<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29588

Description Uncharacterized protein
SequenceMQQNIGFSWGFQPQISTTRRTSTFKNVSSNSSGNTGHNLHSNHDNNAISSNNNSIASNSLMMIDSSTQVSKKRKLIYETNTPELNNISNNSHPNNNNLFLRMQQQQQQQQQQQQQHNQNLSQNHRKITVIKRKHYIASNIEGQSLPIQRGMELMNKQQISDLLLSLAVKYPHLNNDIINHVSTINFSVENYKRLLDEKLQLIKNNIPYDKYNNQISISSDSNYIINNLNAYSFNRLKPYILDFLNCLIDCILNNLPPIQENIITSIKFLIYCNELLISLPRFSDSSNNYYYDKCLEQLTHIWLSIINRLNGEIQFLINSKDFLFEIEKKLNLFNKITGMYNKVIQELGNLVESINYEFNDKNTNTSPNATATTSTNPTNPTI
Length382
PositionTail
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.08
Grand average of hydropathy-0.615
Instability index44.65
Isoelectric point8.84
Molecular weight44101.05
Publications
PubMed=22123960

Function

Annotated function Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. 
ECO:0000256	RuleBase:RU368013
GO - Cellular Component
nucleus	GO:0005634	IEA:InterPro
GO - Biological Function
GO - Biological Process
nuclear protein quality control by the ubiquitin-proteasome system	GO:0071630	IEA:InterPro
proteasome localization	GO:0031144	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29588
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.28|      42|      46|     252|     297|       1
---------------------------------------------------------------------------
  171-  229 (33.97/ 9.36)	PHLNNDII.nhvSTINFSVenykrlldeklqliknnipydkYNNQISIS........SDS..NYIINN.LN.
  256-  297 (75.97/39.14)	PPIQENII....TSIKFLI......................YCNELLISLPR....FSDSSNNYYYDKCLEQ
  299-  346 (52.35/19.40)	THIWLSIInrlnGEIQFLI......................NSKDFLFEIEKklnlFNKITG..MYNKVIQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.57|      20|      51|      86|     105|       3
---------------------------------------------------------------------------
   86-  105 (35.50/18.92)	NISNNSHPNNNNLFLRMQQQ
  108-  123 (25.99/11.85)	QQQQQQQQHNQNL....SQN
  139-  158 (33.08/17.12)	NIEGQSLPIQRGMELMNKQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29588 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKRKLIYETNTPELNNISNNSHPNNNNLFLRMQQQQQQQQQQQQQHNQNLSQNHRKIT
2) TRRTSTFKNVSSNSSGNTGHNLHSNHDNNAISSNNNSIASNSLMMID
71
18
128
64










Molecular Recognition Features






MoRF SequenceStartStop




1) IGFSWG
5
10