<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29520

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEVLHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLEISLPKEISEVSVTDGIANVQVDGEFKVLITLGYRGHFSLWRILHMELLVGEKAGPIKLEEIRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNVLRQGRWKDAIKSELISDIGTGQGGSNAVMQLGQDGELDSSGSRIPGLKINYWLEEKNNASAESDSSPYIKIEAGQDMQIKCQHSSFVLDPFTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELMKNVQMSQSPTEVILKREVHGEGFQKRVHRRDSNDCCTNEMLQVRAYGQSYIDLGINIRNGRFLLQSLGNILPPSAVLDSEEALNKGSTTATDVFVSLRTRSILHLFAATGSSLGLKFQVYSQSQVTLKIPKSILCGSEFMVMGFPQCANAYYLLMQLDKSFKPVFCLLEIQSNEGDNNNADATTDAKEAIRFIRIDINKLKIDEDVQIGNFFDKDKLLALQNVEDRPQRQSGADEPLPARPSFFSVVDEVFRCDRGSPITESQRLPPNSLPSSHSSYQVGLHGFSGGAGSPDQDYGSLQSNINAAKVTSGTGLNNYLLSNSKNAQSTSAFSGSVPAGLGNVSSSRSEGAYKKRSLSEFLQNIPSSKQSIIGDGPGKRRKLSEFMLDGLPLKANSPNMQPGTSLTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSLNIPHVEEVGMPTSSSNLWLRLPFAHDASWKHICLHLGKAGSMSWDVRINDPHYGALWKLHGGSTTTEWGSGVRVANTSEVDSHISFDDDGVLLTYNTVEADSIQRLVSDLQRLSHARAFSCGMRRLIGVKLDGKLAEHQTAAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSGCTMRVSPDQLWPHTKFLEDFVNGDEIASFLDCIRLTAGPLLALGGAIRPAKMPVTVPAGYSALPKQNNILTTAGSANSLSSSTVHNMSVPQGAAVAHSNSQLQTSSMLSVAGRTAPGLVPSSLLPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNLLNARHTGPPLNASANTVSGNQQLASAPNRFGGAPGVARSTSTVANQVASSLSRAGNAMMPSGFASGIAGAPAHLSPGNVPAHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRVQLLLQVLNVKRFHHQQQQQQQTPQNNGQEELTVPEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFIKLIAWKKSLPQAHADNATTHRARIEICLEKHPRLVSDDYTASSSSSKSNIHHDRANNSVDFALTFVLDQALVPHMSISGGAAWLPYCVSVRVRYTFGEDSHIAFLAMDGSHSGRACWLQHEDWERCKQRVSRAVETMNGSAAVGDMSQGRLRMVAEMVQKQLQLSLLQLRDSPVSTGSAAS
Length1686
PositionTail
OrganismOryza glaberrima (African rice)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index50.09
Isoelectric point7.73
Molecular weight185168.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29520
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.40|      30|     358|    1198|    1237|       1
---------------------------------------------------------------------------
 1198- 1230 (51.57/50.75)	RN.KFSVDMRCFAGDQvwlQPATPPK...GGPSVGGS
 1261- 1294 (41.82/17.66)	TGpPLNASANTVSGNQ...QLASAPNrfgGAPGVARS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.85|      97|     357|     113|     215|       2
---------------------------------------------------------------------------
  113-  215 (142.14/125.11)	LQQARAPIFDvPSAI....EVLHTGSYRRVPKCVeEIGTQNT..LFQDEQKPTLKKLSTLVRAKlLEISLPKEI...SEVSVTdGIAnvQVDGEFKVLITL..GYRGHFSLWRI
  473-  580 (143.72/101.46)	LLQSLGNILP.PSAVldseEALNKGSTTATDVFV.SLRTRSIlhLFAATGSSLGLKFQVYSQSQ.VTLKIPKSIlcgSEFMVM.GFP..QCANAYYLLMQLdkSFKPVFCLLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.18|      22|      22|     748|     769|       3
---------------------------------------------------------------------------
  723-  741 (30.22/18.33)	LNNYLLSN....SKNA...QSTSAFS
  748-  769 (38.12/25.34)	LGNVSSSR....SEGAYKKRSLSEFL
  771-  794 (25.84/14.44)	..NIPSSKqsiiGDGPGKRRKLSEFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.44|      58|      59|    1432|    1489|       5
---------------------------------------------------------------------------
 1432- 1489 (99.69/72.50)	LL.LQVLNVKRFHHQQQQQQQTPQNNGQEELTVPEISEICDYFSRRVASEPYDASRVAS
 1493- 1551 (92.75/66.88)	LLtLPISVLREFIKLIAWKKSLPQAHADNATTHRARIEICLEKHPRLVSDDYTASSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.38|      10|      22|    1365|    1374|      11
---------------------------------------------------------------------------
 1365- 1374 (16.31/10.19)	LKKVLRGILK
 1389- 1398 (16.07/ 9.93)	LKEILGSVLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.90|      13|     668|     892|     932|      13
---------------------------------------------------------------------------
  876-  888 (27.65/22.99)	W.LRLPFAH.DASWK
  902-  916 (19.25/34.37)	WdVRINDPHyGALWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     238.57|      80|     115|     228|     315|      14
---------------------------------------------------------------------------
  228-  315 (122.12/105.71)	P.IKLEEirryalGDDIE...RRMAVADNPFMILYTILH.EL.CISlVMDTVIRQTNVLRQGRWKDaIKSELISDIGTGQGGSNAVMQLGQDGE
  346-  431 (116.45/79.46)	PyIKIEA......GQDMQikcQHSSFVLDPFTDKEADLSiDLsCID.VEALILKAIACNRHTRLLE.IQRELMKNVQMSQSPTEVILKREVHGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.13|      17|      23|    1296|    1318|      15
---------------------------------------------------------------------------
 1296- 1314 (21.42/23.93)	STVANQVAsSLSrAGN..AMM
 1320- 1338 (28.71/ 9.73)	SGIAGAPA.HLS.PGNvpAHM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29520 with Med14 domain of Kingdom Viridiplantae
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