<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29583

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAHNTSNATNNSTVYDLAIKCANRQISSVDFLNLYNEFYNENLAPKYIDNDQSTKEENFQLVKIYNELSDDFIKILNSNGNLLLAEYMVQILFINYDSKLMHEFIPKIYSITNNSMLFHFFSKICVFLLKLSDKLILDQIAKDSADLIIPNVLSLNLNNMANELIVSIAKFLQLLIMKIVEVNNANSNNTAADSANGNHLNNSPNTTNSHISGSTASNMHSIMILSENSRENSLNLINKLNSINKLLCKKITQLFDSNLSFKDSKPLFPRDLQHEYARSPSISSPQFISSPKPSLKTPANTSNIGLNSTQHRYTKLLRYYKNIWLNNKIINWETFDSNFLRKYSLIFSNISKDSISAPSTIGNLLMDLIDTSFICFAQFVSNKQYHQSNSNFTLLEKKWITFITKHIPLLILEHVSNINNPTFNIGGNNVNSNNTAQTIVTNVLSKMDEKIIKALKSYAAEKEDFKTRTEDLFDDYPSNNLDIRHDFIKNLVMLGLQPASLINEYLIEDQMIDTHTLLINDDLIVQNTQGIDEIIYDSKLFVENALNSLESDFLNIENIPMVNGLQQVLNNFDNIAPTRQKEISTIILNVLLKSVKEFDCIKVSRICSLLSFNFSHSLNTILTYIKPFKIAEILMEFIDIKWEKMNDIKKKELGDVEQEILYLFSSFGWSLVLLITLYKTYDISLVEVASISKYLNTKNSFVIEFITKLPEIPDDLQFHKASEDDNSESENLYPLVQNWVRDLFINGSLSDPLVQNISAKQLSVLLPHIFKQIILAIEISDMTDITTILGGFEYFLQPFMLVGSIKIIYWLDQYLASLKTDSISDQFLQNIASILNCLLNPPNLNEDSRALHKAILRLNAPHLIKVLRRFRSSSQSNYNVYSSDSQGSSSIETVITSLISALSVSPCYDLDPRIINNENTFSQKKLGYEKFLILNENPMNKIMSNQMNLFWNMHSSTYYNLDYLYQVIHLVTPKSFLFDILQSLEFKMNTYFAANTIRKNSVSIDMDSVLDHVFYFLVLHDIGSKKEADEFLKLLDKDGQLSNENNNVNDYSEQKSLHTATSTINTSNNDTSNNSNNNNSTNDDISNNDTSNPDNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEIVSNEPQNSENIKQETQQTQLNSDPILDDDFDMLFGENDTSMHGQDDDLGLQQDTLDEENPIEMIKDEAEKPNLEVTNQSSNYVMLKKDTFGWILYELKMAQDEINDSSKMEVTQKEKISKYYDKYLDMLKTCIF
Length1267
PositionTail
OrganismTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.09
Grand average of hydropathy-0.368
Instability index40.13
Isoelectric point4.92
Molecular weight144951.59
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
histone H3 acetylation	GO:0043966	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblFungi
transcription by RNA polymerase II	GO:0006366	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29583
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.40|      18|      18|    1095|    1112|       1
---------------------------------------------------------------------------
  183-  199 (26.69/ 8.27)	NN.ANSNNTAAD.SANGNH
  200-  217 (24.43/ 6.83)	LN.NSPNTTNSHISGSTAS
 1092- 1110 (32.51/11.97)	NPdNNINNNNNNNNNNNNN
 1111- 1129 (32.77/12.14)	NNnNNNNNNNNNNNNNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.36|      15|      16|      94|     108|       2
---------------------------------------------------------------------------
   94-  108 (26.83/15.51)	INYDSKLMHEFIPKI
  111-  124 (20.96/10.23)	ITNNSMLFH.FFSKI
  125-  139 (16.57/ 6.27)	CVFLLKLSDKLILDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.77|      13|      16|     501|     513|       3
---------------------------------------------------------------------------
  501-  513 (24.47/12.73)	LINEYLI..EDQMID
  518-  532 (19.29/ 8.53)	LINDDLIvqNTQGID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.46|      11|      17|    1061|    1072|       4
---------------------------------------------------------------------------
 1061- 1072 (16.44/ 8.29)	TSTiNTSNNDTS
 1081- 1091 (20.02/ 6.82)	TND.DISNNDTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.17|      13|      22|     601|     614|       5
---------------------------------------------------------------------------
  601-  614 (18.98/21.39)	IKVSRICSLLsFNF
  625-  637 (23.19/19.08)	IKPFKIAEIL.MEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.72|      24|      43|      19|      44|       6
---------------------------------------------------------------------------
   19-   44 (34.43/26.44)	IKCANrQISSvDFLNLYNEFYNENLA
   62-   85 (40.29/21.78)	VKIYN.ELSD.DFIKILNSNGNLLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.04|      26|      69|     472|     497|       7
---------------------------------------------------------------------------
  472-  497 (48.53/28.00)	LFDD..YPSNNLD.IRHDF..IKNLVML.GLQ
  535-  566 (28.51/13.28)	IYDSklFVENALNsLESDFlnIENIPMVnGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.32|      21|      69|     152|     179|       8
---------------------------------------------------------------------------
  152-  179 (26.44/26.84)	VL.......SLNLNNMANelivSIAKflqLLIMKI
  224-  251 (30.88/14.08)	ILsensrenSLNLINKLN....SINK...LLCKKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.32|      21|      48|    1180|    1200|       9
---------------------------------------------------------------------------
 1150- 1178 (22.06/10.93)	QTQLNSDPiLDDdfdmlfgENDTSMHGQD
 1180- 1200 (34.62/22.25)	DLGLQQDT.LDE.......ENPIEMIKDE
 1229- 1249 (29.64/17.77)	ELKMAQDE.IND.......SSKMEVTQKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.43|      28|      71|     739|     767|      10
---------------------------------------------------------------------------
  718-  743 (18.91/ 6.72)	FHKASE..................DDnsesenlyPLVQ.......................................nWVRDL
  744-  799 (30.32/19.93)	FINGSL..................SD........PLVQNIsAKQLSVLL.PhifkqiilaieisdmtdittilggfeyFLQPF
  800-  841 (19.20/ 6.94)	MLVGSIkiiywldqylaslktdsiSD........QFLQNI.ASILNCLLnP................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.57|      19|      65|     339|     362|      12
---------------------------------------------------------------------------
  316-  337 (28.79/10.27)	LLRYYKNIWLNnkiINWETFDS
  339-  357 (30.78/25.71)	FLRKYSLIFSN...ISKDSISA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29583 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLLDKDGQLSNENNNVNDYSEQKSLHTATSTINTSNNDTSNNSNNNNSTNDDISNNDTSNPDNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEIVSNEPQNSENIKQETQQTQLNSDPILDDDFDMLFGENDTSMHGQDDDLGLQQDTLDEENPIEMIKDEAEKPNLEVTNQSS
1033
1213










Molecular Recognition Features






MoRF SequenceStartStop




1) DDFDMLFGE
1161
1169