<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29478

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASELGQQTVELSTLVTRAAHDSYASLKELVDKCKSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQLLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYALTEEQQKPALKKLDTLVRSKLLQVSIPKEFSDIKVSDGTAMLRVDGEFKVLITLGYRGHLSLWRILHLELLVGEKNKPVKLEATRRHLLGDDLERRMAAAENPFSVLYSVLHELCVALVMDTVIRQVQVLRQGRWKDAIRFELISEGHGASSSSAQNPDGESDSSAMRTPGLKIVYWLDFDKNAGASESGTCPFIKIEPGSDLQIKCLHSIFVIDPLTAKDAEFVLDQSCIDVERLLLRAICCNRYTRLLEIKRELVKNVQVCRTTDDVVLQSQMGEPDIEYKQKDEKCHSKDFEGHEVLRVRAYGSSFFTLGINIRNGRFLLQSSQDIVVSSALLECEEALNQGSMTAAEVFISLRSKSILHLFASVGRVLGLEVYEHGFNTVKIPKNVSNGSAMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSGKDNLSGDLNQVLRIKEINIGQMQVQEDEMNLSLVDWGKLRSVLPSAVGPNQTSGDEFFSDVHLENSIQIAKGHPSGFSSLVDEVFGLEKGSSMPPFSVKSLPSSVNTSLPSQYGSVPMNFHSLKAGSPSPKWEVGMQMSQVSNVTKASGATNHYSVKGPLQSSSVGSITTGQGRNSAGKKLSASKSEQDLASLKSPHSVDISSSSAMDEEQLRLLSDTSNDALSGSRSSRLLSPPRPTGSRMSIPNSRPNGLEVESFKAAGSSSCATTPVSQTLESTVSYNTGEDVTSKNDKKSRKRTASDMLTLIPSLQGVESNPGICKRRKISDSSGCQLSLPQGVMSAEMIPKKEGYSYGSLIAEVNKGNVPSSIYIAALLHVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSNNTPWGSGVRIANTSDLDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRAEEKSEELVTSSDTKTSSTKVAPDTADKLTEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGGEVSPLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQTGSYISSQGLLLGNSTTNVGQPTSGPGANTVMPTASGLTSQTLSMLAASGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLANSNNPNPGSGSQMMAANGNRINLPISAAMPRTGNQVASLNRVGNALAGSSNLALMTSAVSLRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGTLLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHSGLNVDENSENSSAFRSNIHYDRLHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESTNVSFIGMNGSHGGRACWLRVDDWEKCKQRVARTVEVNGNSAADVSQGRLKLVADSVQRNLHMCIQGLRDGSGVTASSGAT
Length1806
PositionTail
OrganismGlycine max (Soybean) (Glycine hispida)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.06
Grand average of hydropathy-0.189
Instability index41.97
Isoelectric point7.82
Molecular weight196885.18
Publications
PubMed=20075913

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29478
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1144.74|     333|     352|     802|    1151|       1
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  593-  795 (161.04/88.16)	.............................................................................................................................................................................INIGQM..QVQEDEMNLSLV..DWGKLRS.......VLPSAVGPN.QTSGDEFFSDVHL.ENSIQIA..KGHpsgFSSLVDevfgLEKG....SSMPPFsvkslPSSVNTSLPSQYGS........VPMNFHSLKAGSPSpKW...EVGMQmsQVSNV.TKASGATNHYS..VKGPLQSSSVgsITtgqgrnS....AGKKLSASKSEQDLA.....SLKSPHSVdissssamdeEQLRLLSDT.S
  802- 1151 (538.09/364.61)	SRSSRLLS..PPRPTGSRMSI.PNS.RPNGLEVESFKAAGSSScattPVSQTLESTVSYNTGEDVTSKNDKKSRKRTASDMLTLIPSLQGVE.SNPGIckrrkISDSSGCQLSLP.QGVMSAEMIPKKEGYSYG..SLIAEVNKGN...VPSSiyiaaLL....HVVRHCSLCIKHARL..TSQMDALDISYV..EEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCM.YWDVKIN..DQH...FRDLWE....LQKG....SNNTPW.....GSGVRIANTSDLDSHIHYdPDGVVLSYQSVEVDSIK.KL...VADIQ..RLANARTFALGMRKLLG..VRAEEKSEEL..VT......S....SDTKTSSTKVAPDTAdkLTEQMRRAFRI..........EAVGLMSLW.F
 1156- 1503 (445.61/269.60)	SVLARFVVewESGKEGCTMHVsPDQlWPHTKFLEDFINGGEVS....PLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQTGSYiSSQGL.....LLGNSTTNVGQPtSGPGANTVMPTASGLTSQtlSMLAASGRGGpgiVPSS.....LLpidvSVVLRGPYWI...RImyRKQF.AVDMRCFagDQVWLQPATPPKEGRLS...GGSLP..CPQF.RPFIMeHVAQELNglDPS...FTG.......QQAGglanSNNPNP.....GSGSQMMAAN..GNRINL.PISAAMPRTGNQVASLN.RVgnaLAGSS..NLA.LMTSAVSLRRPPGtvVPAHVRG.EL..NT......AiiglGDDGGYGGGWVPLVA..LKKVLRGILKY..........LGV....LWlF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     376.74|     131|     350|      88|     238|       2
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   88-  238 (184.96/156.62)	HDMCFTQAADSLFFMhEGLqQARAPVYDVPSAIDILLTGSyqrLPKCIEDV..GTQYAltEE.....QQKPALKKLDTLVRSKLLQVsIPKEFSDIK....VSDGTAMLRV...D.G.EFKVLITLGyRGHLSLWRILhlellvgeKNKPvklEATRRHLLGDDLER
  440-  586 (191.78/112.76)	HEVLRVRAYGSSFFT.LGI.NIRNGRFLLQSSQDIVVSSA...LLECEEALnqGSMTA..AEvfislRSKSILHLFASVGRVLGLEV.YEHGFNTVKipknVSNGSAMLLMgfpDcGsSYFLLMQLD.KDFKPLFKLL........ETQP...DPSGKDNLSGDLNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.76|      52|    1364|     252|     311|       3
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  252-  311 (81.96/64.73)	SVLHELCVALVMDTVIRQVQVlrqGRWKDA..IRFELISEGHgasssSAQNPDGES.DSSAMR
 1619- 1673 (81.80/47.72)	SVLREFLKLIAWKKGLSQAQV...GDVVSAqkPRIELCLENH.....SGLNVDENSeNSSAFR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29478 with Med14 domain of Kingdom Viridiplantae
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