<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29563

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSNQASTSTAHGGGAGHSNMAHTPGAFAPHARHASLANSPSGHRRIGGLGPAQHASPSSSPAFPRPFANVASFPGTVSAPRSAAPPNSLSAQHRSIQHLPSLTTLTPTSLAKVPFPADTHVYWLHLSRRNPQPASVSDHQAGQQDAIMTAATSSARSLEELKSAWDLGIAQVLAAARKARARSQAADTSSQPENAGFKRLLGGGPLVYTSSANPSSNDTAAHRLDAPSRCAIADLWLFLAITKDTEAPSKATNAIADATSSTRAQSGDITTPKAESSAKDGVKRGSSTHLVSILDPTVARHLSSDVAKAMARLALLADTSTGSYPLASATSTPVDRKGKEPSLTSEQRAAHKRFMTSLKARAIDSIVNQSAALPVKPQEPGMTEMVGTQPQIKRRRLRLGDRIVFLPLCRDDLIKSTTADASFFSTPGNASTTADGTDQHSFTTDVDLSLCSNTLLVRAISRRLAATPLASTRHAQGSKSDRPGPTRARLLLAPLGCHAEILGVIAMTRFADEQLADLRSMFASVDDDLASHRPGDTDSLASGLAVCTFPPTQPQRLIPQTHLQPNEQPREPFTPNGPVDMNMDLDALPTVEHHEQQGLQQQQQQQRSSQEQSQEARQFLWPVSWCLVLQDKPRNAGLASALGSSANDDLQKIHSQPMTPLKELVSFTLKVLNDANETTFAHNTAPYTPGEPDDASLARNRMDPLSSIRPDITSASIAFPDFDFAMPAAGSVTPSQSLTAAGQSIPSTSPAKREATSTEPGPGAANAAEAFGDDLNWMQFLPQTSEGPASASTPALTSSPAMQADPVDQFTAPKGQGASHNSLVSSSDETKSQQPNTSDSAWAFSMSSASAPSDAGAVAANASTSNQPVAPSSLLQPHGQMHSQASTPFQGAQDTTPLSFAQHGPTKRKAGETDIFGNLGLLTEDDFSFFDESAFDLEPERASASLQPTVPHRPTSALSHHSSFGADLGLNPPAGSMNVMSGAALQPGATISAATAPGTVSGLDDVTMDDIGPNSLDALFSAIPGLQDVMATSAEPSQALHAAPSSMATSDSTAQAAQSHLNHPGGSDTNLAAVSSAQSFHPAMTSFTPRDASSTTSFGDPASLPGFTPSSLTESSPAFGGNPSHKTPRTPYSPVEEYRDGATIVGLHDVSRPGEKTQSYREHNAADQAPDASRQHPFDAHHSKGEDQLRLADASSAAAAAANAAMESDTTSRKRPAIVPNAFLPLAQPKARKPLQRLTAGARANLGRKYDLLGKFASKPKTTTAITTVNNSSKSTGQRRVSAEASRIGGRTDRTSAPAPVTGQLVSQFGPTRPSPSKTPSRRGQALLKLHRDRHSKAPPGSGLLGNRRSSSQRVLDVPATPRSSDDIAQMPGAVSDDDSDSSTSDDENTGDLPSDAEGAAGVTLSLEEQMMMKGRSSEVVASFLRGDHVLFSSKREVATKKIGAAGAFSKPTIRRSLLSRTAEWLIGNPQFRAMFGSVSSGSGGSEVAVGDKIEVLEAMASALSLSSHPTTGISEPSNAIKDDGTDVALPTLGSLVKRSSSTAGDDHNIAQVLEPAKIAVGCQGSVIEALPSALMLWDKSKLSAVSGQKHIVAKVLLTHASPAWHDEIVSWLDRLRNAFQAHGLGTHSGGASSILAVADPTEPLALSSYLDRLWKDGEAWLDTLRSIASRISADLLNGKHVVVYTLQPPNSAGCKESGYHGLLRLEADLRAMLREQVGVLAEQVLVRVVSPEMVTEGGSLGLGKETGGVRRLVFGVYDQLGRIVRRQPGKVLHGTEGGAVSGVVDFPVWTLAAGEGRTKFELASGVEPALTDSEGLILHVSYWICQAAPVGGGGGGDGEDATQETLIIVSAMDERASSSTIDVLTTPTGEIENCIEKVWLFAIAQASRARVRWRLAISSASNITRREFTAWHRLVEVYLNATQVNDRVMGSVALLSVRTDESESILLEKSDKVRPSADWTSAATTTTARSEKVLLEASQFSQFLQFQAGMPMNWTTPFGSTLQNTEEEEGEEVLPKQSAILLHKPRRAGAGHVLAVDLIQDWLSQEEGNGWEGIVESLHRLRLVSEERHQLPPPWNGIPWPQGSVGMLSACLDRAMVVD
Length2100
PositionKinase
OrganismUstilago hordei (strain Uh4875-4) (Barley covered smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago.
Aromaticity0.05
Grand average of hydropathy-0.356
Instability index50.13
Isoelectric point6.08
Molecular weight221523.24
Publications
PubMed=22623492

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29563
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.66|      19|      21|      25|      44|       2
---------------------------------------------------------------------------
   26-   44 (25.85/14.50)	.AF.APhARHASLANSPSG.HR
   47-   65 (35.64/16.75)	GGL.GP.AQHASPSSSPAF.PR
   75-   94 (22.17/ 6.89)	GTVsAP..RSAAPPNSLSAqHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      19|      21|    1002|    1022|       3
---------------------------------------------------------------------------
 1002- 1022 (29.78/21.26)	GLDDVTMDDIGPNslDALFSA
 1025- 1043 (33.14/17.72)	GLQDVMATSAEPS..QALHAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.09|      18|      23|     861|     882|       4
---------------------------------------------------------------------------
  861-  879 (29.53/16.39)	NAST...SNQPVAPSSLLQpHG
  884-  904 (28.56/15.87)	QASTpfqGAQDTTPLSFAQ.HG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.27|      20|      21|    1149|    1168|       5
---------------------------------------------------------------------------
  127-  146 (29.64/14.22)	SRrnPQPASVS..DHQAGQQ....DA
 1151- 1172 (33.03/16.77)	SR..PGEKTQSYREHNAADQ..apDA
 1173- 1194 (21.60/ 8.14)	SRqhPFDAHHSKGE....DQlrlaDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     366.41|      93|     152|     750|     852|       6
---------------------------------------------------------------------------
  166-  248 (89.61/29.46)	...............................DLGIAQVLAAARKA..R..AR.S.QAADTSSQPENAG....FKRLLGGGplVYTSSANPSSNDTAAHRldaPSRCAIAdlWLFlAITKDTeAP
  750-  852 (157.51/71.21)	PAKREATSTEPgpgaanaaeaFG.......DDLNWMQFLPQTSEG..P..ASAS.TPALTSSPAMQADPVDQFTAPKGQG..ASHNSLVSSSDETKSQQ...PNTSDSA..WAF.SMSSAS.AP
  905-  997 (119.30/43.80)	PTKRKAGETDI..........FGnlgllteDDFS...FFDESAFDlePerASASlQPTVPHRPTSALSHHSSFGADLGLN..PPAGSMNVMSG..AALQ...PGAT..........ISAAT.AP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.94|      26|      41|    1529|    1554|       7
---------------------------------------------------------------------------
 1529- 1554 (44.42/25.66)	ALPTLGSLVKRS..SSTAGDDHNIAQVL
 1570- 1597 (40.52/22.69)	ALPSALMLWDKSklSAVSGQKHIVAKVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.02|      39|      44|     623|     665|       8
---------------------------------------------------------------------------
  624-  662 (68.19/38.51)	SWCL.VLQDKPRN..AGLASALGSSANDD..LQKIHSQPMTPLK
  666-  709 (53.83/19.87)	SFTLkVLNDANETtfAHNTAPYTPGEPDDasLARNRMDPLSSIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.01|      31|      48|     451|     497|       9
---------------------------------------------------------------------------
  465-  497 (52.12/47.02)	AATPLASTRHAQGSKSD.....RPGPTRArlLLAPLG.C
  511-  547 (44.90/14.75)	ADEQLADLRSMFASVDDdlashRPGDTDS..LASGLAvC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.10|      12|      47|    1605|    1617|      10
---------------------------------------------------------------------------
 1605- 1617 (21.66/16.28)	WHDEiVSWLDRLR
 1655- 1666 (25.44/14.39)	WKDG.EAWLDTLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     465.15|     153|    1026|     257|     427|      12
---------------------------------------------------------------------------
  257-  427 (220.66/110.45)	DATSSTRAQSGDITT...PKAESSAKDGVKRGSsthlvSILDPTVARHlssdvAKAMARLALLADTSTGSYPLASATSTP..VDRKGKEPSLTSEQRAAHKrfmTSLKARAID..SIVNQSAALPVKPQEPGMteMVGTQPQIKRRRLRlGDRIVFlPLCRDDLIKSTTAdASFFSTP
 1293- 1452 (244.49/92.83)	DRTSAPAPVTGQLVSqfgPTRPSPSKTPSRRGQ.....ALLKLHRDRH.....SKAPPGSGLLGNRRSSSQRVLDVPATPrsSDDIAQMPGAVSDDDSDSS...TSDDENTGDlpSDAEGAAGVTLSLEEQMM..MKGRSSEVVASFLR.GDHVLF.SSKREVATKKIGA.AGAFSKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.32|      32|      41|     548|     579|      13
---------------------------------------------------------------------------
  548-  579 (61.41/44.93)	TFPPTQPQRLIPQTHLQ..PNEQPREPFTPNGPV
  590-  623 (52.91/37.35)	TVEHHEQQGLQQQQQQQrsSQEQSQEARQFLWPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.83|      32|     147|    1472|    1504|      14
---------------------------------------------------------------------------
 1472- 1504 (50.18/28.52)	FRAMFGSVSSGSGGSEVAVGDKIEVLeAMASAL
 1620- 1651 (56.66/28.82)	FQAHGLGTHSGGASSILAVADPTEPL.ALSSYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.75|       9|      24|    1231|    1240|      15
---------------------------------------------------------------------------
 1231- 1240 (11.89/ 9.95)	ARKPlQRLTA
 1257- 1265 (15.86/ 7.97)	ASKP.KTTTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      15|      66|    1044|    1060|      16
---------------------------------------------------------------------------
 1044- 1058 (24.61/16.04)	PSSMATSDSTAQAAQ
 1064- 1078 (24.59/ 8.17)	PGGSDTNLAAVSSAQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29563 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAGSVTPSQSLTAAGQSIPSTSPAKREATSTEPGPGAANAAEAFGDDLNWMQFLPQTSEGPASASTPALTSSPAMQADPVDQFTAPKGQGASHNSLVSSSDETKSQQPNTSDSAWAFSMSSASAPSDAGAVAANASTSNQPVAPSSLLQPHGQMHSQASTPFQGAQDTTPLSFAQHGPTKRKAGETDIFG
2) EPERASASLQPTVPHRPTSALSHHSSFGADLGLNPP
3) GSMNVMSGAALQPGATISAATAPGTVSGLDDVTM
4) KYDLLGKFASKPKTTTAITTVNNSSKSTGQRRVSAEASRIGGRTDRTSAPAPVTGQLVSQFGPTRPSPSKTPSRRGQALLKLHRDRHSKAPPGSGLLGNRRSSSQRVLDVPATPRSSDDIAQMPGAVSDDDSDSSTSDDENTGDLPSDAEGAAGVTLSLEEQMM
5) MATSAEPSQALHAAPSSMATSDSTAQAAQSHLNHPGGSDTNLAAVSSAQSFHPAMTSFTPRDASSTTSFGDPASLPGFTPSSLTESSPAFGGNPSHKTPRTPYSPVEEYRDGATIVGLHDVSRPGEKTQSYREHNAADQAPDASRQHPFDAHHSKGEDQLRLADASSAAAAAANAAMESDTTSRKRPAIVPNAFLPLAQPKARKPLQRLTAGARA
6) MSNQASTSTAHGGGAGHSNMAHTPGAFAPHARHASLANSPSGHRRIGGLGPAQHASPSSSPAFPRPFANVASFPGTVSAPRSAAPPNSLSAQHRSIQHLPSLT
7) PTQPQRLIPQTHLQPNEQPREPFTPNGPVDMNMDLDALPTVEHHEQQGLQQQQQQQRSSQEQSQ
8) SKATNAIADATSSTRAQSGDITTPKAESSAKDGVKRGSS
9) TTFAHNTAPYTPGEPDDASLARNRMDPLSS
728
938
975
1249
1030
1
551
249
678
917
973
1008
1412
1244
103
614
287
707










Molecular Recognition Features






MoRF SequenceStartStop




1) ANLGRKYDLLGKFA
2) RRGQALLKLHRDRHSKA
1244
1322
1257
1338