<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29530

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEGELGQQTVELGAVVRRAAEESYLSLRELVEKSQDEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLEVLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVTDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSSFILDPLTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVIENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAYSGSKFSPGVGLNSYLPSNLRHVQSTNTFSSSTVTKSSSIKLPSSNSNHELSSLSSPTEHVIADGSKSLQLVPASKINGSINLITMGSDGASRKRSISDLFLNLPSLQGLKPSSPRKRRRISESIESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAHMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVKLNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHAPSPANVAATHLGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQPASNANRVNVTQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIEICLENHSGSVSDDVTESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1740
PositionTail
OrganismOryza glaberrima (African rice)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index50.75
Isoelectric point7.99
Molecular weight190308.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.76|      21|      23|     814|     835|       1
---------------------------------------------------------------------------
  514-  532 (27.80/10.37)	RTRSILHLFAATGSFFGLK..
  814-  834 (36.25/16.80)	RKRSISDLFLNLPSLQGLKPS
  838-  855 (29.71/12.99)	KRRRISE...SIESWSPLQAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     139.34|      62|     818|     718|     784|       2
---------------------------------------------------------------------------
  718-  756 (53.76/27.35)	...............................ASSAYSGSKFSPGV.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLNSYLPSNLRHVQSTNTFSSSTVT
  761-  784 (14.42/10.51)	IKlPSSNSNH....ELSSLSSPTEHVIA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1304- 1328 (24.77/ 7.40)	.............................................dgskslqlvpaskingsinlitmgsdgasrkrsisdlflnlpslqglkpssprkrrrisesieswsplqayssdsqsrtsltygnilaernncvpattyasvllhvirhcslsikhaqitahmdslaipyveevglrspssnlwlrlpfarddswkhiclrlgkagsmswdvrindphfrelwelstgstttswgvgvrvantsemdshisfdaegviltysnvepdsvqklvsdlrrlanarsfargmrrligvklndkldddqtstdiksqpvnkgnsdaadrlseqmrktfrieavglmslwfsygtmpmvhfvvewesakggctmhvspdqlwphtkfledfvnggevasfldcirltagpllalggairparmpvtvssgynsmpkqmnniptqgplangsssttmhhapspanvaathlgshnlhtaamlsaagrggpglvpssllpfdvsvvlrgpywiriiyrkkfsvdmrcfagdqvwlqpatppkggplvggslpcpqfrpfimehvaqGLNALEPSFMNATQAGAHLNSSAGT
 1329- 1376 (46.39/19.80)	LQ.PASNANRvnvtQGIGMSRPASGVANhvaANLSRAGNAMLASS.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLAS.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.16|      21|     628|     482|     504|       3
---------------------------------------------------------------------------
  482-  504 (30.91/25.02)	SPENILPPSALLdcEEALNKGSI
 1116- 1136 (40.25/24.49)	SPDQLWPHTKFL..EDFVNGGEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.14|      36|     628|     625|     670|       4
---------------------------------------------------------------------------
  625-  670 (44.68/53.05)	DAKLHAlqniGncDDV.IENRLPIQSGiePL..PLLPaCsPSFSSVVDE
 1261- 1299 (63.46/36.77)	DMRCFA....G..DQVwLQPATPPKGG..PLvgGSLP.C.PQFRPFIME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.67|      32|     135|     944|     975|       5
---------------------------------------------------------------------------
  944-  975 (59.56/37.76)	LRLGKAGSMS.W..DVRINDPHFRELWELSTGSTT
 1078- 1112 (52.12/32.09)	FRIEAVGLMSlWfsYGTMPMVHFVVEWESAKGGCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.00|      49|     105|     206|     254|       6
---------------------------------------------------------------------------
  206-  254 (81.09/56.77)	LLTLGYRGHLDL..WRI..LHLEVLVGDKGGPIKLEER.RRFALGDDIERR..MAV
  257-  297 (45.19/27.89)	......NPFMVL..YAI..LHELCISLAMDTIIRQTNVlRQGRWKDAIRSE.....
  312-  363 (59.72/39.58)	LMQLGQDGEYDLsgSRIpgLKINYWLDEKAGGSAESDS.SPFI...KIEARqdMQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.03|      13|     400|     979|     994|       7
---------------------------------------------------------------------------
  979-  992 (18.63/21.88)	GVGVRVANTsEMDS
 1000- 1012 (23.40/11.10)	GVILTYSNV.EPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.42|      27|     139|     533|     559|      12
---------------------------------------------------------------------------
  533-  559 (48.01/32.78)	VYEKSQGTLKIPKDILHGSDLMVMGFP
  671-  697 (48.41/33.12)	VFEYEHGALAVPNHSLPQTTLQSTSHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29530 with Med14 domain of Kingdom Viridiplantae
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