<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29589

Description Uncharacterized protein
SequenceMEAKASVEERAQNVQDLLQVLMNINTINGGNSDTAQNMKVHAKNFEAALYTKSSSKKEYMDNMHEKVRKMRETLDKRKKDLILQQNKQRQVQAQAQAQAQQKHSMQMQMQAQMQPQGQSQGQGQGQSQQSQQQPQSQQQPQNLAQAYPQMNPQMFLNQQAQARQQVAQQLRNQHAPHQPSEPTASPAPPRPQFTSQQQQIINQMKIAPIPQELLDRLPRIPPGVNTWQQITELAQQGRLSASDMKAAKEVYKLHQQLLYAKRPQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQQQQQPQQQQPQQQQPQQQQPQSQQQPQQEPPNVLGQIHQIFSPDEQKALLQEAMEACKTFQKNHCTPSTAAQFNKQAFIRKYINQKALRKIQSIRQLQRQQSNANANAPASASANNNNNNNNNNNNNNNNNNNNNNNNNNNANNQPPSQVPASANSNAPAPPPPSSNPAAPPQAAATAAAPPRQSIMQAFAPTQQDIEIVKRISAEAARTPLRLSDITNSLSMQERDEIKRKLQLNQQLFAQVSNYTPQVYILTKNENFLKEVLQLRIFVKEIIEKCSKGIYVVKLDTVDKLIVKYQKYWESMKIQILKRQQMIRQAQSQSQTQPQSQPQTQQQSQPQTQPQSQPQSQQQQQQQQSQQQQQQYNNISQNQQRVQGSIQHIQQQFHYQQSPSPNSMSQQPHSRSQSQNTPQLQFQRKQSNSQPNIYNQMQNNQMNSQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQAQAQAQQSKASSQRAYANSPSHPQSISPSKNTRKSSIPPNIRSKQQSSNSNSTSNSTSNSNANTPSSSTNIKKKSPSASNKGTPQTIMTTGTTPNLQNNATLSQTIINSPSNSNSMLKNNNSINSLSPFSNIQPINFNPALNMTSASNDNPFKNEELNLKQLNINKMEIISRYKHRRELLSNSPMDLFLSTLGDCLGKNDHDLELVKPIPKAVSDFINGTGKKKITKNIQKLRDQDVVNVSITNNNKNLIMDSKFLRNNNNNNNSHPEFSSSSLPQSNYKIDRNSLYSVFNCINNKNINFSTNSNSTSTNSISNKQNLIPPTPMESNNLKKRKLDDLEISPSNSSPTQTFTMSESKKIKIDSPEDMFNNSTAKIQNSKLQNQVNIWDWDFWSQTQTN
Length1234
PositionTail
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.04
Grand average of hydropathy-1.181
Instability index70.05
Isoelectric point9.95
Molecular weight138560.18
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29589
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.19|      15|      15|     731|     745|       1
---------------------------------------------------------------------------
  271-  285 (30.46/ 6.16)	QQQQQQQQQQQQQQQ
  286-  300 (32.73/ 7.36)	QQQQPQQQQQQQQQP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     173.97|      15|      15|     803|     817|       5
---------------------------------------------------------------------------
  106-  120 (28.34/ 6.66)	QMQMQAQMQPQGQSQ
  623-  637 (29.35/ 7.31)	QPQTQQQSQPQTQPQ
  639-  652 (28.53/ 6.78)	QPQSQQQQQQQ.QSQ
  763-  777 (29.91/ 7.67)	QAQAQAQAQAQAQAQ
  813-  827 (29.91/ 7.67)	QAQAQAQAQAQAQAQ
  829-  843 (27.92/ 6.40)	QAQAQAHAQAQAQAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.45|      18|      23|     947|     968|       7
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  955-  978 (22.54/11.25)	KNNNSINSlspfSNiqPINFNPAL
 1094- 1111 (28.91/ 8.00)	RNNNNNNN....SH..PEFSSSSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.94|      18|      23|     438|     460|       8
---------------------------------------------------------------------------
  438-  459 (27.49/15.96)	NNQPPSQVPASAnsnApAPPPP
  462-  479 (35.45/11.14)	NPAAPPQAAATA...A.APPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.82|      19|      21|     884|     902|      10
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  884-  902 (36.33/17.96)	SSNSNSTSNSTSNSNANTP
  903-  921 (30.49/13.73)	SSSTNIKKKSPSASNKGTP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.10|      35|      35|     164|     198|      13
---------------------------------------------------------------------------
  159-  196 (51.49/12.43)	QAqarQQ.........VAQQLRNQHAP......HQPSEPTASPAPPRPQ........FT.SQ
  236-  270 (38.31/ 6.63)	QG...RL.........SASDMKAAKEV......YKLHQQLLYAKRPQQQ........QQ.QQ
  301-  339 (44.17/ 9.21)	QQ...QQ.........PQQQQPQQQQP......QSQQQPQQEP....PNvlgqihqiFS.PD
  662-  712 (41.14/ 7.88)	SQ...NQqrvqgsiqhIQQQFHYQQSPspnsmsQQPHSRSQSQNTPQLQ........FQrKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.92|      13|      23|    1034|    1055|      14
---------------------------------------------------------------------------
 1034- 1050 (16.49/12.36)	GKNDhdleLVKPIPKAV
 1058- 1070 (20.43/13.62)	GKKK....ITKNIQKLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      14|      16|    1121|    1136|      15
---------------------------------------------------------------------------
 1121- 1134 (26.23/19.65)	NSLYSVFNCINNKN
 1140- 1153 (23.92/ 9.47)	NSNSTSTNSISNKQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.62|      22|      23|    1154|    1175|      16
---------------------------------------------------------------------------
 1154- 1175 (38.04/21.39)	NLIPPTPMESNNLKKRKLDDLE
 1180- 1201 (37.58/21.04)	NSSPTQTFTMSESKKIKIDSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.86|      25|      28|     521|     547|      17
---------------------------------------------------------------------------
  521-  547 (37.44/29.38)	RDE..IKRKLQLnqQLFAQ..VSNYTPQVYI
  550-  578 (31.42/17.56)	KNEnfLKEVLQL..RIFVKeiIEKCSKGIYV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29589 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRQAQSQSQTQPQSQPQTQQQSQPQTQPQSQPQSQQQQQQQQSQQQQQQYNNISQNQQRVQGSIQHIQQQFHYQQSPSPNSMSQQPHSRSQSQNTPQLQFQRKQSNSQPNIYNQMQNNQMNSQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQAQAQAQQSKASSQRAYANSPSHPQSISPSKNTRKSSIPPNIRSKQQSSNSNSTSNSTSNSNANTPSSSTNIKKKSPSASNKGTPQTIMTTGTTPNLQNNATLSQTIINSPSNSNSMLKNNNSINS
2) NSNSTSTNSISNKQNLIPPTPMESNNLKKRKLDDLEISPSNSSPTQTFTMSESKKIKIDSPEDMFNNSTAKI
3) NTINGGNSDTAQNMKVHAKNFEAALYTKSSSKKEYMDNMHEKVRKMRETLDKRKKDLILQQNKQRQVQAQAQAQAQQKHSMQMQMQAQMQPQGQSQGQGQGQSQQSQQQPQSQQQPQNLAQAYPQMNPQMFLNQQAQARQQVAQQLRNQHAPHQPSEPTASPAPPRPQFTSQQQQIINQMKIAPIPQELLDRLPRIPPGVNTWQQITELAQQGRLSASDMKAAKEVYKLHQQLLYAKRPQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQQQQQPQQQQPQQQQPQQQQPQSQQQPQQEPPNVLGQIHQIFSPDEQKALLQEAMEACKTFQKNHCTPSTAAQFNKQAFIRKYINQKALRKIQSIRQLQRQQSNANANAPASASANNNNNNNNNNNNNNNNNNNNNNNNNNNANNQPPSQVPASANSNAPAPPPPSSNPAAPPQAAATAAAPPRQSIMQAFAP
609
1140
25
962
1211
487










Molecular Recognition Features






MoRF SequenceStartStop




1) IWDWDFWS
1222
1229