<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29584

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSTKLDSTGKSATATATSPVNNASSFTNGKDLAIQNQHQNNDHGTSNNISSSEYTDKTSNLDDTKEYLNQQHKNIDNHAVIENHYSDGKDKSPTNDNMGEILNNPPEIQHVEINQLPLSKIIRNLTVYTIKEISQYMKTNNHTNGPTSSATSANGSGDMNSSSSRKIRFLKLIIFLRNQFLKLYVLIKWCKTIKNNNFNIMIDLLNWFRSTNLTVNNCIWLLKNNITNMNNAKLPNVDLVTSLEVLSLGKPNFSSNSTRQTYDNNSSSNLLSLDTSIIDKNIKIPPDLILNKLHDLNILISTKLALMNIPEQFNNYIIKDGRVYITAKNEFEIQLATIDRKSPLFFVDLKLNFFNNNQIFIPINKIKFEKIINEILFKSKNPLFALYKFLHKYIISLQLFLIHNELLILENDGKFNGGNLVHRYDSKKNIISIRYWLNVHMGNKGKIIIGIDRKSDNLILKWDHDIAKNSRLPTNYFDILTNLESVLDEIMFNHAHLIRAELLSKGIFQEDEENSDVLLFQMPTTCLSVAPIQLKIDLKSGVFYFKNPTSLLQLYTKKINMANTAEELTTVLQNLKLDKIKQVLRNMFEKTGWVCSSAVKLDKPIQTKFNIINTYNNNSSSSNNNNNKAKQDGSPARTNNEVEKYTLLQDDIFICLPSWPAHWYLILTIISSNTSCVIEKRVGKVMSVNGKWQIVYMDDSNVNPVKLETMTYKKIMHLQKSILRKIINHMIIDSLNQLKISNKICSSEKILSILPDYISVTSKPTPGTTSSAIVNSSTVTSNITPTQIPHNNDYSPIIALELNSFLDGSVASNTALESSMFLRIDYSTSEIKLFGRFKRDIMSLKCRCDELMINLVKTDPLAFYLGKKFSNLNFIVQYLTEFKQKLFQLVVVTDVVERLHKNFASDTFEIVALKPNEISFKYLKDGLDSNDCTIQIQDKDKIMEKLSITLSPSNPQHIIQPFIENEKMDYHFVFNYLQFTSSLFATLQQIVTNNQTKLEESQTIVSFGLHNLYSYQIIFFLPPINKTFNILVDLKNVSHNEYCKMKYYIHFSKKEENLAIKSPGYSLVRKIQKNIFSLDTINKDNIKKYPTAIRLSAGICCDSEDVEFILKDITKIFDNYDSVDTPTGGSTGGIPTPALTAAM
Length1143
PositionTail
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.09
Grand average of hydropathy-0.280
Instability index36.08
Isoelectric point8.83
Molecular weight130333.07
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
TFIIB-class transcription factor binding	GO:0001093	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29584
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.90|      73|      96|     849|     923|       1
---------------------------------------------------------------------------
  849-  923 (111.75/73.58)	DELMINLVKTDPLAF...YLGKKFSNLNFIVQYLtEFKQKLFQLV..VVTDVVERLHKNFASDTFEIVALKPNEISFkYL
  944- 1021 (114.15/67.26)	EKLSITLSPSNPQHIiqpFIENEKMDYHFVFNYL.QFTSSLFATLqqIVTNNQTKLEESQTIVSFGLHNLYSYQIIF.FL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.41|      27|      27|     170|     196|       2
---------------------------------------------------------------------------
  170-  196 (46.73/27.36)	LKLIIFLRNQFLKLYVLIKWC.KTIKNN
  198-  225 (45.68/26.58)	FNIMIDLLNWFRSTNLTVNNCiWLLKNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     578.48|     134|     352|     248|     383|       3
---------------------------------------------------------------------------
  248-  383 (212.17/127.46)	LGKPNFSSNSTRQTYDNNSSS.....NLLS....LDTSIID.K.NIKIPPD.....LILNKLHDLNILISTKLA....LMNIPEQfNNYIIKDGRVYItAKNEFEIQLATIDRKSPLFFVD......L...KLNFFNN.NQIFIPINKIKFEKIINEILFKSKNPL
  412-  496 (97.79/50.94)	DGK..FNGGNLVHRYD..SKK.....NIISirywLNVHMGN.KgKIIIGIDrksdnLILKWDHD.........................IAKNSRL...PTNYFDI.LT........................................NLESVLDEIMFNHAH..
  497-  584 (96.00/49.86)	LIRAELLSKGIFQEDEENSDV.....LLFQ....MPTTCLSvA.PIQLKID.....L..................................KSGVFYF...............KNPTSLLQ......LytkKINMANTaEELTTVLQNLKLDK.IKQVL.......
  601-  738 (172.52/95.89)	LDKPIQTKFNIINTYNNNSSSsnnnnNKAK....QDGSPAR.T.NNEVEKY.....TLLQ..DDIFICLPSWPAhwylILTIISS.NTSCVIEKRVG.........KVMSVNGKWQIVYMDdsnvnpV...KLETMTY.KKI.MHLQKSILRKIINHMIIDSLNQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.84|      25|      56|      73|      97|       4
---------------------------------------------------------------------------
   39-   63 (33.33/19.45)	QNND.HGTSNNiSSSEYTDKTSNLDD
   73-   97 (45.23/29.52)	KNIDNHAVIEN.HYSDGKDKSPTNDN
  131-  154 (38.27/23.63)	KEISQYMKTNN.H.TNGPTSSATSAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29584 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTKLDSTGKSATATATSPVNNASSFTNGKDLAIQNQHQNNDHGTSNNISSSEYTDKTSNLDDTKEYLNQQHKNIDNHAVIENHYSDGKDKSPTNDNMGEILNNPPEIQ
1
109










Molecular Recognition Features






MoRF SequenceStartStop




NANANA