<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29544

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLAKVLTRLAQSTHNALQDQIAALAKMPVPTTAMNGNSTIPNSDVEDASSENIAKKTSILNFAMKEHRKWVKALVITEWSRKADMVSQLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEEIQWMSDVNTQLSLRLNLEDFDKIPYPFRNYEIDSGRVTFKVSGEFEVDLTIADEDFEKQFWFIDFRFAFRPAASSIPEGLKNYLESHVNDILSKDGLLGCYQFLHELVLTHKLNELKRQANQMSRGSWTGTLKVEPLNRALAIQYWTSRTQPGTPKSWVLVAVTSGKKANGQPDPKLSSHLTAKWYRDNKEVKEVKIAFDTDNLSAETLMKTVIGRHIDFLLGSVHSKLLSFPRFQHRQAAMILRTSQDDPAASSLAMRVGFKDSATLLIEPTTGVFAVKPHSKFTWSPENQLNNGKNPAEDGAACLENVRCAVMEDELSRRGSTTGWSIKRSPLNKDELRSLTNTREWTKTIWLHRAGWETNWFVMVLLSPSGDVWWLVDVNRNASGQALRLASKLPLNKGYPRLDDEFWNNLTLFASGMIAQAVDQRELHKQNIKFKPHGANNWSLPQQVRLPTLEIALSGIFPSMVFDNAEKDNPKTAGATEPGKLGPIVRSASASGISTKQPWANDIVSVRFKGVQPAEARPTGPESAKTGDDKSEVPFTCVSDAIIKVRRPAKFAMLKSHMVGRDVSWNARTGEFCLRMRSSIGQSMLESLKARVKAVDRFVSFFESMDKAKEWIVAESVSLKEVTFSYGPQAPEAGNKAQPSRLWRITLNLSQNDIDLVMGETNPHLPVTNLMQKLVNGTNGIGALMNWLPESLPALEAVKKIRETWRDVEARHQGRFRFMMDSVDEMSIQYSLAGTVPGNHLVHREITFLAHIKHRRGEPWWHIMRKPLNGASTPDDEFSKALKPVWEATGEKWTGLVTGAAGRPHDGTASLLLAIDEAIRPLAGSSFQNNSEVVVLE
Length1019
PositionTail
OrganismGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.08
Grand average of hydropathy-0.361
Instability index35.71
Isoelectric point8.57
Molecular weight114052.83
Publications
PubMed=17823352
PubMed=20237561
PubMed=26198851

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29544
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.25|      36|     140|     142|     184|       1
---------------------------------------------------------------------------
  142-  179 (54.62/35.14)	DLKTALQVLSTGEAAWMPDLSyIEpPPLTREEEIQ.WMS
  289-  322 (51.38/23.49)	ELKRQANQMSRG..SWTGTLK.VE..PLNRALAIQyWTS
  330-  361 (51.25/24.32)	KSWVLVAVTSGKKANGQPD......PKLSSHLTAK.WYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.90|      53|     140|     730|     784|       2
---------------------------------------------------------------------------
  730-  784 (88.63/64.44)	PAKFAMLKSHMVGRDVswNAR.TGEFCLRMRSSIGQSMLESLKARVKA...VDRFVSFF
  875-  931 (85.27/54.58)	PALEAVKKIRETWRDV..EARhQGRFRFMMDSVDEMSIQYSLAGTVPGnhlVHREITFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.58|      38|     129|     240|     279|       4
---------------------------------------------------------------------------
  240-  279 (62.84/50.06)	RFAFRPAASSIPEGLKNYLESHVNDIL....SKdgLLGCYQFLH
  370-  411 (59.73/40.33)	KIAFDTDNLSAETLMKTVIGRHIDFLLgsvhSK..LLSFPRFQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.54|      17|     373|     180|     200|       9
---------------------------------------------------------------------------
  180-  200 (27.75/25.67)	DVNTQLS...LRLNledfDKIP....YP
  555-  578 (21.79/10.55)	DVNRNASgqaLRLA....SKLPlnkgYP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29544 with Med14 domain of Kingdom Fungi
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