<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29556

Description Uncharacterized protein
SequenceMTSRTPMGAHPRPPQRSVSSSSLPVQRPPPQRTLSHQQQFVPASPVRKDSSFIDLTADAGDVTPNRYNTTPRRGGSRLRLELSHNASTGPLPTSESPQSLTPSRIPADPFQTMVGSPVPINSANSTSMPMPTRRPVASQLRSAPPITTTTAPALAKKDTRPKPYTVEVPSAAPRYFAANRPETTPRNPVDPFSKGLNSGYADFFPWNGAHYEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPVISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVTGFSEKDWKNRVTYAIRLATNLYSEQLLDRDHYLDWIVSGIENSLQSRIPMWLLIAQIYWKDLLRFRKYGRRLVFALLSHLHVIYNDPDQDLLVQLSSRLSTLLSSLVLSNPESFINPGAWPRYKNTLQAFLRTDHEPTQKSLHIINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESGDDHLAATCWATSENKPLIMKTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDSISIEDKTRKNLIYHLVTELIRTGHFSVSQYMQWTIARGGYHSGAEIDADSGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSIVEEEQDIANAIKFVRHTVGLPLPPGDPLSERKPVSLKRLLPRISSSSGALRSSIGAHLRDVLTSQFNHNSQPSLPLTMYNSIRAIMETAEDYSMLSDILGACSKTADYDVLASVADTVHSNLQIFSALGSANELFNVLIERLKSMNEEQGIVPRPLLASLSSLAQRMAGHEVVASHLRQELLLSDRSNAVDACSPVSDIVAAPTQHAENELAEDIEKQLYSGTRLDPPTMNKLFRRIIPALERGWEKMDDTRRVFATLLTRIRVFDAHHFDKLMTDWTSHVRSLPNRSALVSLFPLLVSTGCLTMPILMSTASPPSTSFQNLSSDPSGNKFGPATYLQELLQLTIMPLPSGTGLFAEENYRFHTEQKCAKFEQSKGLLNLVRNALLEYSGLRNHANSPEFPLDNPACQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPNANEGDQGSSRFEIFAKAMDRAIEAGNIMWTSLLPCLSDDITQHLKSQAQSVFLELIPSSKAPECADTGSRQSLRMAENLLEVVEAIISGQPPPKMAQLSLGMVEKLTDLWEIVAAGPHERPNCYTAVLQHWLPAMLRFVTLHSLSSEPPSAPLPTASATRPPIPPVHDTRARIILVLCGLLLELDTTSPAIAGSLPQQVFDIAILLVDALPEDLRANCAKAILLTSGGLPSQGTSSDPRLYYLFSSPPPSLSDNLMLSHREKAANPQSAVARGMGAQYGIGPAVQERLTPFVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1529
PositionKinase
OrganismGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.233
Instability index51.27
Isoelectric point8.85
Molecular weight168640.86
Publications
PubMed=17823352
PubMed=20237561
PubMed=26198851

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29556
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.12|      39|      97|    1317|    1355|       1
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 1317- 1355 (73.28/37.88)	IVAAGPHE.RPNCYTAVL..QHWLPAM.....LRFVTLHSLSSEPPS
 1411- 1455 (50.25/23.77)	LVDALPEDlRANCAKAILltSGGLPSQgtssdPRLYYL..FSSPPPS
 1474- 1509 (55.59/27.04)	AVARGMGA.QYGIGPAVQ..ERLTPFV.....LR..RWEVLSEPTP.
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.59|      49|      97|     806|     856|       2
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  806-  856 (73.37/51.29)	SMLSDILGACSKTADYDVLASVADTVHSNLQIfsALGSANELFNVLIERLK
  907-  955 (82.22/51.34)	SPVSDIVAAPTQHAENELAEDIEKQLYSGTRL..DPPTMNKLFRRIIPALE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.42|      86|      93|       2|      92|       3
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   13-  103 (144.37/81.66)	P..PQRSVSSSSLPVQRP.......PPQRTLSHQQQFVPasPVRKDssfIDLTADA...GDVTP.................NRYNTT.....PRRGGSRLRLELSHNASTGPLPTSESPQSLTPS
  106-  186 (50.22/19.77)	PadPFQTMVGSPVPINSAnstsmpmPTRRPVASQLRSAP..PITTT......TAPAlakKDTRPkpytvevpsaapryfaaNRPETT.....PR...............................
  731-  786 (61.83/25.04)	.................................................VGLPLPP...GDPLS.................ERKPVSlkrllPRISSSSGALRSSIGAHLRDVLTSQFNHNSQPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.16|      50|      95|     453|     502|       5
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  453-  502 (80.90/42.45)	GRRLVFALLSHLHVIYNDPDQDLL...VQLSSRLSTLLSSLVLSNPESFINPG
  506-  546 (61.30/30.49)	..RYKNTLQAFLRT.DHEPTQKSL...HIINSR....NSRLVVSSTAS..PPA
  547-  596 (72.96/37.60)	GRS...QLVKLLDAALKESGDDHLaatCWATSENKPLIMKTVVEWATSFHRPG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.60|      33|     103|    1267|    1299|       6
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 1267- 1299 (58.07/42.08)	PECADTGSRQSLRMAENLLEV..VEAIISGQPPPK
 1369- 1403 (52.53/37.20)	PPVHDTRARIILVLCGLLLELdtTSPAIAGSLPQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.19|      13|     103|     888|     903|       7
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  888-  903 (17.73/16.45)	SHLRQellLSDRSNAV
  992- 1004 (22.46/11.57)	SHVRS...LPNRSALV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.45|      41|      95|     296|     338|      10
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  252-  282 (28.79/15.66)	..................LNALS.TIFMGVltqrRHRGQINaPSTFKPPP
  289-  331 (70.43/60.82)	TKREVWLKDL..ANPVisLRRLSRTIPHGI....RGRTLLD.QCLNKNVP
  332-  357 (29.23/16.76)	AERAVWLAKCvgANEI...RGLKR...KGV....NG..............
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.25|      24|     679|     386|     434|      11
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  370-  393 (43.23/61.50)	DWTVF.VEQFVDAVVTGF...SEKDWKN
  418-  445 (36.02/15.38)	DWIVSgIENSLQSRIPMWlliAQIYWKD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29556 with Med12 domain of Kingdom Fungi
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