Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDGRFERLEKALANLIDSVTKFHPSIHQGDELDAADKELTKGLEEVQTHQNNYLRIQQLRESSAALDTQIRETLSNLATTRKDIVTTHTTTFPAGPTYAIAYEELLNYARRISKTTMPPAGTIKAVPATVAPPTPEGQTPGVQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSAMSANTSLPSEWTQFLNPLTDQIFLPWPNDLQLGAGALAAHQVLLEQGINPKGYDPAEEEERKRLEEEERKKKEEEDRIAQEEREKKLREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 343 |
Position | Middle |
Organism | Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.962 |
Instability index | 55.74 |
Isoelectric point | 4.82 |
Molecular weight | 38295.75 |
Publications | PubMed=17823352 PubMed=20237561 PubMed=26198851 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29557 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.97| 14| 15| 256| 269| 1 --------------------------------------------------------------------------- 256- 269 (24.21/13.66) EEEERKKKEEED..RI 272- 287 (17.77/ 8.32) EEREKKLREERErqRI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 99.08| 27| 27| 120| 146| 2 --------------------------------------------------------------------------- 120- 146 (50.03/22.19) TMPPAGTIKAVPATVAPPTPEGQTPGV 148- 174 (49.05/21.64) TPGPDSQTASVMTPSAPPSSQVQSPAV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 83.09| 27| 28| 30| 56| 3 --------------------------------------------------------------------------- 30- 56 (45.03/28.42) IHQGDELDAA.DKELTKGLEEVQTHQNN 60- 87 (38.06/23.00) IQQLRESSAAlDTQIRETLSNLATTRKD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PPQQKAQFQFTNLDDLDDD 2) QEAWRRASLVGGPAA | 321 297 | 339 311 |
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