<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29560

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPSTPHGANGISYNHHVTQSSQPNPSSRSATANNTNMSSNANVMHPSSPSAALSAQQSLGKDKHLLTSPHKLNIGVPPATTPKTHQSLNASTNGQQGHQHQPPHHNGAANGTLTADAKGKQRQVDPIQNIPLVQLEQELPLEETDLVSLAALVERLANYGYESLQNLAETLPSLPSSSKRAKIFNTALDVRKQFIKLLVLSRWSKDVTDLQKARNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLQTGTYRRLPSSIKDMAVAPKPFTDKQALAIVARLEDALRTRMACREYIPAPLSDYSIRDGQVHFRVQGLFEAALTASSGGRDEEADSHVQSAMSGADEAATIGDASVEDRWWLLDLSFDVTPTGSCAASSSRMFPKKPKKAYRERLRIWGDQELAPRPQVQSSDEAKTEQTDVAPQQADLAEEPKGAEEDQDKVQNSDPTVASTEAAQDGQTDRKESKERDASLLRLFAFLQERSLHYQMDILQHQAYALCRLNWGSNLRIETGERPRRLTVHYWTQAQGATGAAQKVDSPAAGGSVQITIVDLPDHAGAAKTLATLFDDDEHQTDQARPVKPTTVKRRGLQVTWDAHSSILADSTTSDLSISPHSLDIEALLSLVIKRHTAALLRNLQRRILVSDHPLSRLLRPEDCTLCVEDAQRQGDEFSTATEMTETSFLQIELRGSDRQRAGRAKQGSMSAMPPLRLSVDPVTGRILLDSEPARVSTDIAVRAGPQQSASFTASILSTRPTFARLAEASDRINGSIDALFDVLYKLEVFARVEEWERMASYLGLRTVRKLNLRPQDLTKFGPSTSPETAPKLFIPLRNSFPGYFLALQPSELAGASIGLVYVVQMMDATGAPSLTVQSIEWLDRTKIASTSKAERGFKNNDLAIAAEIGQKRKATGVQDGTMTDVASSIGTKDLTMEELADVHSYCIALVSYFRVEQQLRMRGIPYLHVGSNTARSAPPAKRQRRIAAPAGAGAQADVRDNGLFEDDEDPSGGTAPGDDGGADASPTHDGHDASEQATADSRVGTLVPTLCLRATDLLGSAKAHLTKPNISLRVRKWDDTDACCVQVLVKLRMKSGRFRQLHEVVAYATTSDQHSTSPATWIDFDDETALLTLSTRDLDNCIPIFYTQWERIMRMVQLTREVLNASRAWQLRALRSRISCKKPSEIVELRRFDFDVVLFSYGTIKVDDLERKLLAHVRWQDAKMEMAPYTNTPMAQSGGYILEFGSIPTSEIDALDKVRDDADAPSAAGATTTAVQREDAVSQWFHDAHASANPHYTMAFELRRTVNIAARSAAMSAMVQPQLERLVWKGFFKLLQDTLPLVREIAPLTQKCLSDPEVPEVEIKDATWFRLRFQDRYALDLRLATRSRLVASDASRPLFRSESQDASKGLNAAERTEQSKDGLFSGSDLLNNLVAGKPGTTDTNVTRPKAKKRTDLSAAMQFQPIPNMDSVLRKIHTWLRTSEDGEAGQQRVWDLRRALLISLAPLDYDKPDGLVGKILPKLVEMVRAEIGAASGE
Length1539
PositionTail
OrganismUstilago hordei (strain Uh4875-4) (Barley covered smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago.
Aromaticity0.06
Grand average of hydropathy-0.441
Instability index49.76
Isoelectric point6.34
Molecular weight169456.00
Publications
PubMed=22623492

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1313.63|     292|     320|     339|     632|       1
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   14-  311 (328.11/162.12)	.....NHHVtQSSQpNPSSRSATAN..NTNMSSNANVMHP.S...SPSAALSAQQS.LGKDKHLLTSPHKL..NIGVPPAT.TPKTH.QSlnaSTNGQQGHQHQP....PhhngaANGT......LTADAK..GKQ..RQVDPIQNI.PLV.........QLEQELPLE..ETD................LVSL.AALVERLAN.....YGYESLQNLAETL...PSL.PS...SSKrakifntaLDVRK.....QFIKLL..VLSRWskdvTDLQKARNiiallSEQQWQHEDVfAGLTDIRKI.LPNA.RMRNADLPTAI..DVLQTGTYRRL.PSSIKDMAVapKPFTDKQAlAIVArleDALRTRMACREY...IPAPLS
  339-  632 (474.19/242.20)	RDEEADSHV.QSAM.SGADEAATIG..DASVEDRWWLLDL.SFDVTPTGSCAASSSRMFPKKPKKAYRERL..RIWGDQEL.APRPQVQS...SDEAKTEQTDVA....P.....QQAD......LAEEPK..GAE..EDQDKVQNSDPTVASTEAAQDGQTDRKESKE.RDAS................LLRLFAFLQERSLH.....YQMDILQHQAYAL...CRL.NW...GSN........LRIET....GERPRRL..TVHYW....TQAQGATG.....AAQKVDSPAA.GGSVQITIVDLPDH.AGAAKTLATLFddDEHQTDQARPVKPTTVKRRGL..QVTWDAHS.SILA...DSTTSDLSISPHSLDIEALLS
  662-  912 (279.30/136.90)	RPEDCTLCV.EDAQ.RQGDEFSTAT..EMT.ETSFLQIELrGSDRQRAGRAKQGSMSAMP..PLRLSVDPVtgRILLDSE.....PARVS...........TDIAvragP.....QQSAsftasiLSTRPT..FARlaEASDRINGS................................................................IDALFDVLYKLevfARVeEWermASY........LGLRTvrklNLRPQDL..T.KFG....PSTSPET.......APKLFIPLR.NSFPGYFLALQPSElAGASIGLVYVV.....QMMDATGAPSLTVQ......SIEWLDRT.KI.A...STSKAERGFKNNDLAIAAEIG
  914- 1138 (232.03/112.05)	KRKA..TGV.QDG..TMTDVASSIGtkDLTMEE...LADV.H......SYCIALVS.YFR......VEQQL..RMRGIPYLhVGSNTARS...APPAKRQRRIAA....P.....AGAG......AQADVRdnGLF..EDDE.....DPS.GGTAPGDDGGADASPTHDgHDASeqatadsrvgtlvptlCLRATDLLGSAKAHltkpnISLRVRKWDDTDA...CCV.QV...LVK........LRMKS....G.RFRQLheVVAY..........ATT.....SDQHSTSPA........TWIDFDDE.T.ALLTLST................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.80|      68|     162|    1272|    1344|       3
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 1272- 1344 (104.21/86.73)	GATTTAVQREDAVSQWFHDAHASANPHYTMAFELRRtVNIAARSAAMSAMVQpqlERlVWKGFFKLLQDTLPL
 1442- 1509 (117.59/79.41)	GTTDTNVTRPKAKKRTDLSAAMQFQPIPNMDSVLRK.IHTWLRTSEDGEAGQ...QR.VWDLRRALLISLAPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29560 with Med14 domain of Kingdom Fungi
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