqivydydmlnqlgvpnynfkcienvneglisntltnifneferidgnnlisniysmkqpsvivkkhhstvkiradsyefgkylnlkpanglknfrflllttdfkddcasfvstfcqtyigfeygfcelpkltndhiqglivlkdleeqkllllaaqivsycsnnkgtgndvplliMLPlFNNTLIEL..VRMISKFEIIQNEVRL.RIPNVEILLKVIPIDFIKSPLTSV.DDYTSLSIGIYnLLPS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29590 with Med13 domain of Kingdom Fungi
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