Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MPSATSAGASTSKSESTTSALVLSTLSAYSDLTKQLFSAIENPSSLQKARTISEPHSDKTWRVTNITSILTALSEVDQLFSSRIELARQHALNQARIERLEAQAKKRDRETRQAILELSKIHSELSEISRMSQEEVAWMERAEKRPIGHSTLLAYAQRLAKYTSAPPGYKLPQVAAARSEGVGKREEEEGEGGEEKAISLGADYNQYAKRAAAYYDPAIPSMPQEMPFPSDAMMRQGILNSSEMLEGAPMAEQPAAGEVEMVEDQSEAMLGADFATSYSHLREEQREEVDDEDAFDLDLN |
Length | 300 |
Position | Middle |
Organism | Ustilago hordei (strain Uh4875-4) (Barley covered smut fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.612 |
Instability index | 63.89 |
Isoelectric point | 4.80 |
Molecular weight | 33094.40 |
Publications | PubMed=22623492 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29561 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.48| 14| 42| 24| 38| 1 --------------------------------------------------------------------------- 24- 38 (20.46/17.43) STLSAYSDLtKQLFS 68- 81 (24.02/15.19) SILTALSEV.DQLFS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 146.07| 46| 120| 108| 157| 2 --------------------------------------------------------------------------- 108- 157 (72.60/47.31) DRETRQAILElskiHSELSEISRMSQE....EVAWMERAEKRPIGHSTLLAYAQ 231- 280 (73.48/40.30) DAMMRQGILN....SSEMLEGAPMAEQpaagEVEMVEDQSEAMLGADFATSYSH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AYYDPAIP 2) DAFDLDL 3) SYSHLREEQR | 213 293 277 | 220 299 286 |
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